2-氧代丙酸钙盐 | 52009-14-0

• 物质功能分类: 有机原料 - 有机金属盐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: 2-氧代丙酸钙盐
• 中文别名: 丙酮酸钙；焦葡萄酸钙
• CAS: 52009-14-0
• 化学式: C3H4CaO3
• 分子量: 128.14
• InChiKey: QUCGULSUYXHQLW-UHFFFAOYSA-N

物化性质

• 熔点：
  >245°C (dec.)
• 密度：
  890 at 25℃
• 溶解度：
  水（少量，加热）
• LogP：
  -1.24 at 25℃ and pH7
• 稳定性/保质期：

  如果按照规格使用和储存，则不会分解，也未有已知危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.72
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S26
• 危险类别码：
  R20/21/22
• WGK Germany：
  1
• 海关编码：
  2918300090
• 危险类别：
  4.3
• 包装等级：
  II

SDS

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Section 1. Chemical Product and Company Identification
Calcium pyruvate Catalog
C2262, YY373
Common Name/
Number(s).
Trade Name
CAS# 52009-14-0
Manufacturer
RTECS Not available.
SPECTRUM CHEMICAL MFG. CORP.
TSCA TSCA 8(b) inventory: No
products were found.
Commercial Name(s) Not available.
CI# Not available.
Synonym Not available.
IN CASE OF EMERGENCY
Not available.
Chemical Name
Chemical Family Not available. CALL [phone]
C6H6O6Ca.xH2O
Chemical Formula
SPECTRUM CHEMICAL MFG. CORP.

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Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3)
Name CAS # % by Weight
1) Calcium pyruvate 52009-14-0 100
Toxicological Data Calcium pyruvate
on Ingredients LD50: Not available.
LC50: Not available.

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Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation (lung irritant).
Slightly hazardous in case of skin contact (permeator).
Potential Chronic Health CARCINOGENIC EFFECTS: Not available.
Effects MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Calcium pyruvate

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Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,
keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Skin Contact After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
Wash contaminated clothing before reusing.
Serious Skin Contact Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
Inhalation Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation Not available.
Ingestion Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion Not available.

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
These products are carbon oxides (CO, CO2). Some metallic oxides.
Products of Combustion
Fire Hazards in Presence of Not available.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Not available.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards

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Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Calcium pyruvate

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Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable
protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek
medical attention and show the label when possible. Avoid contact with skin and eyes
Storage Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
and away from strong oxidizing agents.

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Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid. Odor Not available.
Taste Not available.
214.19 g/mole
Molecular Weight
Color Off-white.
pH (1% soln/water) Not available.
Boiling Point Not available.
Melting Point Decomposes. (150°C or 302°F)
Critical Temperature Not available.
Specific Gravity Not available.
Not applicable.
Vapor Pressure
Vapor Density Not available.
Volatility Not available.
Odor Threshold Not available.
Water/Oil Dist. Coeff. Not available.
Not available.
Ionicity (in Water)
Dispersion Properties See solubility in water.
Partially soluble in cold water.
Solubility

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Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability Temperature Not available.
Not available.
Conditions of Instability
Incompatibility with various Not available.
substances
Calcium pyruvate
Corrosivity Non-corrosive in presence of glass.
Special Remarks on Not available.
Reactivity
Special Remarks on Not available.
Corrosivity
Polymerization No.

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Section 11. Toxicological Information
Routes of Entry Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on Hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant).
Humans Slightly hazardous in case of skin contact (permeator).
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on Not available.
Chronic Effects on Humans
Special Remarks on other Not available.
Toxic Effects on Humans

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Section 12. Ecological Information
Ecotoxicity Not available.
BOD5 and COD Not available.
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The products of degradation are more toxic.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation

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Section 13. Disposal Considerations
Waste Disposal

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Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Identification Not applicable.
Special Provisions for Not applicable.
Transport
Calcium pyruvate
DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: No products were found.
Federal and State
Regulations
California California prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations Not available..
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC) R36/37/38- Irritating to eyes,
respiratory system and skin.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Calcium pyruvate

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

丙酮酸及其盐 丙酮酸钙

概述 丙酮酸钙是丙酮酸的钙盐。这种化合物非常稳定，呈现白色结晶粉末状，无味且接近中性。它微溶于水，而在自然条件下是一种无色带有刺激性气味的液体，沸点为165℃（分解）。目前在中国只能通过化学合成生产，所得的产品均为工业原料级别，以消旋体形式存在。人体内只有左旋丙酮酸能被吸收，而大部分用于医药和减肥的产品需从国外进口，日本在这方面拥有领先技术。

用途 丙酮酸钙作为药物原料及食品添加剂，能够加速脂肪消耗、减轻体重，并增强身体耐力，提高竞技表现。此外，它还对心脏有特殊保护作用，减少心脏病或局部缺血损伤的风险；同时具有清除体内自由基和抑制自由基生成的显著效果。

化学性质 丙酮酸钙虽然含钙量不高，但其独特的分子结构使其进入人体时不会增加肝肾负担。它有助于有机物代谢，既减肥又不影响蛋白质储存。

丙酮酸

概述 丙酮酸是人体内的一种成分，在糖、脂肪等代谢过程中扮演重要角色，并作为碳水化合物代谢的中间产物之一。其物理和化学性质包括浅黄色至黄色透明液体，具有醋酸气味及酸味。天然存在于薄荷和蔗糖发酵液中。

化学特性

丙酮酸又名乙酰甲酸或焦性葡萄酸（2-氧代丙酸），相对分子质量为88.06。它在不同压力下的熔点、沸点变化范围广泛，从13.8℃至165℃不等，并且具有高度反应性。此外，在生物体内参与糖代谢、胶质合成及氨基酸、蛋白质的生化过程。

制备方法

丙酮酸可通过多种方式制备：

• 以乳酸酯为原料进行气相或液相氧化，再水解。
• 使用酒石酸作为起始物加入硫酸氢钾和钠，在210~220℃下加热脱氢后再精馏提纯。
• 利用2,2-二氯丙酸与NaOH反应并调节pH值至6左右后水解。

减肥清脂 作用机制

丙酮酸钙进入体内会被胃液中的盐酸转化为弱性有机酸——丙酮酸，易于通过细胞膜到达线粒体。在此过程中它会将长链脂肪酸氧化燃烧以供能，从而导致宏观层面的脂肪减少和体重减轻。据美国匹兹堡大学医学研究中心研究结果显示，服用丙酮酸钙可增加至少48%的脂肪消耗。

临床效果

在六周时间内摄取一定量丙酮酸钙后测量的心率、血压及心率/血压分别降低了9%、6%和12%，同时血浆中的胆固醇与低密度脂蛋白水平也有所下降，分别为-4%和-5%。研究证实了丙酮酸钙在减肥消脂方面显著的效果。

服用副作用

适量服用丙酮酸钙通常不会对人体产生不良影响。然而一次性过量摄入可能会引起腹鸣、胃肠胀气或恶心等症状。因此，在使用过程中应注意遵循推荐剂量，避免不必要的健康风险。