1-氯-2-甲基-1-丙烷-2-氧基丙烷 | 62456-40-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-氯-2-甲基-1-丙烷-2-氧基丙烷
• 英文名称: 1-chloro-2-methylpropyl isopropyl ether
• 英文别名: (1-Chlor-2-methylpropyl)isopropylaether；1-chloro-1-isopropoxy-2-methyl-propane；1-Chloro-2-methyl-1-[(propan-2-yl)oxy]propane；1-chloro-2-methyl-1-propan-2-yloxypropane
• CAS: 62456-40-0
• 化学式: C₇H₁₅ClO
• 分子量: 150.649
• InChiKey: JUZDXTXODVOHCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-氯-2-甲基-1-丙烷-2-氧基丙烷 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 生成 1-tert-butoxy-4-isopropoxy-5-methyl-hexa-1,2-diene
  参考文献：
  名称：

  Mantione,R., Bulletin de la Societe Chimique de France, 1969, p. 4523 - 4527

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁醛 、 异丙醇 在 盐酸 作用下， 生成 1-氯-2-甲基-1-丙烷-2-氧基丙烷
  参考文献：
  名称：

  Schaumann,E.; Grabley,F.-F., Justus Liebigs Annalen der Chemie, 1977, p. 88 - 100

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING COMPOUND HAVING ACID-LABILE GROUP
  申请人：Kyowa Hakko Chemical Co., Ltd.

  公开号：EP1661918A1

  公开（公告）日：2006-05-31

  The present invention provides a process for producing a compound having a group represented by general formula (II): (wherein R1, R2, and R3 may be the same or different, and each represent a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted aralkyl, or R1 and R2 may bind to each other to form an alicyclic hydrocarbon ring together with the adjacent carbon atoms, or R2 and R3 may bind to each other to form a alicyclic heterocyclic ring together with the adjacent O-C-C that may have a substituent), which comprises allowing a compound having a hydroxyl group to react with halogenated alkyl ether represented by general formula (I): (wherein R1, R2, and R3 are the same as those defined above, respectively and X represents a halogen atom).

  本发明提供了一种生产具有由通式（II）表示的基团的化合物的方法：（其中R1、R2和R3可以相同也可以不同，并且分别表示取代或未取代的烷基、取代或未取代的芳基、或取代或未取代的芳基烷基，或者R1和R2可以相互结合形成与相邻碳原子一起的脂环碳氢环，或者R2和R3可以相互结合形成与相邻的O-C-C一起具有取代基的脂环杂环）的方法，该方法包括允许具有羟基的化合物与由通式（I）表示的卤代烷基醚发生反应：（其中R1、R2和R3分别与上述定义相同，X代表卤素原子）。
• Torsional effects on reactivity in glycosyl transfer
  作者：Kathryn E. S. Dean、Anthony J. Kirby、Igor V. Komarov

  DOI：10.1039/b106257n

  日期：2002.1.23

  the parent tetrahydropyranyl acetal. The magnitude of the steric contribution to this factor is assessed by measuring the effect of four equatorial methyl groups on the rate of hydrolysis of 4-nitrophenyl tetrahydropyranyl acetal. Though the electronic effects of methyl substituents will be to increase the rate of hydrolysis, the net effect of the four equatorial methyl groups is a 4-fold decrease,

  与母体四氢吡喃基乙缩醛相比，四个取代基对六吡喃糖苷的净作用是将在异头异构体中心的反应性降低> 10 7倍。通过测量四个赤道甲基对4-硝基苯基四氢吡喃基乙缩醛水解速率的影响，可以评估对该因子的空间贡献的大小。尽管甲基取代基的电子效应将提高水解速率，但四个赤道甲基的净效应却降低了4倍，这证明了相反的空间效应估计在两个数量级。糖吡喃糖苷的扭转作用因此对总共10 7贡献了高达50的因子。
• Method for producing compound having acid-labile group
  申请人：Matsuoka Hiroshi

  公开号：US20060177763A1

  公开（公告）日：2006-08-10

  The present invention provides a process for producing a compound having a group represented by general formula (II). (wherein R 1 , R 2 , and R 3 may be the same or different, and each represent a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted aralkyl, or R 1 and R 2 may bind to each other to form an alicyclic hydrocarbon ring together with the adjacent carbon atoms, or R 2 and R 3 may bind to each other to form a alicyclic heterocyclic ring together with the adjacent O—C—C that may have a substituent), which comprises allowing a compound having a hydroxyl group to react with halogenated alkyl ether represented by general formula (I): (wherein R 1 , R 2 , and R 3 are the same as those defined above, respectively and X represents a halogen atom).
• PROCESS FOR PRODUCING COMPOUND HAVING ACID-LABILE GROUP
  申请人：Matsuoka Hiroshi

  公开号：US20090035702A1

  公开（公告）日：2009-02-05

  The present invention provides a process for producing a compound having a group represented by general formula (II): (wherein R 1 , R 2 , and R 3 may be the same or different, and each represent a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted aralkyl, or R 1 and R 2 may bind to each other to form an alicyclic hydrocarbon ring together with the adjacent carbon atoms, or R 2 and R 3 may bind to each other to form a alicyclic heterocyclic ring together with the adjacent O—C—C that may have a substituent), which comprises allowing a compound having a hydroxyl group to react with halogenated alkyl ether represented by general formula (I): (wherein R 1 , R 2 , and R 3 are the same as those defined above, respectively and X represents a halogen atom).