ethyl (4-nitrobenzoyl)cyanoacetate | 6750-99-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl (4-nitrobenzoyl)cyanoacetate
• 英文别名: 2-cyano-3-(4-nitro-phenyl)-3-oxo-propionic acid ethyl ester；2-Cyan-3-(4-nitro-phenyl)-3-oxo-propionsaeure-aethylester；4-Nitro-benzoylmalonsaeure-aethylester-nitril；4-Nitro-benzoylcyanessigsaeure-aethylester；Cyan-(4-nitrobenzoyl)-essigsaeureethylester；Ethyl 2-cyano-3-(4-nitrophenyl)-3-oxopropanoate
• CAS: 6750-99-8
• 化学式: C₁₂H₁₀N₂O₅
• 分子量: 262.222
• InChiKey: UKBSTFRRKWGHPS-UHFFFAOYSA-N

物化性质

• 熔点：
  160-161 °C
• 沸点：
  428.4±35.0 °C(Predicted)
• 密度：
  1.337±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  113
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl (4-nitrobenzoyl)cyanoacetate 在 Pt/Al₂O₃ 氢气 、 sodium carbonate 作用下， 以 水 为溶剂， 20.0~35.0 ℃ 、2.0 MPa 条件下， 以99%的产率得到ethyl (4-aminobenzoyl)cyanoacetate
  参考文献：
  名称：

  摘要：

  Improved procedures have been proposed for fast and selective hydrogenation of aromatic nitro compounds with the goal of obtaining practically important amines.

  DOI：

  10.1023/a:1012491515950
• 作为产物：
  描述：

  4-硝基苯甲酰氯 在 三溴化磷 、 三乙胺 作用下， 生成 ethyl (4-nitrobenzoyl)cyanoacetate
  参考文献：
  名称：

  Application of time-variable feedback to the input amplifier of pulse magnetic resonance spectrometers: Experimental studies

  摘要：

  Experimental research on the improvement of the sensitivity and time resolution of pulsed magnetic resonance spectrometers is discussed. It is shown that application of a time-variable feedback of a signal to the input of the receiver amplifier can decouple the "fixed" relationship between the quality factor Q and the ringdown time of the resonance system. Experiments were performed with low-frequency, radio-frequency and microwave pulse-type magnetic resonance receivers. Modifications of an S/C-band electron spin echo modulation spectrometer carried out to check the "time-variable feedback" performance are described. It is demonstrated that the application of a time-variable feedback can significantly reduce the ringdown time and improve the recovery properties of the magnetic resonance receiver system. It is also demonstrated that the time-variable feedback can improve the overall receiver sensitivity due to the fact that the working bandwidth of the resonance system can be optimized separately for the transmitting and the receiving mode. Signal values could be increased at least three times and the signal-to-noise ratio about 1.5-2 times. The largest improvement is achieved with the initially overcoupled resonator. Experimental spectra of test samples for different settings of the time-variable feedback are shown.

  DOI：

  10.1007/bf03166126

文献信息

• Substitution controlled aryne insertion: synthesis of diarylmethane/chromones
  作者：Jadhav Rahul Dhanaji、Polasani Samatha、Silver Raju、Prathama S. Mainkar、Raju Adepu、Srivari Chandrasekhar

  DOI：10.1039/d2cc05992d

  日期：——

  Aryne insertion reaction with 2-aroyl malonates/cyanoesters lead to the formation of diarylmethane or chromones depending on the substitution on the aryne ring. The presence of an electronegative atom at the ortho position of arynes generates chromones, whereas other arynes lead to the formation of diarylmethanes, via a cascade double aryne insertion.

  芳炔与 2-芳酰基丙二酸酯/氰酸酯的插入反应导致二芳基甲烷或色酮的形成，具体取决于芳炔环上的取代。在芳烃的邻位存在电负性原子会产生色酮，而其他芳烃通过级联双芳烃插入导致二芳基甲烷的形成。
• Stepanow; Wul'fson, 1959, # 1, p. 222,226
  作者：Stepanow、Wul'fson

  DOI：——

  日期：——
• Grigat,E.; Puetter,R., Chemische Berichte, 1967, vol. 100, # 4, p. 1385 - 1388
  作者：Grigat,E.、Puetter,R.

  DOI：——

  日期：——
• Dornow; Fust, Chemische Berichte, 1954, vol. 87, p. 985,989
  作者：Dornow、Fust

  DOI：——

  日期：——
• Application of time-variable feedback to the input amplifier of pulse magnetic resonance spectrometers: Experimental studies
  作者：A. V. Koptioug、E. J. Reijerse、A. A. K. Klaassen

  DOI：10.1007/bf03166126

  日期：2002.12

  Experimental research on the improvement of the sensitivity and time resolution of pulsed magnetic resonance spectrometers is discussed. It is shown that application of a time-variable feedback of a signal to the input of the receiver amplifier can decouple the "fixed" relationship between the quality factor Q and the ringdown time of the resonance system. Experiments were performed with low-frequency, radio-frequency and microwave pulse-type magnetic resonance receivers. Modifications of an S/C-band electron spin echo modulation spectrometer carried out to check the "time-variable feedback" performance are described. It is demonstrated that the application of a time-variable feedback can significantly reduce the ringdown time and improve the recovery properties of the magnetic resonance receiver system. It is also demonstrated that the time-variable feedback can improve the overall receiver sensitivity due to the fact that the working bandwidth of the resonance system can be optimized separately for the transmitting and the receiving mode. Signal values could be increased at least three times and the signal-to-noise ratio about 1.5-2 times. The largest improvement is achieved with the initially overcoupled resonator. Experimental spectra of test samples for different settings of the time-variable feedback are shown.