2,6-二甲基-4-肼基喹啉 | 29125-48-2

• 物质功能分类: 医药中间体 - 杂环化合物 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2,6-二甲基-4-肼基喹啉
• 英文名称: 4-hydrazino-2,6-dimethylquinoline
• 英文别名: 4-hydrazino-2,6-dimethyl-quinoline；2,6-Dimethyl-4-Hydrazinoquinoline；(2,6-dimethylquinolin-4-yl)hydrazine
• CAS: 29125-48-2
• 化学式: C₁₁H₁₃N₃
• 分子量: 187.244
• InChiKey: XYZQGJZVMUUSGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-二甲基-4-肼基喹啉 在 盐酸 、 sodium nitrite 作用下， 生成 4-Azido-2,6-dimethylquinoline
  参考文献：
  名称：

  Savini; Massarelli; Pellerano, Il Farmaco, 1993, vol. 48, # 4, p. 515 - 528

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯-2,6-二甲基喹啉 在 一水合肼 作用下， 生成 2,6-二甲基-4-肼基喹啉
  参考文献：
  名称：

  N 1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

  摘要：

  A series of N (1)-{4-[(10S)-dihydroartemisinin-10-oxyl]}phenylmethylene-N (2)-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain-2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, H-1 NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 mu M). The best one of this series was compound 9d (IC50 = 0.15 mu M). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.

  DOI：

  10.1007/s00044-011-9854-3

文献信息

• Pellerano; Savini; Brizzi, Farmaco, Edizione Scientifica, 1985, vol. 40, # 7, p. 486 - 492
  作者：Pellerano、Savini、Brizzi

  DOI：——

  日期：——
• Cricchio; Carniti; Cietto, Farmaco, Edizione Scientifica, 1975, vol. 30, # 9, p. 704 - 720
  作者：Cricchio、Carniti、Cietto、Tamborini、Arioli

  DOI：——

  日期：——
• Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2-methylquinolines
  作者：A. A. Avetisyan、I. L. Aleksanyan、L. P. Ambartsumyan

  DOI：10.1134/s107042801003022x

  日期：2010.3

  6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]quinolines and 4-(5-ethoxy-3-methyl-1H-pyrazol-1-yl)-2-methylquinolines.
• Pellerano; Savini, Farmaco, Edizione Scientifica, 1984, vol. 39, # 8, p. 681 - 685
  作者：Pellerano、Savini

  DOI：——

  日期：——
• PELLERANO, C.;SAVINI, L., FARMACO. ED. SCI., 1984, 39, N 8, 681-685
  作者：PELLERANO, C.、SAVINI, L.

  DOI：——

  日期：——