Rhodium-phosphine chiral hydrogenation catalysis of acetophenone,
申请人:The Procter & Gamble Company
公开号:US04440936A1
公开(公告)日:1984-04-03
The chiral phosphine ligand (R)-1,2-bis(diphenylphosphino)-1-cyclohexylethane, when complexed to Rh(I), functions as a superior chiral hydrogenation catalyst. The chiral phosphine ligand is more stereochemically rigid than previous compounds; consequently, virtually optically pure materials can be produced from the chiral hydrogenation of prochiral compounds using the catalyst of this invention. This catalyst is especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.
Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization
作者:Pei Che Soon、Xiang Xu、Boyang Zhang、Francesca Gruppi、James W. Canary、Alexej Jerschow
DOI:10.1039/c3cc40426a
日期:——
Several important neurotransmitter precursors were hyperpolarized via homogeneous hydrogenation with parahydrogen. Polarization enhancement was achieved for 1H and 13C spins by several orders of magnitude compared to thermal spectra. Such large signal enhancements of these molecules could facilitate neurotransmitter studies.