氨氧基-五聚乙二醇-氨氧基 | 894414-82-5

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 氨氧基-五聚乙二醇-氨氧基
• 英文名称: 3,6,9,12,15-penatoxa-heptadecane-1,17-dioxyamine
• 英文别名: O,O'-(3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl)bis(hydroxylamine)；O-[2-[2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]hydroxylamine
• CAS: 894414-82-5
• 化学式: C₁₂H₂₈N₂O₇
• 分子量: 312.364
• InChiKey: FGWMKAWTYWONHC-UHFFFAOYSA-N

物化性质

• 沸点：
  449.7±45.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  21
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-[2-[2-[2-[2-(2-羟基乙氧基)乙氧基]乙氧基]乙氧基]乙氧基]乙醇,二氯化 在 endo-N-Hydroxy-5-norbornene-2,3-dicarboximide 、 一水合肼 作用下， 以 N,N-二甲基甲酰胺 、 乙醇 为溶剂， 生成 氨氧基-五聚乙二醇-氨氧基
  参考文献：
  名称：

  THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME

  摘要：

  本公开涉及将水溶性聚合物与治疗性蛋白质结合的材料和方法。

  公开号：

  US20180318432A1

文献信息

• BLOOD COAGULATION PROTEIN CONJUGATES
  申请人：BAXALTA INCORPORATED

  公开号：US20160120994A1

  公开（公告）日：2016-05-05

  The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a blood coagulation protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer. In one embodiment of the invention the conjugation is carried out in the presence of the nucleophilic catalyst aniline. In addition the generated oxime linkage can be stabilized by reduction with NaCNBH 3 to form an alkoxyamine linkage.

  本发明涉及将水溶性聚合物与血凝蛋白的氧化碳水化合物部分偶联的材料和方法，包括在允许偶联的条件下，将氧化碳水化合物部分与活性水溶性聚合物接触。更具体地，本发明涉及上述材料和方法，其中水溶性聚合物含有活性氨氧基，并在氧化碳水化合物部分和水溶性聚合物上的活性氨氧基之间形成肟键。在本发明的一种实施方式中，偶联是在亲核催化剂苯胺的存在下进行的。此外，生成的肟键可以通过还原NaCNBH3来形成烷氧胺键。
• MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN
  申请人：Siekmann Juergen

  公开号：US20120190096A1

  公开（公告）日：2012-07-26

  The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water soluble fatty acid derivative under conditions that allow conjugation.

  本发明涉及一种将水溶性脂肪酸衍生物与治疗蛋白质结合的材料和方法，包括将治疗蛋白质与活化的水溶性脂肪酸衍生物接触，在允许结合的条件下进行。
• Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
  申请人：Ambrx, Inc.

  公开号：EP2399893A2

  公开（公告）日：2011-12-28

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oximine, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

  本文公开了非天然氨基酸和包括至少一种非天然氨基酸的多肽，以及制造这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分，可包括多种可能的官能团，但典型的至少有一个肟基、羰基、二羰基和/或羟胺基。本文还公开了经翻译后进一步修饰的非天然氨基酸多肽、进行此类修饰的方法以及纯化此类多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟基、羰基、二羰基和/或羟胺基团。进一步公开的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗、诊断和其它生物技术用途。
• NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
  申请人：Baxalta GmbH

  公开号：EP3505186A1

  公开（公告）日：2019-07-03

  The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.

  本发明涉及将水溶性聚合物与治疗蛋白质的氧化碳水化合物分子共轭的材料和方法，包括在允许共轭的条件下将氧化碳水化合物分子与活化的水溶性聚合物接触。更具体地说，本发明涉及上述材料和方法，其中水溶性聚合物含有活性氨基氧基，氧化的碳水化合物分子与水溶性聚合物上的活性氨基氧基之间形成肟或腙连接，并且在亲核催化剂存在下进行共轭。
• METHODS FOR PREPARING THERAPEUTIC PROTEIN-POLYMER CONJUGATES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP4019049A1

  公开（公告）日：2022-06-29

  The Invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contracting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.

  本发明涉及将水溶性聚合物与治疗性蛋白质的氧化碳水化合物分子共轭的材料和方法，包括在允许共轭的条件下将氧化碳水化合物分子与活化的水溶性聚合物收缩。更具体地说，本发明涉及上述材料和方法，其中水溶性聚合物含有活性氨基氧基，氧化的碳水化合物分子与水溶性聚合物上的活性氨基氧基之间形成肟或腙连接，并且在亲核催化剂存在下进行共轭。