2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯 | 1160861-53-9

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯
• 中文别名: 2-(二叔丁基膦)-3,6-二甲氧基-2'-4'-6'三-1-丙基-1,1'-双苯基；2-（二叔丁基膦）-3,6-二甲氧基-2'-4'-6'三-1-丙基-1，1'-双苯基；2 - (二叔丁基膦)-3,6-二甲氧基-2'-4'-6'三- 1 -丙基- 1,1'-双苯基
• 英文名称: t-BuBrettPhos
• 英文别名: 2-(di-tert-butylphosphino)-2',4',6'-triisopropyl-3,6-dimethoxy-1,1'-biphenyl；2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-3,6-dimethoxy-1,1′-biphenyl；t-butylBrettPhos；2-(di-t-butylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl；tert-butyl brettphos；di-tert-butyl (2’,4’,6’-triisopropyl-3,6-dimethoxy-[1,1’-biphenyl]-2-yl)phosphine；2-(di-tert-butylphosphino)-2’,4’,6’- triisopropyl-3,6-dimethoxy-1,1’-biphenyl；2-(di-t-butylphosphino)-3,6-dimethoxy-2’,4’,6’-tri-i-propyl-1,1’-biphenyl；di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine；RockPhos；2-(di-tert-butylphosphino)-2’,4’,6’-triisopropyl-3,6-dimethoxy-1,1‘-biphenyl；2-(di-t-butylphosphino)-2′,4′,6′- triisopropyl-3,6-dimethoxy-1,1′-biphenyl；di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane；di-tert-butyl({3,6-dimethoxy-2-[2,4,6-tris(propan-2-yl)phenyl]phenyl})phosphane；di-tert-butyl (2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine；di-tert-butyl(2′,4′,6′- triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine；di-tert-butyl(2’,4’,6’-triisopropyl-3,6-dimethoxy-[1,1‘-biphenyl]-2-yl)phosphine；2-(di-tert-butylphosphino)-2’,4’,6’- triisopropyl-3,6-dimethoxy-1,1'-biphenyl；3,6-dimethoxy-[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]bis(1,1 dimethylethyl)phosphine；2-di-tert-butylphosphine-2',4',6'-triisopropyl-3,6-dimethoxy-1,1'-biphenyl；[3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl) [1,1′-biphenyl]-2-yl]bis(1,1-dimethylethyl)phosphine；di-tert-butyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphane；2-(di-tert-butylphosphino)-2″,4″,6″-triisopropyl-3,6-dimethoxy-1,1″-biphenyl；2-(di-tert-butylphosphino)-3,6-dimethoxy-2′,4′,6′triisopropyl-1,1′-biphenyl；di-t-butyl-[3,6-dimethoxy-2-(2,4,6-triisopropylphenyl)phenyl]phosphane；Bu^tBrettPhos；ditert-butyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
• CAS: 1160861-53-9
• 化学式: C₃₁H₄₉O₂P
• 分子量: 484.703
• InChiKey: REWLCYPYZCHYSS-UHFFFAOYSA-N

物化性质

• 熔点：
  166-170°C
• 沸点：
  534.9±50.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  存放于惰性气体中，避免与空气接触。

SDS

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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : tBuBrettPhos
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 1160861-53-9

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SECTION 2: Hazards identification
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
The product does not need to be labelled in accordance with EC directives or respective national laws.
Other hazards - none

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SECTION 3: Composition/information on ingredients
Substances
Synonyms : t-BuBrettPhos
[3,6-Dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]bis(1,1-
dimethylethyl)phosphine
Formula : C31H49O2P
Molecular Weight : 484,69 g/mol
CAS-No. : 1160861-53-9
No components need to be disclosed according to the applicable regulations.

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SECTION 4: First aid measures
Description of first aid measures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

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SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Oxides of phosphorus
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapours, mist or gas.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.

