2,4-二羟基-1,3,5-三甲基苯 | 608-98-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2,4-二羟基-1,3,5-三甲基苯
• 英文名称: 2,4-dihydroxy-1,3,5-trimethylbenzene
• 英文别名: 2,4,6-trimethylresorcinol；2,4,6-trimethyl-resorcinol；2,4,6-Trimethyl-resorcin；2.4-Dihydroxy-1.3.5-trimethyl-benzol；2.4-Dihydroxy-mesitylen；Mesorcin；2,4,6-Trimethylbenzene-1,3-diol
• CAS: 608-98-0
• 化学式: C₉H₁₂O₂
• mdl: MFCD00667780
• 分子量: 152.193
• InChiKey: WSKJIXLOKYWORS-UHFFFAOYSA-N

物化性质

• 熔点：
  150.8°C
• 沸点：
  274.5°C (estimate)
• 密度：
  1.0505 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2907299090

反应信息

• 作为反应物：
  描述：

  2,4-二羟基-1,3,5-三甲基苯 、 乙酸酐 生成 3-acetoxy-2,4,6,trimethylphenyl acetate
  参考文献：
  名称：

  Knecht, Justus Liebigs Annalen der Chemie, 1882, vol. 215, p. 83

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-二硝基-2,4,6-三甲基苯 在 ammonium hydroxide 、 硫化氢 作用下， 以 乙醇 为溶剂， 生成 2,4-二羟基-1,3,5-三甲基苯
  参考文献：
  名称：

  THE METHYLATION OF THE RESORCINOLATE DIANION: I. THE EFFECTS OF SOLVENT AND BASE AND THE ALKYLATION SEQUENCE

  摘要：

  对间苯二酚的二碱金属盐与甲基碘在不同条件下的烷基化进行了研究。讨论了溶剂和阳离子对间苯二酚酚根阴离子甲基化的方式和位置的影响。通过对中性和酚类分馏物的检验，并与甲氧基酚和间苯二酚的烷基化进行比较，确定了主要的甲基化序列。在非极性溶剂或水中，通过分离这类中间体，建立了各种羟基二烯酮（例如2,4,6,6-四甲基-1-羟基环己-1,4-二烯-3-酮和2,6,6-三甲基-1-羟基环己-1,4-二烯-3-酮）在形成主要产物2,2,4,6,6-五甲基环己-4-烯-1,3-二酮的过程中的中间体。2,2,4,6,6-五甲基环己-4-烯-1,3-二酮本身将在本系列的第二篇论文中详细讨论。

  DOI：

  10.1139/v65-200

文献信息

• [EN] QUINAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS QUINAZOLÉINE
  申请人：CANCER REC TECH LTD

  公开号：WO2015079251A1

  公开（公告）日：2015-06-04

  The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

  本发明涉及式I的喹唑啉化合物，其作为RET（重排基因转座）激酶酶活性的抑制剂：（式（I）），其中X，R1，R2，R3，R4，R5，R6和R7如本文所定义。本发明还涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗增殖性疾病（如癌症）以及其他涉及RET激酶活性的疾病或症状中的用途。
• PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
  申请人：Philippe Michel

  公开号：US20100028280A1

  公开（公告）日：2010-02-04

  The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

  该发明涉及一种直发角蛋白纤维的拉直过程，包括：(i)将至少两种变性剂含有的拉直组合物涂抹到角蛋白纤维上的步骤，(ii)使用加热装置将角蛋白纤维的温度升高至110至250°C的步骤。
• METHOD FOR PRODUCING CYANOGEN-HALIDE, CYANATE ESTER COMPOUND AND METHOD FOR PRODUCING THE SAME, AND RESIN COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20150299110A1

  公开（公告）日：2015-10-22

  A method for efficiently producing a cyanogen halide with suppressed side effects, and a method for producing a high-purity cyanate ester compound at a high yield includes contacting a halogen molecule with an aqueous solution containing hydrogen cyanide and/or a metal cyanide, so that the hydrogen cyanide and/or the metal cyanide is allowed to react with the halogen molecule in the reaction solution to obtain the cyanogen halide, wherein more than 1 mole of the hydrogen cyanide or the metal cyanide is used based on 1 mole of the halogen molecule, and when an amount of substance of an unreacted hydrogen cyanide or an unreacted metal cyanide is defined as mole (A) and an amount of substance of the generated cyanogen halide is defined as mole (B), the reaction is terminated in a state in which (A):(A)+(B) is between 0.00009:1 and 0.2:1.

  一种用于高效生产抑制副作用的氰卤化物，以及以高收率生产高纯度氰酸酯化合物的方法包括将卤素分子与含有氢氰酸和/或金属氰化物的水溶液接触，使得氢氰酸和/或金属氰化物与卤素分子在反应溶液中发生反应以获得氰卤化物，其中基于1摩尔卤素分子使用超过1摩尔的氢氰酸或金属氰化物，当未反应的氢氰酸或未反应的金属氰化物的物质量定义为摩尔(A)，生成的氰卤化物的物质量定义为摩尔(B)，反应在(A)：(A)+(B)介于0.00009:1和0.2:1之间的状态中终止。
• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• Calixarene compound, process for producing the same, intermediate therefor, and composition thereof
  申请人：Nishikubo Tadatomi

  公开号：US20070123736A1

  公开（公告）日：2007-05-31

  A novel calixarene compound, a method for manufacturing the same, an intermediate of the calixarene compound, and a composition comprising the same are provided. The calixarene compound is expected to be useful as an inclusion compound and, if functional groups are introduced, can be used for a curable composition and a photoresist and as an inclusion compound. The calixarene compound is shown by following formula (1): wherein R 1 to R 6 individually represent a substituted or unsubstituted alkylene group having 1 to 8 carbon atoms; X 1 to X 12 individually represent a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, a substituted or unsubstituted alkenyl group having 2 to 10 carbon atoms, a substituted or unsubstituted alkynyl group having 2 to 10 carbon atoms, a substituted or unsubstituted aralkyl group having 7 to 10 carbon atoms, a substituted or unsubstituted alkoxyl group having 1 to 10 carbon atoms, or a substituted or unsubstituted phenoxy group; Z 1 to Z 24 individually represent a hydrogen atom, a group having a polymerizable functional group, a group having an alkali-soluble group, or a substituted alkyl group having an alkyl chain with a 1-8 carbon atom content, or two adjacent Zs in combination represent a substituted or unsubstituted alkylene group having 1 to 8 carbon atoms; q 1 to q 12 individually represent an integer of 0 or 1.

  本发明提供了一种新型的杯芳烃化合物、其制造方法、杯芳烃化合物的中间体以及包含该化合物的组合物。该杯芳烃化合物预计可用作包含化合物，如果引入功能基团，则可用于可固化组合物和光阻，以及作为包含化合物。该杯芳烃化合物由以下公式（1）表示：其中，R1至R6分别表示具有1至8个碳原子的取代或未取代的烷基基团；X1至X12分别表示具有1至10个碳原子的取代或未取代的烷基基团、具有2至10个碳原子的取代或未取代的烯基基团、具有2至10个碳原子的取代或未取代的炔基基团、具有7至10个碳原子的取代或未取代的芳基烷基基团、具有1至10个碳原子的取代或未取代的烷氧基基团或取代或未取代的苯氧基；Z1至Z24分别表示氢原子、具有可聚合功能基团的基团、具有碱溶性基团的基团或具有1-8个碳原子含量的烷基链的取代烷基基团，或两个相邻的Z组合表示具有1至8个碳原子的取代或未取代的烷基基团；q1至q12分别表示0或1的整数。