4-chloro-2,8-dimethylquinolin-5-amine | 157493-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-chloro-2,8-dimethylquinolin-5-amine
• CAS: 157493-71-5
• 化学式: C₁₁H₁₁ClN₂
• mdl: MFCD04061321
• 分子量: 206.675
• InChiKey: YIRDTSIVFDYDSR-UHFFFAOYSA-N

物化性质

• 沸点：
  347.7±37.0 °C(Predicted)
• 密度：
  1.263±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-2,8-dimethylquinolin-5-amine 在 对甲苯磺酸 作用下， 以 邻二甲苯 为溶剂， 反应 2.5h， 生成 6,8-dimethyl-1-(o-methoxphenyl)-2',6'-di-tert-butyl-2,3-dihydroquinazoline-2-spiro-4'-cyclohexa-2',5'-dien-1'-one
  参考文献：
  名称：

  Komissarov, V. N.; Gruzdeva, E. N.; Kharlanov, V. A., Russian Journal of Organic Chemistry, 1993, vol. 29, # 10.2, p. 1688 - 1691

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯-2,8-二甲基喹啉 在 硫酸 、 硝酸 、 铁粉 、 溶剂黄146 作用下， 以 邻二甲苯 为溶剂， 反应 9.0h， 生成 4-chloro-2,8-dimethylquinolin-5-amine
  参考文献：
  名称：

  Komissarov, V. N.; Gruzdeva, E. N.; Kharlanov, V. A., Russian Journal of Organic Chemistry, 1993, vol. 29, # 10.2, p. 1688 - 1691

  摘要：

  DOI：

文献信息

• 3,5-Di-tert-butyl-1,2-benzoquinone in the synthesis of quinolino[4,5-bc][1,5]benzoxazepines, aminophenols, and phenoxazines
  作者：Zyong Ngia Bang、V. N. Komissarov、Yu. A. Sayapin、V. V. Tkachev、G. V. Shilov、S. M. Aldoshin、V. I. Minkin

  DOI：10.1134/s1070428009030178

  日期：2009.3

  Reaction of 3,5-di-tert-butyl-1,2-benzoquinone with 5-amino-4-chloroquinolines gave derivatives of a new fused heterocyclic system, substituted quinolino[4,5-bc][1,5]benzoxazepines. The molecular structure of 9,11-di-tert-butyl-2,4,6-trimethyl-7H-quinolino[4,5-bc][1,5]benzoxazepine was determined by X-ray analysis. 3,5-Di-tert-butyl-1,2-benzoquinone reacted with o-nitro-, o-acyl-, and o-methoxycarbonylanilines and some amino-substituted nitrogen-containing heterocycles to form the corresponding sterically hindered N-aryl-(hetaryl)-o-aminophenols. Di-tert-butyl-substituted phenoxazines were obtained as a result of thermal cyclization of intermediately formed quinone imines.
• Postupnaya, E.N.; Komissarov, V.N.; Kharlanov, V.A., Russian Journal of Organic Chemistry, 1993, vol. 29, # 9, p. 1596 - 1597
  作者：Postupnaya, E.N.、Komissarov, V.N.、Kharlanov, V.A.

  DOI：——

  日期：——
• Synthesis, structures, and properties of spiro[6-azaperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-one derivatives
  作者：V. N. Komissarov、E. N. Gruzdeva、L. P. Olekhnovich、G. S. Borodkin、V. N. Khrustalev、S. V. Lindeman、Yu. T. Struchkov、V. A. Kogan、V. I. Minkin

  DOI：10.1007/bf02503788

  日期：1997.11

  The reaction of 5-amino-4-chloroquinolines with 4-amino-2,6-di-tert-butylphenol yielded derivatives of spiro[6-azaperimidine-2,4'-cyclohexa-2',5'-dien]-1'-one, which exhibit photo-and thermochromic properties in solutions. The structure of 2',6'-di-tert-butyl-5,7,9-trimethylspiro[6-aza-2,3-dihydroperimidine-2,4'-cyclohexa-2',5'-dien]-1'-one was established by X-ray diffraction study. The ring-chain isomerization of 2',6'-di-tert-butyl-5,7-dimethyl- and 2',6'-di-tert-butyl-5,7,8-trimethylspiro[6-aza-2,3-dihydroperimidine-2,4'- cyclohexa-2',5 -dien]-1'-ones was studied by dynamic NMR spectroscopy.
• Komissarov, V. N.; Gruzdeva, E. N.; Kharlanov, V. A., Russian Journal of Organic Chemistry, 1993, vol. 29, # 10.2, p. 1688 - 1691
  作者：Komissarov, V. N.、Gruzdeva, E. N.、Kharlanov, V. A.、Kogan, V. A.、Minkin, V. I.

  DOI：——

  日期：——