2',5'-bis(azidomethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid | 1073133-01-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2',5'-bis(azidomethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid
• 英文别名: 2',5'-Bis(azidomethyl)-4'-(4-carboxyphenyl)-[1,1'-biphenyl]-4-carboxylicacid；4-[2,5-bis(azidomethyl)-4-(4-carboxyphenyl)phenyl]benzoic acid
• CAS: 1073133-01-3
• 化学式: C₂₂H₁₆N₆O₄
• 分子量: 428.407
• InChiKey: VYPZGHXEPUXQIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2',5'-bis(azidomethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid 、 氯化锆(IV) 在 苯甲酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Pore Surface Engineering with Controlled Loadings of Functional Groups via Click Chemistry in Highly Stable Metal–Organic Frameworks

  摘要：

  Reactions of ZrCl4 and single or mixed linear dicarboxylic acids bearing methyl or aside groups lead to highly stable isoreticular metal-organic frameworks (MOFs) with content-tunable, accessible, reactive aside groups inside the large pores. These Zr-based MOFs offer an ideal platform for pore surface engineering by anchoring various functional groups with controlled loadings onto the pore walls via the click reaction, endowing the MOFs with tailor-made interfaces. Significantly, the framework and crystallinity of the functionalized MOFs are well-retained, and the engineered pore surfaces have been demonstrated to be readily accessible, thus providing more opportunities for powerful and broad applications of MOFs.

  DOI：

  10.1021/ja3063919
• 作为产物：
  描述：

  对苯二甲醇 在 吡啶 、 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 sodium azide 、 硫酸 、 碘 、 三溴化磷 、 碘酸 、 对甲苯磺酸 、 溶剂黄146 、 cesium fluoride 、 potassium hydroxide 、 sodium hydroxide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 四氯化碳 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 2',5'-bis(azidomethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid
  参考文献：
  名称：

  金属有机骨架中固定单体和移动单体之间的逐步增长共聚

  摘要：

  证明了固定在结晶态的单体与在溶液状态下可移动的单体之间的A–A / B–B逐步生长共聚。两种单体之一固定为金属-有机骨架（MOF）的有机配体，并与可移动的客体单体聚合，从而形成线性聚合物。聚合行为与溶液聚合完全不同。特别地，取决于MOF结构，聚合度（DP）收敛至特定值。不可避免的终止不是由于聚合反应的不完全，而是由于在几种相邻的固定单体中选择了两种聚合配偶体。基于聚合机理的蒙特卡洛模拟完全支持了这一点。

  DOI：

  10.1002/anie.201901308

文献信息

• Diverse Multi-Functionalized Oligoarenes and Heteroarenes for Porous Crystalline Materials
  作者：Sylvain Grosjean、Zahid Hassan、Christof Wöll、Stefan Bräse

  DOI：10.1002/ejoc.201801232

  日期：2019.2.21

  an advantageous dual‐utility. First, these compounds can serve as useful molecular bricks (ditopic organic linkers) in the construction of complex porous crystalline materials. Second, after the assembly into the crystalline coordination networks, orthogonal functional sites within the linker‐backbone offer tremendous potential from application perspectives as they can be modified by a wide range of

  描述了通过逐步钯催化硼酸化/Suzuki-Miyaura 交叉偶联反应模块化合成多功能联苯、三联苯和更高级的线性低聚苯二甲酸和吡啶封端的低聚芳烃。几个不同的官能团如叠氮化物、羟基和炔烃，以及在战略位置结合在单个低聚芳烃分子单元中的配位官能端基团（羧酸或吡啶）的存在提供了有利的双重用途。首先，这些化合物可以在复杂多孔晶体材料的构建中用作有用的分子砖（双位有机连接体）。其次，组装成晶体配位网络后，连接子骨架内的正交功能位点从应用角度提供了巨大的潜力，因为它们可以通过广泛的合成后修饰进行修饰，包括叠氮化物-炔烃点击化学。这允许进一步定制超分子组件以产生新型多功能材料。
• METAL-ORGANIC FRAMEWORK/STIMULUS-RESPONSIVE POLYMER COMPOSITE CAPABLE OF CONTROLLING RELEASE OF GUEST
  申请人：National University Corporation Hokkaido University

  公开号：EP3141263A1

  公开（公告）日：2017-03-15

  A metal-organic framework (MOF) having the function of controlling the release of guests is provided in which reversible release control is possible and release control can be rapidly performed and which is capable of accommodating the release of various guest molecules. The metal-organic framework comprises both an organic ligand having two or more functional groups (coordinating functional groups) capable of coordinating to a metal atom and metal ions that combine with the coordinating functional groups of the organic ligand, and has a structure in which one metal ion has combined with two or more of the coordinating functional groups to connect multiple molecules of the organic ligand. The metal-organic framework/stimulus-responsive polymer composite was obtained by affixing a stimulus-responsive polymer to at least some of the surface of the metal-organic framework. The stimulus-responsive polymer may be affixed by bonding to the organic ligand.

  本发明提供了一种具有控制客体释放功能的金属有机框架（MOF），该框架可实现可逆释放控制，并能快速进行释放控制，而且能够容纳各种客体分子的释放。金属有机框架包括具有两个或两个以上能与金属原子配位的官能团（配位官能团）的有机配体和与有机配体的配位官能团结合的金属离子，并具有一个金属离子与两个或两个以上配位官能团结合以连接多个有机配体分子的结构。金属有机框架/刺激响应型聚合物复合材料是通过将刺激响应型聚合物粘贴到金属有机框架的至少部分表面而获得的。刺激响应型聚合物可通过与有机配体键合来粘贴。
• “Clickable” Metal−Organic Framework
  作者：Yuta Goto、Hiroki Sato、Seiji Shinkai、Kazuki Sada

  DOI：10.1021/ja7114053

  日期：2008.11.5

  We demonstrated the metal-organic framework bearing the azide group in the organic linkers and in situ click reactions with some small alkynes. The XRPD patterns indicated that the click reaction proceeded without any decomposition of the original MOF network. Controlling the organic linkers and incorporation of the azide groups should provide the designer-made MOFs that have controlled molecular cavities with the desired steric dimensions and functionality.
• METAL-ORGANIC FRAMEWORK STIMULUS RESPONSIVE POLYMER COMPOSITE CAPABLE OF CONTROLLING RELEASE OF GUEST
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20170072070A1

  公开（公告）日：2017-03-16

  A metal-organic framework (MOF) having the function of controlling the release of guests is provided in which reversible release control is possible and release control can be rapidly performed and which is capable of accommodating the release of various guest molecules. The metal-organic framework comprises both an organic ligand having two or more functional groups (coordinating functional groups) capable of coordinating to a metal atom and metal ions that combine with the coordinating functional groups of the organic ligand, and has a structure in which one metal ion has combined with two or more of the coordinating functional groups to connect multiple molecules of the organic ligand. The metal-organic framework/Stimulus-responsive polymer composite was obtained by affixing a stimulus-responsive polymer to at least some of the surface of the metal-organic framework. The stimulus-responsive polymer may be affixed by bonding to the organic ligand.
• General and Direct Method for Preparing Oligonucleotide-Functionalized Metal-Organic Framework Nanoparticles
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20210236651A1

  公开（公告）日：2021-08-05

  The present disclosure generally relates to metal-organic framework nanoparticles containing terminal phosphate-modified oligonucleotides, methods for making the same, and methods of using the same.