托格列净一水合物(1:1) | 1201913-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 中文名称: 托格列净一水合物(1:1)
• 中文别名: 托格列净
• 英文名称: Tofogliflozin hydrate
• 英文别名: (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol;hydrate
• CAS: 1201913-82-7
• 化学式: C22H28O7
• 分子量: 404.5
• InChiKey: ZXOCGDDVNPDRIW-NHFZGCSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.17
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  100
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Diabetes control using postprandial feedback
  申请人：Nath Rattan

  公开号：US10743813B2

  公开（公告）日：2020-08-18

  Disclosed is a postprandial glucose-measuring device for preventing the development of or reversing T2D. Included are methods for using the device as well as better use for invasive and noninvasive glucose meters. Further disclosed are novel exercise-sensitizing compositions useful for managing blood glucose levels in Type-2 diabetics with minimal risk of hypoglycemia. The disclosed glucose meters allow a user to also measure exercise and meal size—all with relatively instant feedback—more effectively than having to track the complexity posed by labels, glycemic index and calories. Also disclosed is integration of glucose-measuring devices with smartphones and health monitoring technology to make possible safe and effective interpretation of postprandial glucose readings by a patient to control or reverse Type-2 diabetes.

  所公开的是一种用于预防或逆转 T2D 的餐后血糖测量装置。还包括使用该装置的方法以及更好地使用有创和无创血糖仪的方法。此外，还公开了新型运动增敏组合物，可用于管理 2 型糖尿病患者的血糖水平，同时将低血糖风险降至最低。所公开的血糖仪还允许用户测量运动量和膳食量--所有这些都有相对即时的反馈--比跟踪标签、血糖生成指数和卡路里带来的复杂性更有效。此外，还披露了葡萄糖测量设备与智能手机和健康监测技术的整合，使患者能够安全有效地解读餐后葡萄糖读数，从而控制或逆转 2 型糖尿病。
• Diabetes Control Using Postprandial Feedback
  申请人：Nath Rattan

  公开号：US20170258395A1

  公开（公告）日：2017-09-14

  Disclosed is a postprandial glucose-measuring device for preventing the development of or reversing T2D. Included are methods for using the device as well as better use for invasive and noninvasive glucose meters. Further disclosed are novel exercise-sensitizing compositions useful for managing blood glucose levels in Type-2 diabetics with minimal risk of hypoglycemia. The disclosed glucose meters allow a user to also measure exercise and meal size—all with relatively instant feedback—more effectively than having to track the complexity posed by labels, glycemic index and calories. Also disclosed is integration of glucose-measuring devices with smartphones and health monitoring technology to make possible safe and effective interpretation of postprandial glucose readings by a patient to control or reverse Type-2 diabetes.