申请人:Osaka Organic Chemical Industry Ltd.
公开号:EP3296314A1
公开(公告)日:2018-03-21
Provided is a protein aggregation inhibitor capable of inhibiting aggregation of a protein even when the protein is heated, and further, capable of inhibiting a decrease in the protein activity even when the protein is heated, which characteristically contains a sulfobetaine polymer obtained by polymerizing monomer components containing sulfobetaine monomer represented by the formula (I):
wherein R1 is a hydrogen atom or a methyl group, R2 is an alkylene group having a carbon number of 1 - 4, R3 is an alkyl group having a carbon number of 1 - 4, R4 is an alkylene group having a carbon number of 1 - 4, and X is an -NH- group or an - O- group.
本发明提供了一种蛋白质聚集抑制剂,即使在加热蛋白质的情况下也能抑制蛋白质的聚集,而且即使在加热蛋白质的情况下也能抑制蛋白质活性的降低,其特征在于含有一种磺基甜菜碱聚合物,该聚合物是通过聚合含有由式(I)表示的磺基甜菜碱单体的单体成分而获得的:
其中 R1 是氢原子或甲基,R2 是碳原子数为 1-4 的亚烷基,R3 是碳原子数为 1-4 的烷基,R4 是碳原子数为 1-4 的亚烷基,X 是-NH-基团或-O-基团。