1-芘丁酸 | 3443-45-6

• 物质功能分类: 化学试剂 - 有机试剂 - 多环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 中文名称: 1-芘丁酸
• 中文别名: 1-吡啶酸；4-(3-芘基)丁酸
• 英文名称: 1-pyrenebutyric acid
• 英文别名: pyrenebutyric acid；4-(pyren-1-yl)butanoic acid；4-(1-pyrenyl)butyric acid；4-pyren-1-ylbutanoic acid
• CAS: 3443-45-6；25338-56-1
• 化学式: C₂₀H₁₆O₂
• mdl: MFCD00004141
• 分子量: 288.346
• InChiKey: QXYRRCOJHNZVDJ-UHFFFAOYSA-N

物化性质

• 熔点：
  184-186 °C (lit.)
• 沸点：
  370.57°C (rough estimate)
• 密度：
  1.1742 (rough estimate)
• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2916399090
• 危险品运输编号：
  UN 3077
• 危险标志：
  GHS07
• 危险性描述：
  H315,H319,H335
• 危险性防范说明：
  P261,P305 + P351 + P338

制备方法与用途

用途：荧光探针。

反应信息

• 作为反应物：
  描述：

  1-芘丁酸 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 4-芘-1-基丁酸钠
  参考文献：
  名称：

  Simultaneous Noncovalent Modification and Exfoliation of 2D Carbon Nitride for Enhanced Electrochemiluminescent Biosensing

  摘要：

  As an emerging nitrogen-rich 2D carbon material, graphitic carbon nitride (CN) has drawn much attention for applications ranging from photo-/electrocatalysts to biosensors. Interfacial modification of CN is fundamentally vital but is still in, its infancy and remains challenging due to the low reactivity of CN. Here we report that, in conjunction with a pi-pi stacking interaction, bulk CN could be simultaneously exfoliated via facile mechanical grinding. The obtained CN nanosheets (m-CNNS) not only retained the pristine optoelectronic properties of bulk CN but also enriched a friendly interface for further coupling biomolecules with advanced properties, overcoming the deficiencies of CN in surface science. The m-CNNS were further covalently linked to a DNA probe, and the resultant electrochemiluminescent biosensor for the target DNA exhibited much enhanced sensitivity with respect to that obtained by direct physical absorption of the DNA probe on unmodified CNNS. This noncovalent exfoliation and interfacial modification should greatly expand the scope of potential applications of CN in areas such as biosensing and should also be applicable to other 2D materials in interface modulation.

  DOI：

  10.1021/jacs.7b06708
• 作为产物：
  描述：

  芘 在 盐酸 、 三氯化铝 、 amalgamated zinc 、 溶剂黄146 、 硝基苯 作用下， 生成 1-芘丁酸
  参考文献：
  名称：

  Flagellar microstructures of male tiger beetles (Coleoptera: Cicindelidae): implications for systematics and functional morphology

  摘要：

  摘要 对北美和亚洲的 10 种虎甲虫雄性内囊鞭毛上的齿状结构（称为 "鬓毛"）进行了比较，结果与早先提出的林内虎甲虫属（Cicindela Linné）一致，这里将其列为亚属。根据扫描电子显微照片观察发现，鞭毛全长有一条沟，沟内有鬓毛，大多数物种的鬓毛只存在于无沟鞭毛表面的一侧；鬓毛在鞭毛表面和鞭毛沟内都指向基部（近端）；鬓毛的分布模式似乎是每个亚属独有的。Cicindela punctulata Olivier 和 Cicindela lepida Dejean 这两个物种有一个管腔，而不是鞭毛沟，前者在无沟槽的鞭毛表面上有鬓毛，后者则没有。鞭毛无凹槽表面上的鬓毛被认为是在授精或授精前的清管过程中，鞭毛穿透精囊管时用来抓紧精囊管内壁的。鞭毛一侧的鬓角能促进鞭毛快速、顺畅地插入精管或从精管中拔出。据推测，鞭毛沟的鬓角可在鞭毛插入精囊管时引导精囊窄颈进入精囊管，从而帮助精液流向精囊。

  DOI：

  10.4039/ent133633-5

文献信息

• SOLID SUPPORTS AND PHOSPHORAMIDITE BUILDING BLOCKS FOR OLIGONUCLEOTIDE CONJUGATES
  申请人：AM Chemicals LLC

  公开号：US20180016232A1

  公开（公告）日：2018-01-18

  Novel non-nucleoside solid supports and phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one non-nucleosidic moiety conjugated to a ligand of practical interest and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said solid supports and phosphoramidite building blocks, preferably followed by removal of protecting groups to provide oligonucleotides conjugated to ligands of interest.

