A simple and efficient procedure for the synthesis of 2-hydroxy-2-(5-hydroxy-1H-pyrazol-4-yl)-2H-indene-1,3-dione derivatives, proceeding via aldol condensation between ninhydrin and various 3-alkyl-1H-pyrazol-5-ols is described. The syntheses were carried out in ethanol at room temperature and proceeded with short reaction times to give the products with high yields.
一种简单有效的合成 2-羟基-2-(5-羟基-1H-
吡唑-4-基)-2H-
茚-1,3-二酮衍
生物的方法,通过
茚三酮和各种 3-描述了烷基-1H-
吡唑-5-醇。合成在室温下在
乙醇中进行,反应时间短,产物收率高。