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SECTION 7: Handling and storage
Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Handle and store under inert gas.
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous
substances, and to the specific work-place., The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

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SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: 166 - 170 °C
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

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SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

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SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

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SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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SECTION 14: Transport information
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

2-二叔丁基膦-3,6-二甲氧基-2’,4’,6’-三异丙基-1,1'-联苯是一种重要的有机膦类配体，与过渡金属络合后可以作为有机偶联反应的催化剂，在合成天然产物、药物、功能材料、液晶分子以及生物活性化合物中有着广泛的应用。

制备

在氩气保护下，将干燥后的反应器加入四氢呋喃0.5L和金属镁(26g,1.1mol)。然后在-10～10℃条件下分批次加入二叔丁基氯化膦(180g,1mol)，反应持续2小时后，继续加入镍催化剂Ni(acac)2(13g,0.05mol)和2-溴-3,6-二甲氧基-2’,4’,6’-三异丙基-1,1’-联苯(419g,1mol)，随后将反应体系升温至80℃，进行12小时的反应。完成后加入饱和氯化铵水溶液500mL淬灭反应，经过分液、有机相浓缩除去溶剂，并在甲醇中重结晶得到目标产物2-二叔丁基膦-3,6-二甲氧基-2’,4’,6’-三异丙基-1,1'-联苯440g，收率90%。

反应信息

• 作为反应物：
  描述：

  2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯 在 硫酸 、 发烟硫酸 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.58h， 以98%的产率得到
  参考文献：
  名称：

  通过区域选择性磺化制备两亲性联芳基单膦配体

  摘要：

  两亲配体因其在水存在下促进有机金属反应的能力而受到重视。提出了一系列市售联芳基单膦的区域选择性磺化以产生两亲配体。在此一步方案中，仔细控制温度和发烟硫酸的添加量，以高产率获得磺化联芳基单膦配体，其区域选择性为 >95%，无需色谱纯化。

  DOI：

  10.1021/acs.orglett.0c04001
• 作为产物：
  描述：

  magnesium,1,3,5-tri(propan-2-yl)benzene-6-ide,bromide 在 正丁基锂 、 1,2-二溴乙烷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 39.7h， 生成 2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯
  参考文献：
  名称：

  BrettPhos 和 RockPhos 型双芳基膦配体的改进合成

  摘要：

  介绍了制备基于联苯的膦配体t - BuBrettPhos、RockPhos 和 BrettPhos 的改进方法。新方法的特点是使用格氏试剂和催化量的铜，优于以前需要使用叔丁基锂和化学计量铜的方法。具体而言，使用危险性较低的试剂提供了更安全的过程，而使用催化量的铜可以高产率地分离纯产品。这些改进对于这些配体的大规模制备尤为重要。

  DOI：

  10.1002/adsc.201200398
• 作为试剂：
  描述：

  5,7-dichloro-3-ethyl-3H-imidazo[4,5-b]pyridine 在 2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯 、 [(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl)-2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate 、 caesium carbonate 、 N,N-二异丙基乙胺 作用下， 以 正丁醇 为溶剂， 反应 2.0h， 生成 (S)-tert-butyl 3-(3-ethyl-5-((2R,3S)-2-hydroxypentan-3-ylamino)-3H-imidazo[4,5-b]pyridin-7-ylamino)pyrrolidine-1-carboxylate
  参考文献：
  名称：

  2,6,9-TRISUBSTITUTED PURINES

  摘要：

  Compounds having the structure of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent cyclin-dependent kinase 2 (CDK2)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

  公开号：

  WO2024127350A1

文献信息

• [EN] TRIAZOLE AGONISTS OF THE APJ RECEPTOR<br/>[FR] TRIAZOLES AGONISTES DU RÉCEPTEUR APJ
  申请人：AMGEN INC

  公开号：WO2016187308A1

  公开（公告）日：2016-11-24

  Compounds of Formula I and Formula II, pharmaceutically acceptable salt the