环辛-5-烯-1,2-二醇 | 55519-21-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 环辛-5-烯-1,2-二醇
• 英文名称: 5-cyclooctene-1,2-diol
• 英文别名: cyclooct-5-ene-1,2-diol
• CAS: 55519-21-6；1018976-16-3；1018976-18-5；1104620-67-8
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: JWEYNDRAHPIRPI-UHFFFAOYSA-N

物化性质

• 沸点：
  233.5±40.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  环辛-5-烯-1,2-二醇 在 20% Ni/Al2O3 、 氢气 、 硫酸 、 双氧水 、 溶剂黄146 作用下， 95.0~180.0 ℃ 、200.0 kPa 条件下， 以93.8 %的产率得到辛二酸
  参考文献：
  名称：

  CN115304471

  摘要：

  公开号：
• 作为产物：
  描述：

  1,5-环辛二烯 在 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 以52%的产率得到环辛-5-烯-1,2-二醇
  参考文献：
  名称：

  Preparation of cubic-shaped sorafenib-loaded nanocomposite using well-defined poly(vinyl alcohol alt-propenylene) copolymer

  摘要：

  Vinyl alcohol (VA) copolymers having fine tunable polarities are emerging materials in drug delivery applications. VA copolymers rendering well-defined molecular architecture (C/OH ratio = 2, 4, 5 and 8) were used as carriers for model drug compound, fluorescein, which exhibited significantly different release characteristics depending on the polarity of the polymers. Based on the preliminary drug release tests the well-defined VA copolymer having C/OH = 5 ratio, poly(vinyl alcohol alt-propenylene) copolymer (PVA-5) was selected for nanocomposite synthesis. Sorafenib anticancer drug was embedded into PVA-5 (C/OH = 5 ratio) nanoparticles by nanoprecipitation resulting in nanoparticles exhibiting unusual cubic shape. The sorafenib-loaded nanocomposites showed continuous release during a day and concentration-dependant cytotoxicity on HT-29 cancer cells. This might be interpreted by the sustained release of the drug.

  DOI：

  10.1016/j.ijpharm.2019.03.008

文献信息

• Design and preparation of a polymer resin-supported organoselenium catalyst with industrial potential
  作者：Yuguang Wang、Lihua Yu、Bingchun Zhu、Lei Yu

  DOI：10.1039/c6ta02566h

  日期：——

  activated species that could be re-oxidized by air so that no excess H2O2 was required for the reaction. The results were superior to those of reactions catalyzed by small molecules, for which excess H2O2, long reaction time or expensive CF3-activated catalysts and environmentally unfriendly MeCN solvent were required.

  六价硒？是! 与小分子聚合物相比，聚合物上的硒具有完全不同的特性。在有机硒化学中稀有的六价硒被发现是聚合物中的主要物种。可回收的聚合物树脂上的高价硒元素可以快速催化环己烯与水中的H 2 O 2氧化反应，以几乎定量的产率生产工业上重要的中间体反式-1,2-环己二醇。在催化循环中，高价硒物种被还原为二价硒，这是一种高度活化的物种，可以被空气重新氧化，因此没有过量的H 2 O 2。反应所需的。结果优于由小分子催化的反应，需要过量的H 2 O 2，较长的反应时间或昂贵的CF 3活化催化剂以及对环境不利的MeCN溶剂。
• Highly active and green aminopropyl-immobilized phosphotungstic acid on mesocellular silica foam for the O-heterocyclization of cycloocta-1,5-diene with aqueous H2O2
  作者：Ruihua Gao、Quanjing Zhu、Wei-Lin Dai、Kangnian Fan

  DOI：10.1039/c0gc00691b

  日期：——

  The heteropoly phosphotungstic acid, H3PW12O40 (HPW), was successfully immobilized on the surface of MCF, SBA-15 and MCM-41 by means of chemical bonding to aminosilane groups. The as-obtained materials were characterized by N2 sorption, TEM, XRD, FT-IR, 13C-, 29Si-, 31P-MAS NMR and XPS. Characterization results suggest that the surface area decreased after grafting amino groups to silica. The as-prepared HPW-NH2-MCF is highly efficient in the O-heterocyclization of cycloocta-1,5-diene (COD) to 2,6-dihydroxy-9-oxabicyclo[3.3.1] nonane (1) and 2-hydroxy-9-oxabicyclo [3.3.1] nonane-6-one (2) with a COD conversion of 100% and (1 + 2) selectivity up to 98%. It is worth mentioning that this material could be reused six times without any significant loss of activity and selectivity. The good stability can be attributed to the strong interaction between the amino groups on the surface of MCF and HPW anions.

  通过化学键合氨基硅烷基团，异多聚磷钨酸（H3PW12O40，HPW）成功固定在MCF、SBA-15和MCM-41的表面。通过N2吸附、TEM、XRD、FT-IR、13C-、29Si-、31P-MAS NMR和XPS对所得材料进行表征。表征结果表明，在硅石上接枝氨基后，表面积减小。制备的HPW-NH2-MCF在环辛烷-1,5-二烯（COD）的O-杂环化反应中非常有效，可将COD转化为2,6-二羟基-9-氧杂双环[3.3.1]壬烷（1）和2-羟基-9-氧杂双环[3.3.1]壬烷-6-酮（2），COD转化率为100%，（1+2）选择性高达98%。值得一提的是，这种材料可以重复使用六次，而活性与选择性不会明显降低。这种良好的稳定性可归因于MCF表面氨基与HPW阴离子之间的强相互作用。