2,6-二甲基-DL-苯丙氨酸 | 132466-22-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,6-二甲基-DL-苯丙氨酸
• 中文别名: 2-氨基-3-(2,6-二甲基苯基)丙酸；2,6-二甲基-苯丙氨酸
• 英文名称: 2,6-dimethyl-phenylalanine
• 英文别名: 2,6-Dimethyl-phenylalanin；2-Amino-3-(2,6-dimethylphenyl)propanoic acid
• CAS: 132466-22-9
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: VEQOZHOWFAVBOO-UHFFFAOYSA-N

物化性质

• 沸点：
  343.3±30.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

文献信息

• Angiotensin-1-Receptor Antagonists
  申请人：Ferring B.V.

  公开号：US20170349629A1

  公开（公告）日：2017-12-07

  In one aspect, this disclosure features compounds of formula (I) or a pharmaceutically acceptable salt thereof: AA1-Arg-Val-AA4-AA5-His-Pro-AA8-OH   (I), in which AA1, AA4, AA5, and AA8 are defined in the specification. The compounds of formula (I) can be used to treat hypertension (e.g., hypertension induced by pregnancy), preeclampsia, or a renal disease induced by pregnancy.

  在一个方面，这个披露涉及到式(I)的化合物或其药用盐： AA1-Arg-Val-AA4-AA5-His-Pro-AA8-OH (I)， 其中AA1，AA4，AA5和AA8在规范中有定义。式(I)的化合物可用于治疗高血压（例如，妊娠引起的高血压），子痫前期，或妊娠引起的肾脏疾病。
• Peptide Derivative
  申请人：Sakurada Shinobu

  公开号：US20080009448A1

  公开（公告）日：2008-01-10

  A pharmaceutical composition comprising a peptide derivative or its pharmaceutical equivalent salt having a general formula, R 1 N═C(R 2 )-AA 1 -AA 2 -AA 3 -AA 4 -Y, in which R 1 is such as a hydrogen, R 2 is such as a methyl group, Y is such as a methylamino group, AA 1 is such as a tyrosine group, AA 2 is such as a D-arginine group, AA 3 is such as a phenylalanine group, and AA 4 is such as a N-methyllysine group has analgesic activity against a variety of pains on both subcutaneous and oral administration.

  一种包括肽衍生物或其药用等效盐的药物组合物，其具有一般式R1N═C(R2)-AA1-AA2-AA3-AA4-Y，其中R1为氢，R2为甲基基团，Y为甲基氨基基团，AA1为酪氨酸基团，AA2为D-精氨酸基团，AA3为苯丙氨酸基团，AA4为N-甲基赖氨酸基团，在皮下和口服给药时对各种疼痛具有镇痛活性。
• Aniline derivatives having a polyunsaturated fatty acid residue and use thereof
  申请人：NIPPON SHOJI KAISHA, LIMITED

  公开号：EP0726247A1

  公开（公告）日：1996-08-14

  An aniline derivative of the formula (1) wherein R1 is an eicosapentaenoyl or docosahexaenoyl; R2 and R3 are each independently an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; R4 is a hydrogen atom, an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; and A is a single bond, -C(=O)NH-(CH2)n-NH- wherein n is 2 or 3, or a bivalent group of the following formula wherein m and p are each independently 0 or 1. The aniline derivative of the present invention has high inhibitory activity against and high selectivity for ACAT derived from macrophage and is useful as an agent for the prophylaxis and treatment of arteriosclerosis.

  式（1）的苯胺衍生物 其中 R1 是二十碳五烯酰基或二十二碳六烯酰基；R2 和 R3 各自独立地是具有 1 至 6 个碳原子的烷基或烷氧基，或卤素原子；R4 是氢原子、具有 1 至 6 个碳原子的烷基或烷氧基，或卤素原子；A 是单键、-C(=O)NH-(CH2)n-NH-（其中 n 是 2 或 3）或下式的二价基团 其中 m 和 p 各自独立地为 0 或 1。本发明的苯胺衍生物对来自巨噬细胞的 ACAT 具有高抑制活性和高选择性，可用作预防和治疗动脉硬化的药物。
• PEPTIDE DERIVATIVE
  申请人：Vexon, Inc.

  公开号：EP2036918A1

  公开（公告）日：2009-03-18

  A pharmaceutical composition comprising a peptide derivative or its pharmaceutical equivalent salt having a general formula, R1N=C(R2)-AA1-AA2-AA3-AA4-Y, in which R1 is such as a hydrogen, R2 is such as a methyl group, Y is such as a methylamino group, AA1 is such as a tyrosine group, AA2 is such as a D-arginine group, AA3 is such as a phenylalanine group, and AA4 is such as a N-methyllysine group has analgesic activity against a variety of pains on both subcutaneous and oral administration.

  一种药物组合物，包含一种肽衍生物或其药物等效盐，其通式为R1N=C(R2)-AA1-AA2-AA3-AA4-Y，其中R1为氢，R2为甲基，Y为甲氨基、 AA1 是酪氨酸基团，AA2 是 D-精氨酸基团，AA3 是苯丙氨酸基团，AA4 是 N-甲基赖氨酸基团，在皮下和口服给药时对多种疼痛具有镇痛活性。
• ENANTIO-SELECTIVE SYNTHESIS OF NON-NATURAL AMINO ACIDS
  申请人：Universita' Degli Studi "G. d'Annunzio" Chieti-Pescara

  公开号：EP3061753A1

  公开（公告）日：2016-08-31

  An enantio-selective process for the preparation of unnatural aromatic amino acids with restricted structure using non-chiral catalysts from natural amino acid and alkyl esters is disclosed.

  本发明公开了一种利用非手性催化剂从天然氨基酸和烷基酯制备结构受限的非天然芳香族氨基酸的对映选择性工艺。