1-(1-萘氧基)-2-羟基-苯 | 1027530-83-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(1-萘氧基)-2-羟基-苯
• 英文名称: 1-(1-naphthyloxy)-2-hydroxy-benzene
• 英文别名: 2-(naphthalen-1-yloxy)phenol；2-Naphthalen-1-yloxyphenol
• CAS: 1027530-83-1
• 化学式: C₁₆H₁₂O₂
• 分子量: 236.27
• InChiKey: ITPBGGQIWAKCCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1-萘氧基)-2-羟基-苯 在 ammonium hydroxide 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 1-(2-(2-(naphthalen-1-yloxy)phenoxy)ethyl)pyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers

  摘要：

  Catechol diethers that incorporate a 6-cyano-1-naphthyl substituent have been explored as non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Promising compounds are reported that show midpicomolar activity against the wild-type virus and sub-20 nM activity against viral variants bearing Tyr181Cys and Lys103Asn mutations in HIV-RT. An X-ray crystal structure at 2.49 angstrom resolution is also reported for the key compound 6e with HIV-RT.

  DOI：

  10.1021/ml5003713
• 作为产物：
  描述：

  2-溴苯甲醚 在 copper(l) iodide 、 三溴化硼 、 N,N-二甲基甘氨酸盐酸盐 、 caesium carbonate 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 48.0h， 生成 1-(1-萘氧基)-2-羟基-苯
  参考文献：
  名称：

  COMPOUNDS AND METHODS FOR TREATING HIV INFECTIONS

  摘要：

  本发明涉及新型纳摩尔和皮摩尔HIV逆转录酶抑制剂，以及由此制备的药物组合物和用于抑制逆转录酶和治疗HIV感染的方法，特别包括对HIV-1和HIV-2的耐药菌株以及作为HIV感染后果发生的次生疾病状态和/或条件。

  公开号：

  US20150105351A1

文献信息

• Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition
  申请人：Acuff Cory

  公开号：US20110274651A1

  公开（公告）日：2011-11-10

  Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of viruses and other microbes within mammalian and other cells by inhibiting the cytoplasmic transport mechanisms within the cells. The compositions described herein include an effective amount of the noscapine analogues described herein, along with a pharmaceutically acceptable carrier or excipient. The compositions can also include one or more additional antimicrobial compounds.

  本发明公开了用于治疗或预防传染病、抑制微生物在哺乳动物细胞内移动和抑制微生物复制能力的组合物和方法。该组合物包括各种诺斯卡平类似物，能够通过抑制细胞内的胞质转运机制，阻止病毒和其他微生物在哺乳动物和其他细胞内移动。本发明所描述的组合物包括所述诺斯卡平类似物的有效量，以及药学上可接受的载体或赋形剂。该组合物还可以包括一个或多个额外的抗微生物化合物。
• EPOXY RESIN COMPOSITION FOR FIBER-REINFORCED COMPOSITE MATERIALS, PREPREG, AND FIBER-REINFORCED COMPOSITE MATERIAL
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20140309337A1

  公开（公告）日：2014-10-16

  Provided are: a fiber-reinforced composite material which is suppressed in morphology variation due to the molding conditions, while having excellent mode I interlaminar fracture toughness and excellent wet heat resistance; an epoxy resin composition for obtaining the fiber-reinforced composite material; and a prepreg which is obtained using the epoxy resin composition. An epoxy resin composition for fiber-reinforced composite materials, which contains at least the following constituent elements [A]-[F], and which is characterized by containing 5-25 parts by mass of constituent element [C] and 2-15 parts by mass of constituent element [E] per 100 parts by mass of the total epoxy resin blended therein. [A] A bifunctional amine type epoxy resin. [B] A tetrafunctional amine type epoxy resin. [C] A bisphenol F type epoxy resin having an epoxy equivalent weight of 450-4,500. [D] An aromatic amine curing agent. [E] A block copolymer having a reactive group that can be reacted with as epoxy resin. [F] Thermoplastic resin particles that are insoluble in an epoxy resin.

  提供了一种纤维增强复合材料，其在成型条件下具有抑制形态变化的特性，同时具有优异的I型层间断裂韧性和出色的耐湿热性能；一种用于制备纤维增强复合材料的环氧树脂组合物；以及使用该环氧树脂组合物制备的预浸料。一种用于纤维增强复合材料的环氧树脂组合物，其中至少包含以下组分[A]-[F]，并且其特征是每100份环氧树脂中含有5-25份组分[C]和2-15份组分[E]。[A] 双官能基胺型环氧树脂。[B] 四官能基胺型环氧树脂。[C] 具有450-4,500环氧当量重的双酚F型环氧树脂。[D] 芳香胺固化剂。[E] 具有可与环氧树脂反应的反应性基团的嵌段共聚物。[F] 在环氧树脂中不溶的热塑性树脂颗粒。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 133, page 368 - 371
  作者：

  DOI：——

  日期：——
• Schwarz, R.; Kuchen, W., Chemische Berichte, 1953, vol. 86, p. 1144 - 1149
  作者：Schwarz, R.、Kuchen, W.

  DOI：——

  日期：——
• NOSCAPINE AND NOSCAPINE ANALOGS AND THEIR USE IN TREATING INFECTIOUS DISEASES BY TUBULIN BINDING INHIBITION
  申请人：Emory University

  公开号：EP2328578A2

  公开（公告）日：2011-06-08