4-oxo-1-iodo-trans-1-octene | 65989-30-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-oxo-1-iodo-trans-1-octene
• 英文别名: trans-1-Iodo-oct-1en-4one；4-Oxo-1-iod-trans-1-octen；(E)-1-Jod-1-octen-4-on；(E)-1-iodooct-1-en-4-one
• CAS: 65989-30-2
• 化学式: C₈H₁₃IO
• 分子量: 252.095
• InChiKey: SWRZXKXCHWOPHU-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-oxo-1-iodo-trans-1-octene 生成 4-hydroxy-4-vinyl-1-iodo-trans-1-octene
  参考文献：
  名称：

  FLOYD, MIDDLETON B. (JR);WEISS, MARTIN J.;GRUDZINSKAS, C. V.;CHEN, L.

  摘要：

  DOI：
• 作为产物：
  描述：

  辛-1-炔-4-醇 在 sodium hydroxide 、 三甲基氯硅烷 、 碘 、 sodium acetate 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 N-甲基乙酰胺 、 二氯甲烷 、 水 、 溶剂黄146 、 丙酮 、 甲苯 、 苯 为溶剂， 生成 4-oxo-1-iodo-trans-1-octene
  参考文献：
  名称：

  15-Deoxy-16-hydroxy-16-substituted-3-thia-prostanoic acids

  摘要：

  这份披露描述了新颖的15-去氧-16-羟基-16-取代前列酸及其同分异构体，具有作为支气管扩张剂、降压剂以及控制过多胃酸分泌的用途。

  公开号：

  US04131737A1

文献信息

• 1-Substituted-1-oxo-prostane-derivatives of the E, A and F series
  申请人：American Cyanamid Company

  公开号：US04297516A1

  公开（公告）日：1981-10-27

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: ##STR1## wherein R is C.sub.1 to C.sub.6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR.sub.16, SR.sub.16, F, or Cl, and R.sub.16 is C.sub.1 to C.sub.6 alkyl.

  本发明公开的药物活性前列腺素衍生物属于E、F或A系列，在α链的末端亚甲基碳上有一个取代基，该取代基从以下组中选择：##STR1## 其中R是C.sub.1至C.sub.6烷基，和苯基或苯基，苯基上带有1个或多个取代基，该取代基从以下组中选择：C.sub.1-C.sub.4烷基，OR.sub.16，SR.sub.16，F或Cl，R.sub.16是C.sub.1至C.sub.6烷基。
• 1-Hydroxymethyl-1-oxo-prostane-derivatives of the E, A and F-series
  申请人：American Cyanamid Company

  公开号：US04254036A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, C.sub.1 -C.sub.4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C.sub.1 -C.sub.4, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1##其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，二C.sub.1 -C.sub.4-烷基氨基，C.sub.1 -C.sub.4烷氧基，苯基或苯基，其上取代基来自C.sub.1 -C.sub.4，OR，SR，F或Cl的组成，其中R如前所定义。
• 1-Hydroxymethyl-1-1-oxo prostane derivatives of the E and F series
  申请人：American Cyanamid Company

  公开号：US04254285A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, di-C.sub.1 -C.sub.4 -alkylamino, and phenyl orphenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1## 其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，C.sub.1 -C.sub.4烷氧基，二C.sub.1 -C.sub.4-烷基氨基，以及苯基或苯基取代物，所述苯基或苯基取代物中取代基选择自C.sub.1 -C.sub.4烷基，OR，SR，F或Cl的组成，其中R如前所定义。
• 11-(2-Hydroxyethylthio) prostenoic acid E and F series derivatives
  申请人：American Cyanamid Company

  公开号：US04218566A1

  公开（公告）日：1980-08-19

  This disclosure describes certain 11-(2-hydroxyethylthio) prostenoic acid E and F series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.

  这份披露描述了某些11-(2-羟乙基硫基)前列腺酸E和F系列衍生物，以及它们的中间体，可用作支气管扩张剂和炎症介质释放抑制剂。
• 15-Deoxy-16-hydroxy-16-vinyl or cyclopropyl prostan-1-ols of the E, A
  申请人：American Cyanamid Company

  公开号：US04206151A1

  公开（公告）日：1980-06-03

  This disclosure describes novel 15-deoxy-16 hydroxy-16-substituted prostanoic acid analogs in which the C-1 carboxyl is replaced by a primary alcohol and carboxylic acid esters, carbonates and carbomates thereof. The prostanoic carbinols and carboxylic acid esters thereof described herein have utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.

  这份披露描述了一种新型的15-去氧-16 羟基-16-取代前列腺烯酸类似物，其中C-1 羧基被一元醇和羧酸酯、碳酸酯和碳酸酯取代。本文描述的前列腺烯醇和羧酸酯具有作为支气管扩张剂、降压剂以及控制过度胃酸分泌的用途。