1-n-pentylcyclohex-2-enol | 1291104-77-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-n-pentylcyclohex-2-enol
• 英文别名: 1-Pentylcyclohex-2-en-1-ol；1-pentylcyclohex-2-en-1-ol
• CAS: 1291104-77-2
• 化学式: C₁₁H₂₀O
• 分子量: 168.279
• InChiKey: YFKRTMFUNDPTPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-环己烯-1-酮 、 n-pentyl lithium 在 lithium bromide 、 氯化铵 作用下， 以 2-甲基四氢呋喃 、 正庚烷 、 水 为溶剂， 反应 2.0h， 以91%的产率得到1-n-pentylcyclohex-2-enol
  参考文献：
  名称：

  Highly regioselective control of 1,2-addition of organolithiums to α,β-unsaturated compounds promoted by lithium bromide in 2-methyltetrahydrofuran: a facile and eco-friendly access to allylic alcohols and amines

  摘要：

  Very high regioselective 1,2-addition of organolithiums to alpha,beta-unsaturated carbonyl-like compounds (ketones, aldehydes, and imines) in the presence of LiBr was achieved by carrying out reactions in the sustainable solvent 2-methyltetrahydrofuran. Excellent yields (in isolated product) of allylic alcohols and allylic amines were recovered under a simple experimental procedure at 0 degrees C. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.067

文献信息

• Highly regioselective control of 1,2-addition of organolithiums to α,β-unsaturated compounds promoted by lithium bromide in 2-methyltetrahydrofuran: a facile and eco-friendly access to allylic alcohols and amines
  作者：Vittorio Pace、Laura Castoldi、Pilar Hoyos、José Vicente Sinisterra、Massimo Pregnolato、José Ma Sánchez-Montero

  DOI：10.1016/j.tet.2011.01.067

  日期：2011.4

  Very high regioselective 1,2-addition of organolithiums to alpha,beta-unsaturated carbonyl-like compounds (ketones, aldehydes, and imines) in the presence of LiBr was achieved by carrying out reactions in the sustainable solvent 2-methyltetrahydrofuran. Excellent yields (in isolated product) of allylic alcohols and allylic amines were recovered under a simple experimental procedure at 0 degrees C. (C) 2011 Elsevier Ltd. All rights reserved.