1,2-二氯氟乙烷 | 430-57-9

• 物质功能分类: 有机原料 - 有机氟化合物 - 氟乙烷系列
• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 1,2-二氯氟乙烷
• 英文名称: 1,2-dichloro-1-fluoroethane
• 英文别名: 1,2-dichlorofluoroethane；F141；HCFC 141；1,2-dichloro-1-fluoro-ethane；1,2-Dichlor-1-fluor-aethan；1.2-Dichlor-2-fluor-aethan
• CAS: 430-57-9
• 化学式: C₂H₃Cl₂F
• mdl: MFCD00042131
• 分子量: 116.95
• InChiKey: NDKGUMMLYBINOC-UHFFFAOYSA-N

物化性质

• 熔点：
  -60
• 沸点：
  76°C
• 密度：
  1,38 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险等级：
  TOXIC, FLAMMABLE
• 危险品标志：
  F,T
• 安全说明：
  S16,S23,S36/37/39
• 危险类别码：
  R10
• 危险品运输编号：
  UN 1992
• 海关编码：
  2903399090

反应信息

• 作为反应物：
  描述：

  1,2-二氯氟乙烷 在 氯 作用下， 生成 1-氟-1,1,2-三氯乙烷
  参考文献：
  名称：

  The Directing Influence of Substituents on the Chlorination of Halogenated Ethanes and Propanes¹

  摘要：

  DOI：

  10.1021/ja01156a026
• 作为产物：
  描述：

  氟化乙烯 在 氯 作用下， 生成 1,2-二氯氟乙烷
  参考文献：
  名称：

  顺式CHClCHF的ν4吸收带的高分辨率红外激光研究

  摘要：

  摘要 合成了顺式-1-氯-2-氟乙烯，并在1321-1350 cm -1 之间的ν 4 波段区域研究了气相红外光谱，分辨率约为0.002 cm -1 ，采用可调二极管——激光光谱仪。尽管我们的分析指出 a 型分量的强度占主导地位，但对称物质 A ' 的这种振动会产生 a / b 混合带。大多数 J 和 K 结构在不同的子分支中得到解析，并且旋转振动分析导致分配了约 1900 个 a 型谱系，其中 J ≤ 71 和 K a ≤ 20 的 35 个 Cl 同位素物种。ν 4 基波受到弱科里奥利共振的局部扰动，并且发现了一些局部交叉；3ν 12 状态似乎是最可能的相互作用水平。使用 Watson'

  DOI：

  10.1006/jmsp.1999.7948

文献信息

• Reaction of bistrifluoromethylaminosulphenyl chloride with fluoro-olefins and hexafluorobut-2-yne under free-radical conditions
  作者：Colin F. Service、Anthony E. Tipping

  DOI：10.1016/s0022-1139(00)84027-0

  日期：1982.3

  Reaction of bistrifluoromethylaminosulphenyl chloride with unsymmetrical fluoro-olefins in daylight or under photochemical conditions gives both possible 1:1 adducts (ca. 1:1 ratio) arising from homolytic fission of the SCl bond. Addition to octafluorobut-2-ene and hexafluorobut-2-yne gives mixtures of the syn- and anti- adducts.

  在日光下或在光化学条件下，双三氟甲基氨基磺酰氯与不对称氟代烯烃的反应产生了SCl键的均裂裂化产生的两种可能的1：1加合物（比例约为1：1）。除八氟丁-2-烯和六氟丁-2-炔外，可得到正加合物和反加合物的混合物。
• CO₂Laser-induced Decomposition of 1,2-Dichloro-1-fluoroethane
  作者：Hiroo Ogura、Takayuki Yano

  DOI：10.1246/bcsj.58.1239

  日期：1985.4

  IRMPD is direct elimination of molecular HCl and HF, HCl elimination being predominant channel. Primary HCl elimination products cis-and trans-CHF=CHCl, and CH2=CFCl are formed at high vibrational levels, from which additional photon absorption occurs in the secondary photolysis to give rise to CH≡CCl, CH≡CF, and CH2=CHF. All of the secondary products are concluded to be derived from mainly CH2=CFCl

