5,9-dimethyl-dec-8-en-5-ol | 87386-18-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5,9-dimethyl-dec-8-en-5-ol
• 英文别名: Δ²-Dimethyl-decenol-(6)；5,9-dimethyldec-8-en-5-ol
• CAS: 87386-18-3
• 化学式: C₁₂H₂₄O
• 分子量: 184.322
• InChiKey: JGUGXFFAFRLFMK-UHFFFAOYSA-N

物化性质

• 沸点：
  99 °C(Press: 7 Torr)
• 密度：
  0.847±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5,9-dimethyl-dec-8-en-5-ol 生成 6-甲基-5-庚烯-2-酮
  参考文献：
  名称：

  Utilizing Propensity Scores to Estimate Causal Treatment Effects with Censored Time-Lagged Data

  摘要：

  Observational studies frequently are conducted to compare long-term effects of treatments. Without randomization, patients receiving one treatment are not guaranteed to be prognostically comparable to those receiving another treatment. Furthermore, the response of interest may be right-censored because of incomplete follow-up. Statistical methods that do not account for censoring and confounding may lead to biased estimates. This article presents a method for estimating treatment effects in nonrandomized studies with right-censored responses. We review the assumptions required to estimate average causal effects and derive an estimator for comparing two treatments by applying inverse weights to the complete cases. The weights are determined according to the estimated probability of receiving treatment conditional on covariates and the estimated treatment-specific censoring distribution. By utilizing martingale representations, the estimator is shown to be asymptotically normal and an estimator for the asymptotic variance is derived. Simulation results are presented to evaluate the properties of the estimator. These methods axe applied to an observational data set of acute coronary syndrome patients from Duke University Medical Center to estimate the effect of a treatment strategy on the mean 5-year medical cost.

  DOI：

  10.1111/j.0006-341x.2001.01207.x
• 作为产物：
  描述：

  溴丁基-镁 、 6-甲基-5-庚烯-2-酮 在 乙醚 作用下， 生成 5,9-dimethyl-dec-8-en-5-ol
  参考文献：
  名称：

  DNA adducts and human atherosclerotic lesions

  摘要：

  It has been hypothesized that mutational events may be involved in the atherogenetic process and that at least a portion of atherosclerotic plaques may be the results of monoclonal proliferation of a single mutated smooth muscle cell (SMC). Therefore, atherosclerosis may be similar to carcinogenesis and may have an environmental etiology. We have analyzed bulky-aromatic DNA adducts in human thoracic aortas from mate subjects, aged between 30-60 years, who died suddenly or accidentally, and who had been examined by autopsy within 24 h after death. We found significantly (P < 0.001) higher DNA adduct levels in the samples from subjects with frequent atherosclerotic changes in the whole body ("Cases", N = 76) compared with those having few atherosclerotic changes ("Controls", N = 57). We also observed a significantly elevated weight of heart and plasma levels of total and LDL cholesterol in "Cases" vs "Controls". Significant differences in DNA adduct levels between smokers and nonsmokers were observed in "Controls" only. Multivariate linear regression analyses with age-adjusted data confirmed a significant influence of LDL cholesterol (P < 0.001), vitamin A (P < 0.01), smoking behavior (P < 0.05; evaluated as plasma cotinine levels) and NAT2 genotypes (P < 0.05) on bulky-aromatic DNA adduct levels. The induction of DNA adducts suggests that alterations at the DNA level may contribute to the development of atherosclerosis. Furthermore, atherogenesis and carcinogenesis may share a similar etiology, i.e. genotoxic action of environmental chemicals.

  DOI：

  10.1078/1438-4639-00072

文献信息

• Ho, Tse-Lok, Synthetic Communications, 1983, vol. 13, # 9, p. 769 - 772
  作者：Ho, Tse-Lok

  DOI：——

  日期：——
• Levallois,C. et al., Bulletin de la Societe Chimique de France, 1967, p. 805 - 808
  作者：Levallois,C. et al.

  DOI：——

  日期：——
• Grignard; Escourrou, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1923, vol. 176, p. 1860
  作者：Grignard、Escourrou

  DOI：——

  日期：——
• Escourrou, Bulletin de la Societe Chimique de France, 1926, vol. <4> 39, p. 1465
  作者：Escourrou

  DOI：——

  日期：——
• Escourrou, Bulletin de la Societe Chimique de France, 1928, vol. <4>43, p. 1108
  作者：Escourrou

  DOI：——

  日期：——