  揭示了用于制备含有至少一个非核苷酸基团与实用兴趣配体共轭的合成寡核苷酸的新型非核苷酸固相支持体和磷酰胺酸酯构建块，以及制备这些固相支持体和磷酰胺酸酯构建块的合成过程。此外，使用所述固相支持体和磷酰胺酸酯构建块制备寡聚合物化合物，最好是在去除保护基的情况下，以提供与感兴趣的配体共轭的寡核苷酸。
• Trigger-responsive chain-shattering polymers
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：US09593197B2

  公开（公告）日：2017-03-14

  Disclosed are polymers containing a backbone comprising alternating N-protected hydroxymethylaniline units (“spacer”) and linker units.

  披露的是含有交替的N-保护羟甲基苯胺单元（“间隔物”）和连接单元的聚合物。
• Compounds for determining the activity of phospholipase A2
  申请人：Sirs-Lab GmbH

  公开号：US07301043B2

  公开（公告）日：2007-11-27

  Compounds for determining the activity of phospholipase A2, are described herein, and include embodiments having formula (1) wherein L1 is derived from an ether (R1—OR2)m, wherein R1 and R2 are independently selected and are derived from a hydrocarbon having 1 to 12 carbon atoms, with m being an integer from 1 to 4, or from a hydrocarbon R having 1 to 20 carbon atoms; F is unsubstituted or substituted pyrene as a flouraphore; Q is a quencher, and L2 is C(O)-L1 or C(O)-L1-NH, wherein L1 is as defined above. These compounds may be used to determine the activity of phospholipase A2, in particular PAF-AH.

  用于确定磷脂酶A2活性的化合物在此处描述，并包括具有以下式（1）的实施例 其中 L1源自醚（R1—OR2）m，其中R1和R2独立选择并源自具有1至12个碳原子的碳氢化合物，m为1至4的整数，或源自具有1至20个碳原子的碳氢化合物R; F是未取代或取代的芘作为荧光素; Q是一个猝灭剂，以及 L2是C(O)-L1或C(O)-L1-NH，其中L1如上定义。这些化合物可用于确定磷脂酶A2的活性，特别是PAF-AH。
• Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XVIII: Oligoamines with Fluorescent Properties, Part B: Fluorophores in the Molecular Periphery
  作者：K. Rehse、T. Seidel

  DOI：10.1002/ardp.19943270611

  日期：——

  Seventeen N,N′‐benzene‐1,3‐dimethane and nine N,N′,N″‐benzene‐1,3,5‐trimethane derivatives with fluorescent properties have been synthesized. Three of them show antiplatelet activities (inducer collagen, IC50 Born‐test) in concentrations < 10 μmol/L. They are suitable for interaction studies with biological macromolecules and synthetical and biological membranes. Structure activity relationships demonstrate

  已经合成了 17 种具有荧光特性的 N, N' - 苯 - 1,3 - 二甲烷和九种 N, N ', N ' - 苯 - 1,3,5 - 三甲烷衍生物。其中三个在 <10 μmol / L 的浓度下显示出抗血小板活性（诱导剂胶原蛋白，IC50 Born 测试）。它们适用于与生物大分子以及合成和生物膜的相互作用研究。构效关系表明杂多环荧光团，即喹啉、二苯并呋喃或咔唑是实现此目的的有利替代品。
• Rational Design for Complementary Donor-Acceptor Recognition Pairs Using Self-Complementary Hydrogen Bonds
  作者：Amrita Sikder、Boyli Ghosh、Saptarshi Chakraborty、Ankan Paul、Suhrit Ghosh

  DOI：10.1002/chem.201504092

  日期：2016.2.5

  An adaptable and efficient molecular recognition pair has been established by taking advantage of the complementary nature of donor–acceptor interactions together with the strength of hydrogen bonds. Such distinct molecular recognition propagates in orthogonal directions to effect extended alternating co‐assembly of two different appended molecular entities. The dimensions of the assembled structures

  通过利用供体-受体相互作用的互补性以及氢键的强度，建立了一种适应性强且高效的分子识别对。这种不同的分子识别在正交方向上传播，以实现两个不同附加分子实体的扩展交替共组装。可以通过供体和受体结构单元之间的化学计量不平衡来调节组装结构的尺寸。自组装材料的形态可以与两个构件的比例相关。

表征谱图