  ClCHFCl 用 TEA CO2 激光在 1033.5 cm-1 处光解。在各种条件下研究了 ClCHFCl 的红外多光子解离机制：样气压力、附加气体压力、脉冲数、脉冲能量和脉冲持续时间。结论是IRMPD的主要过程是分子HCl和HF的直接消除，HCl消除是主要通道。初级 HCl 消除产物顺式和反式 CHF=CHCl 和 CH2=CFCl 在高振动水平下形成，在二次光解中发生额外的光子吸收，产生 CH≡CCl、CH≡CF 和 =CHF . 得出的结论是，所有的副产物主要来源于氯氟乙烯异构体中的 =CFCl。 =CFCl 通过 HF 和 HCl 消除通道以及 C-Cl 键断裂通道分解。CH≡CH似乎是由C2H·自由基的H原子夺取反应生成的，这可能是CH≡CCl和/或CH≡CF的进一步分解所致。更高的整洁 IRMPD...
• Sulfonylureas
  申请人：Ciba-Geigy Corporation

  公开号：US05163996A1

  公开（公告）日：1992-11-17

  N-phenyl-sulfonyl-N'-pyrimidinyl- and -triazinyl-ureas of formula I ##STR1## wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.1 -C.sub.4 haloalkyl, COO--R.sub.2 or A--R.sub.3 ; R.sub.2 is C.sub.1 -C.sub.5 alkyl; R.sub.3 is C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.4 alkoxyalkyl or C.sub.1 -C.sub.5 haloalkyl; X is C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl mono- to tri-substituted by halogen; C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 alkoxy mono- to tri-substituted by halogen; A is oxygen, sulfur, SO or SO.sub.2 ; Y is halogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl mono- to tri-substituted by halogen; C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkoxy mono- to tri-substituted by halogen; cyclopropyl, methylamino or dimethylamino; E is nitrogen or the methine group; and Z is fluorine or chlorine; and the salts of those with amines, alkali or alkaline earth metal bases or with quaternary ammonium bases have good pre- and post-emergence selective herbicidal and growth-regulating properties.

  化学式为I的N-苯基磺酰-N'-嘧啶基和-三嗪基脲，其中R是氢或C.sub.1-C.sub.4烷基；R.sub.1是氢、卤素、C.sub.1-C.sub.5烷基、C.sub.2-C.sub.5烯基、C.sub.1-C.sub.4卤代烷基、COO--R.sub.2或A--R.sub.3；R.sub.2是C.sub.1-C.sub.5烷基；R.sub.3是C.sub.1-C.sub.5烷基、C.sub.2-C.sub.4烷氧基烷基或C.sub.1-C.sub.5卤代烷基；X是C.sub.1-C.sub.3烷基、C.sub.1-C.sub.3烷基单至三个卤素取代基；C.sub.1-C.sub.3烷氧基或C.sub.1-C.sub.3烷氧基单至三个卤素取代基；A是氧、硫、SO或SO.sub.2；Y是卤素、C.sub.1-C.sub.3烷基、C.sub.1-C.sub.3烷基单至三个卤素取代基；C.sub.1-C.sub.3烷氧基、C.sub.1-C.sub.3烷氧基单至三个卤素取代基；环丙基、甲氨基或二甲氨基；E是氮或甲基组；Z是氟或氯；以及与胺、碱或碱土金属基或季铵基的盐具有良好的前期和后期选择性除草和生长调节特性。
• Process for the preparation of 2-(2-halogenoethylthio)-phenylsulfonamides
  申请人：Ciba-Geigy Corporation

