tert-butyl N-[2-[[bis(pyridin-2-ylmethyl)amino]methyl]-8-methoxy-4-(2-methylpropoxy)quinolin-7-yl]carbamate | 1173824-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: tert-butyl N-[2-[[bis(pyridin-2-ylmethyl)amino]methyl]-8-methoxy-4-(2-methylpropoxy)quinolin-7-yl]carbamate
• CAS: 1173824-16-2
• 化学式: C₃₂H₃₉N₅O₄
• 分子量: 557.693
• InChiKey: NKPCDWGFRUMRQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  41
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  98.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  tert-butyl 2-formyl-4-isobutoxy-8-methoxyquinolin-7-ylcarbamate 、 二甲基吡啶胺 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 tert-butyl N-[2-[[bis(pyridin-2-ylmethyl)amino]methyl]-8-methoxy-4-(2-methylpropoxy)quinolin-7-yl]carbamate
  参考文献：
  名称：

  Ratiometric Zn²⁺ Fluorescent Sensor and New Approach for Sensing Cd²⁺ by Ratiometric Displacement

  摘要：

  A fluorescent sensor QB, based on quinoline with DPA as receptor, is designed as a ratiometric sensor for Zn2+ and CHEF (chalation enhanced fluorescence) sensor for Cd2+. Moreover, another ratiometric signal output for Cd2+ can be observed when the bound Zn2+ in the QB-Zn2+ complex is displaced by Cd2+. These results demonstrate that OB can act not only as a ratiometirc sensor for Zn2+ but also as a dual-mode Cd2+-selective sensor via the CHEF mechanism and ratiometric displacement.

  DOI：

  10.1021/ol901380w

文献信息

• Ratiometric Zn²⁺ Fluorescent Sensor and New Approach for Sensing Cd²⁺ by Ratiometric Displacement
  作者：Lin Xue、Qing Liu、Hua Jiang

  DOI：10.1021/ol901380w

  日期：2009.8.6

  A fluorescent sensor QB, based on quinoline with DPA as receptor, is designed as a ratiometric sensor for Zn2+ and CHEF (chalation enhanced fluorescence) sensor for Cd2+. Moreover, another ratiometric signal output for Cd2+ can be observed when the bound Zn2+ in the QB-Zn2+ complex is displaced by Cd2+. These results demonstrate that OB can act not only as a ratiometirc sensor for Zn2+ but also as a dual-mode Cd2+-selective sensor via the CHEF mechanism and ratiometric displacement.