N-[2-(2-hydroxyethoxy)ethyl]-4-pyren-1-ylbutyramide | 1232169-23-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: N-[2-(2-hydroxyethoxy)ethyl]-4-pyren-1-ylbutyramide
• 英文别名: N-[2-(2-hydroxyethoxy)ethyl]-4-pyren-1-ylbutanamide
• CAS: 1232169-23-1
• 化学式: C₂₄H₂₅NO₃
• 分子量: 375.467
• InChiKey: DDXSTZJDRKHBFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-hydroxyhexanoic acid 2-[2-(4-pyren-1-ylbutyrylamino)ethoxy]ethyl ester 在 lipoprotein lipase from Pseudomonas sp. 作用下， 反应 16.0h， 生成 N-[2-(2-hydroxyethoxy)ethyl]-4-pyren-1-ylbutyramide
  参考文献：
  名称：

  Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker

  摘要：

  Several polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays. Pseudomonas lipases were found to most readily cleave the solution-phase analogue and this observation translated well to the corresponding polymeric supports, where the most effective were PEGA resins and the LPOS support PEG-6000. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.040

文献信息

• Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker
  作者：Ana Chiva、David E. Williams、Alethea B. Tabor、Helen C. Hailes

  DOI：10.1016/j.tetlet.2010.03.040

  日期：2010.5

  Several polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays. Pseudomonas lipases were found to most readily cleave the solution-phase analogue and this observation translated well to the corresponding polymeric supports, where the most effective were PEGA resins and the LPOS support PEG-6000. (C) 2010 Elsevier Ltd. All rights reserved.