tert-butyl 2-formyl-4-isobutoxy-8-methoxyquinolin-7-ylcarbamate | 1173824-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: tert-butyl 2-formyl-4-isobutoxy-8-methoxyquinolin-7-ylcarbamate
• CAS: 1173824-21-9
• 化学式: C₂₀H₂₆N₂O₅
• 分子量: 374.437
• InChiKey: WZDJZRSWJQINTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  86.75
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-formyl-4-isobutoxy-8-methoxyquinolin-7-ylcarbamate 、 二甲基吡啶胺 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 tert-butyl N-[2-[[bis(pyridin-2-ylmethyl)amino]methyl]-8-methoxy-4-(2-methylpropoxy)quinolin-7-yl]carbamate
  参考文献：
  名称：

  Ratiometric Zn²⁺ Fluorescent Sensor and New Approach for Sensing Cd²⁺ by Ratiometric Displacement

  摘要：

  A fluorescent sensor QB, based on quinoline with DPA as receptor, is designed as a ratiometric sensor for Zn2+ and CHEF (chalation enhanced fluorescence) sensor for Cd2+. Moreover, another ratiometric signal output for Cd2+ can be observed when the bound Zn2+ in the QB-Zn2+ complex is displaced by Cd2+. These results demonstrate that OB can act not only as a ratiometirc sensor for Zn2+ but also as a dual-mode Cd2+-selective sensor via the CHEF mechanism and ratiometric displacement.

  DOI：

  10.1021/ol901380w
• 作为产物：
  描述：

  tert-butyl 2-(hydroxymethyl)-4-isobutoxy-8-methoxyquinolin-7-ylcarbamate 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以98%的产率得到tert-butyl 2-formyl-4-isobutoxy-8-methoxyquinolin-7-ylcarbamate
  参考文献：
  名称：

  Ratiometric Zn²⁺ Fluorescent Sensor and New Approach for Sensing Cd²⁺ by Ratiometric Displacement

  摘要：

  A fluorescent sensor QB, based on quinoline with DPA as receptor, is designed as a ratiometric sensor for Zn2+ and CHEF (chalation enhanced fluorescence) sensor for Cd2+. Moreover, another ratiometric signal output for Cd2+ can be observed when the bound Zn2+ in the QB-Zn2+ complex is displaced by Cd2+. These results demonstrate that OB can act not only as a ratiometirc sensor for Zn2+ but also as a dual-mode Cd2+-selective sensor via the CHEF mechanism and ratiometric displacement.

  DOI：

  10.1021/ol901380w