[EN] VIRAL POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS DE POLYMERASE VIRALE
申请人:BOEHRINGER INGELHEIM INT
公开号:WO2004065367A1
公开(公告)日:2004-08-05
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling
作者:Peter G. N. Neate、Bufan Zhang、Jessica Conforti、William W. Brennessel、Michael L. Neidig
DOI:10.1021/acs.orglett.1c02053
日期:2021.8.6
Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada–Tamao–Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized electrophiles as well as aryl Grignard reagents with sp3-hybridized electrophiles. This represents a rare
heteroaryl, alkyl, or benzylic polyfunctional zinc reagents obtained by the addition of zinc and LiCl to the corresponding organic iodides undergo smooth Pd(0)-catalyzed cross-coupling reactions with aryl bromides, chlorides, and triflates in the presence of PEPPSI as a catalyst. This procedure avoids the manipulation of water and air-sensitive organozincreagents and produces cross-coupling products in high
Stereocontrolled synthesis of bicyclic ureas and sulfamides via Pd-catalyzed alkene carboamination reactions
作者:Nicholas R. Babij、Jordan R. Boothe、Grace M. McKenna、Ryan M. Fornwald、John P. Wolfe
DOI:10.1016/j.tet.2019.04.031
日期:2019.8
The synthesis of bicyclic ureas and sulfamides via palladium-catalyzed alkene carboamination reactions between aryl/alkenylhalides/triflates and alkenes bearing pendant cyclic sulfamides and ureas is described. The substrates for these reactions are generated in 3-5 steps from commercially available materials, and products are obtained in good yield with up to >20:1 diastereoselectivity. The stereochemical
A novel procedure for the synthesis of C2‐diversified oxazoles, through palladium‐catalyzed imidoylative cyclization of α‐isocyanoacetamides with aryl, vinyl, alkynyl halides, or triflates, was developed. Migratory insertion of isocyanide into a C‐palladium(II) intermediate in a cascade process was also realized, generating alkyl‐substituted oxazoles. Therefore, oxazoles functionalized at the C2 position