2,5-二羟基-3,4-二甲氧基-苯甲酸 | 5653-45-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 2,5-二羟基-3,4-二甲氧基-苯甲酸
• 英文名称: 2,5-dihydroxy-3,4-dimethoxy-benzoic acid
• 英文别名: 2,5-Dihydroxy-3,4-dimethoxy-benzoesaeure；2,5-Dihydroxy-3,4-dimethoxybenzoic acid；2,5-dihydroxy-3,4-dimethoxybenzoic acid
• CAS: 5653-45-2
• 化学式: C₉H₁₀O₆
• 分子量: 214.175
• InChiKey: PFNZNIVJVMZUKX-UHFFFAOYSA-N

物化性质

• 熔点：
  171 °C
• 沸点：
  419.1±45.0 °C(Predicted)
• 密度：
  1.458±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,5-二羟基-3,4-二甲氧基-苯甲酸 生成 2,3-二甲氧基氢化喹啉
  参考文献：
  名称：

  303. 1：2：3：4-四羟基苯的衍生物。第五部分：香菜apiole及其衍生物的合成

  摘要：

  DOI：

  10.1039/jr9380001602
• 作为产物：
  描述：

  2,3,4-三羟基苯甲酸 在 sodium hydroxide 、 dipotassium peroxodisulfate 作用下， 以 甲醇 为溶剂， 生成 2,5-二羟基-3,4-二甲氧基-苯甲酸
  参考文献：
  名称：

  Structure–activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition

  摘要：

  Several open-chained analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were prepared for structure-activity studies. The in vitro antifungal activities of these compounds against Rhodotorula mucilaginosa IFO 0001 and the inhibition of uncoupler-stimulated respiration in bovine heart submitochondrial particles (SMP) were evaluated. Oxidative potentials were measured by cyclic voltammetry. An analogue prepared from dihexyl L-glutamate showed comparable inhibitory activity as UK-2A. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.023

文献信息

• Structure–activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition
  作者：Yoshinosuke Usuki、Noriko Adachi、Ken-Ichi Fujita、Akio Ichimura、Hideo Iio、Makoto Taniguchi

  DOI：10.1016/j.bmcl.2006.03.023

  日期：2006.6

  Several open-chained analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were prepared for structure-activity studies. The in vitro antifungal activities of these compounds against Rhodotorula mucilaginosa IFO 0001 and the inhibition of uncoupler-stimulated respiration in bovine heart submitochondrial particles (SMP) were evaluated. Oxidative potentials were measured by cyclic voltammetry. An analogue prepared from dihexyl L-glutamate showed comparable inhibitory activity as UK-2A. (c) 2006 Elsevier Ltd. All rights reserved.
• 303. Derivatives of 1 : 2 : 3 : 4-tetrahydroxybenzene. Part V. The synthesis of parsley apiole and derivatives
  作者：Wilson Baker、R. I. Savage

  DOI：10.1039/jr9380001602

  日期：——