PROCESS FOR THE PURIFICATION OF ALPHA,OMEGA-DIIODOPERFLUORINATED COMPOUNDS
申请人:Politecnico di Milano
公开号:EP2181082A2
公开(公告)日:2010-05-05
[EN] F-18-LABELED THIA FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] ACIDES GRAS THIA ETIQUETES AU F-18 ET PROCEDES DE FABRICATION ET D'UTILISATION CORRESPONDANTS
申请人:UNIV DUKE
公开号:WO2000063216A1
公开(公告)日:2000-10-26
Sulfur heteroatom substitution at the C4 position of 18F-labeled fatty acids yields a tracer that is retained in proportion to the beta-oxidation rates in mammalian tissue, particularly hypoxic myocardium. Most preferably, the invention is embodied in an [18F]fluoro-4-thia-fatty acid having a chain length of between 8 to 20 carbon atoms. The 18F-labeled 4-thia fatty acids of this invention find particular utility the radiolabelling of tissue sites (e.g., myocardium) for purposes of positron emission tomography.
[EN] PROCESS FOR THE PURIFICATION OF ALPHA,OMEGA-DIIODOPERFLUORINATED COMPOUNDS<br/>[FR] PROCÉDÉ DE PURIFICATION DE COMPOSÉS ALPHA-OMÉGA-DIIODOPERFLUORÉS
申请人:MILANO POLITECNICO
公开号:WO2009007302A2
公开(公告)日:2009-01-15
The invention concerns a process for purifying α,ω-diiodoρerfluorinatcd compounds of formula 1-(CF2CF2Y)m-I comprising contacting an impure α,ω-diiodopcrfluorinated compound with a suitable sequestering agent, with formation of a reversible adduct and separating the α,ω- diiodoperfluorinated compound from the adduct itself. Diammonium dihalogenids of the general formula [R1,2,3N-(CH2)n-NR4,5,6]2*2X (R1-6=alkyl C1-C6n=8-26, X=I,Br, Cl) also called 'methonium compounds' are the preferred sequestering agents.