  公开号：US05166430A1

  公开（公告）日：1992-11-24

  A 2-(2-halogenoethylthio)-phenylsulfonamide of the formula I ##STR1## in which Z.sub.1 and Z.sub.2 independently of one another are hydrogen, fluorine or chlorine, is prepared by a process wherein: a) a 2-halogenophenylsulfonamide of the formula II ##STR2## in which X is fluorine, chlorine or bromine, is converted, in the presence of a base, together with a mercaptan of the formula III R-SH (III) in which R is C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkyl substituted by phenyl, into a 2-sulfenylphenylsulfonamide, b) this compound is oxidized to give the 2-sulfinylphenylsulfonamide, c) the resulting 2-sulfinylphenylsulfonamide is converted, in the presence of an acid, into the disulfide of the formula VI ##STR3## d) the disulfide of the formula VI is reduced to the 2-mercaptophenylsulfonamide, e) this compound is then converted, by means of a trialkylamine of the formula X (R.sub.1).sub.3 N (X) in which R.sub.1 is C.sub.1 -C.sub.4 alkyl, into the 2-mercaptophenylsulfonamide trialkylamine salt, and f) this compound is then reacted with a halogenofluoroethane of the formula IX Y-CH.sub.2 CFZ.sub.1 Z.sub.2 (IX) in which Y is chlorine or bromine and Z.sub.1 and Z.sub.2 independently of one another are hydrogen, fluorine or chlorine.

  公式I中的2-(2-卤代乙硫基)苯磺酰胺，其中Z1和Z2分别独立地是氢、氟或氯，通过以下步骤制备：a）在碱存在下，将公式II的2-卤代苯磺酰胺转化为2-硫基苯磺酰胺，其中X为氟、氯或溴，b）将该化合物氧化为2-亚磺酰基苯磺酰胺，c）在酸存在下，将所得的2-亚磺酰基苯磺酰胺转化为公式VI的二硫化物，其中R为C1-C6烷基或C1-C6烷基取代的苯基，d）将公式VI的二硫化物还原为2-巯基苯磺酰胺，e）通过公式X（R1）3N（X）的三烷基胺（其中R1为C1-C4烷基），将该化合物转化为2-巯基苯磺酰胺三烷基胺盐，f）然后将该化合物与公式IX的卤代氟乙烷反应，其中Y为氯或溴，Z1和Z2独立地为氢、氟或氯。
• Iodine Excess and Hyperthyroidism
  作者：Elio Roti、Ettore Degli Uberti

  DOI：10.1089/105072501300176453

  日期：2001.5

  150 mug iodine are daily required for thyroid hormone synthesis. The thyroid gland has intrinsic mechanisms that maintain normal thyroid function even in the presence of iodine excess. Large quantities of iodide are present in drugs, antiseptics, contrast media and food preservatives. Iodine induced hyperthyroidism is frequently observed in patients affected by euthyroid iodine deficient goiter when suddenly exposed to excess iodine. Possibly the presence of autonomous thyroid function permits the synthesis and release of excess quantities of thyroid hormones. The presence of thyroid autoimmunity in patients residing in iodine-insufficient areas who develop iodine-induced hyperthyroidism has not been unanimously observed. In iodine-sufficient areas, iodine-induced hyperthyroidism has been reported in euthyroid patients with previous thyroid diseases. Euthyroid patients previously treated with antithyroid drugs for Graves' disease are prone to develop iodine-induced hyperthyroidism. As well, excess iodine in hyperthyroid Graves' disease patients may reduce the effectiveness of the antithyroid drugs. Occasionally iodine-induced hyperthyroidism has been observed in euthyroid patients with a previous episode of post-partum thyroiditis, amiodarone destructive or type II thyrotoxicosis and recombinant interferon-cu induced destructive thyrotoxicosis. Amiodarone administration may induce thyrotoxicosis. Two mechanisms are responsible for this condition. One is related to excess iodine released from the drug, approximately 9 mg of iodine following a daily dose of 300 mg amiodarone. This condition is an iodine-induced thyrotoxicosis or type I amiodarone-induced thyrotoxicosis. The other mechanism is due to the amiodarone molecule that induces a destruction of the thyroid follicles with a release of preformed hormones. This condition is called amiodarone-induced destructive thyrotoxicosis or type II thyrotoxicosis. Patients developing type I thyrotoxicosis in general have preexisting nodular goiter whereas those developing type II thyrotoxicosis have a normal thyroid gland. The latter group of patients, after recovering from the destructive process, may develop permanent hypothyroidism as the consequence of fibrosis of the gland.

表征谱图