2-O-(2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl)-D-mannopyranose | 6917-17-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-O-(2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl)-D-mannopyranose
• 英文别名: 2-O-(2-O-α-D-mannopyranosyl-α-D-mannopyranosyl)-D-mannopyranose；Man-α-(1,2)-Man-α-(1,2)-Man；Man3；α-D-Manp-(1->2)-α-D-Manp-(1->2)-D-Man；alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-D-mannose；(3S,4S,5S,6R)-3-[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,4,5-triol
• CAS: 6917-17-5；15548-41-1；50271-59-5；50271-64-2；50906-47-3；77447-85-9；102046-34-4；111322-07-7；134931-19-4
• 化学式: C₁₈H₃₂O₁₆
• 分子量: 504.442
• InChiKey: UQBIAGWOJDEOMN-CCFXQEQMSA-N

物化性质

• 沸点：
  892.3±65.0 °C(Predicted)
• 密度：
  1.80±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  269
• 氢给体数：
  11
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  2,3,4,6-四-O-乙酰基-1-溴-Alpha-D-甘露糖 在 palladium on activated charcoal 氢气 、 sodium methylate 、 氰化汞 作用下， 以 甲醇 、 硝基甲烷 、 乙醇 、 溶剂黄146 、 苯 为溶剂， 反应 22.0h， 生成 2-O-(2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl)-D-mannopyranose
  参考文献：
  名称：

  Liptak; Imre; Nanasi, Carbohydrate research, 1983, vol. 114, # 1, p. 35 - 41

  摘要：

  DOI：

文献信息

• Enzymatic synthesis of mannobioses and mannotrioses by reverse hydrolysis using α-mannosidase from Aspergillus niger
  作者：Katsumi Ajisaka、Ichiro Matsuo、Megumi Isomura、Hiroshi Fujimoto、Mayumi Shirakabe、Mitsuyo Okawa

  DOI：10.1016/0008-6215(95)00015-l

  日期：1995.4

  including alpha-D-man-(1 --> 2)-D man and alpha-D-man-(1 --> 2)-alpha-D-man-(1 --> 2)-D-man were formed when a highly concentrated mannose solution was incubated in the presence of alpha-mannosidase from Aspergillus niger. alpha-D-Man-(1 --> 2)-D-man and alpha-D- man-(1 --> 2)-alpha-D-man-(1 --> 2)-D-man were isolated by activated carbon chromatography followed by high performance liquid chromatography

  各种甘露寡糖，包括alpha-D-man-（1-> 2）-D man和alpha-D-man-（1-> 2）-alpha-D-man-（1-> 2）-当在来自黑曲霉的α-甘露糖苷酶存在下孵育高度浓缩的甘露糖溶液时，形成D-man。alpha-D-Man-（1-> 2）-D-man和alpha-D-Man-（1-> 2）-alpha-D-man-（1-> 2）-D-man是通过活性炭色谱分离，然后使用氨基硅胶柱进行高效液相色谱分离。除上述寡糖外，α-D-人-（1-> 3）-D-人，α-D-人-（1-> 6）-D-人和α-D-人- （1-> 2）-alpha-D-man-（1-> 6）-D-man也被分离出来。
• Multivalent glyconanoparticles with enhanced affinity to the anti-viral lectin Cyanovirin-N
  作者：Xin Wang、Elena Matei、Lingquan Deng、Olof Ramström、Angela M. Gronenborn、Mingdi Yan

  DOI：10.1039/c1cc12981c

  日期：——

  Low-mannose (LM) structures were coupled to gold nanoparticles (Au NPs) to amplify the affinity of LMs with Cyanovirin-N (CV-N) lectins and to study the structures of CV-N variants CVNQ50C and CVNMutDB.

  将低甘露糖（LM）结构与金纳米粒子（Au NPs）耦合，以放大 LM 与 Cyanovirin-N (CV-N) 凝集素的亲和力，并研究 CV-N 变体 CVNQ50C 和 CVNMutDB 的结构。
• Sonication-Assisted Oligomannoside Synthesis
  作者：Christabel T. Tanifum、Cheng-Wei T. Chang

  DOI：10.1021/jo8019835

  日期：2009.1.16

  We have investigated the use of sonication for the synthesis of oligomannosides. A convenient sonication-mediated glycosylation protocol that is applicable to traditional glycosylation methods has been developed. This protocol can be applicable for activating glycosyl donors that are known to have low reactivity which enable the synthesis of oligomannosides of particular biological interest with the same efficiency.