1,8-diaminooxy-3,6-dioxaoctane | 98627-71-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,8-diaminooxy-3,6-dioxaoctane
• 英文别名: bis-aminooxy-PEG2,；bis-aminooxy-PEG2；1-(aminooxy)-2-{2-[2-(aminooxy)ethoxy]ethoxy}ethane；O-[2-[2-(2-aminooxyethoxy)ethoxy]ethyl]hydroxylamine
• CAS: 98627-71-5
• 化学式: C₆H₁₆N₂O₄
• 分子量: 180.204
• InChiKey: FDBZGQLBKGNQFT-UHFFFAOYSA-N

物化性质

• 沸点：
  339.7±32.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)
• 溶解度：
  溶于水、DMSO、DMF

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,8-diaminooxy-3,6-dioxaoctane 在 次氯酸叔丁酯 、 三乙胺 作用下， 以 氯仿 、 乙腈 为溶剂， 反应 6.58h， 生成 1,8-di(N-chloro-N',N'-dimethylcarbamoylaminooxy)-3,6-dioxaoctane
  参考文献：
  名称：

  Shtamburg, V. G.; Dmitrenko, A. A.; Pleshkova, A. P., Russian Journal of Organic Chemistry, 1993, vol. 29, # 9.1, p. 1464 - 1470

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-双(2-溴乙氧基)乙烷 在 一水合肼 、 三乙胺 作用下， 以 丙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 723.5h， 生成 1,8-diaminooxy-3,6-dioxaoctane
  参考文献：
  名称：

  Shtamburg, V. G.; Dmitrenko, A. A.; Pleshkova, A. P., Russian Journal of Organic Chemistry, 1993, vol. 29, # 9.1, p. 1464 - 1470

  摘要：

  DOI：

文献信息

• [EN] VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES<br/>[FR] ANTICORPS FONCTIONNALISÉS BILATÉRALEMENT PAR CYCLOADDITION
  申请人：SYNAFFIX BV

  公开号：WO2021144314A1

  公开（公告）日：2021-07-22

  The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate is according to structure (1): formula (1), wherein: - a, b, c and d are each independently 0 or 1; - e is an integer in the range of 0 - 10; - L1, L2 and L3 are linkers; - D is a payload; - BM is a branching moiety; - Su is a monosaccharide; - G is a monosaccharide moiety; - GlcNAc is an N-acetylglucosamine moiety; - Fuc is a fucose moiety; - Z are connecting groups. The invention further provides a method for preparing the antibody-payload conjugate according to the invention, an intermediate compound in that preparation method, and medical uses of the antibody-payload conjugate according to the invention.

  本发明提供了一种抗体-有效载荷偶联物，其有效载荷与抗体的比例为1。所述抗体-有效载荷偶联物如结构(1)所示：公式(1)，其中：- a、b、c和d每个独立地为0或1；- e是0至10之间的整数；- L1、L2和L3是连接臂；- D是有效载荷；- BM是分支基团；- Su是单糖；- G是单糖基团；- GlcNAc是N-乙酰葡萄糖胺基团；- Fuc是岩藻糖基团；- Z是连接基团。本发明还提供了根据本发明制备抗体-有效载荷偶联物的方法、该制备方法中的中间化合物，以及根据本发明的抗体-有效载荷偶联物的医疗用途。
• Growth Hormone Conjugate with Increased Stability
  申请人：Johansen Nils Langeland

  公开号：US20110263501A1

  公开（公告）日：2011-10-27

  Novel growth hormone conjugates comprising a growth hormone compound (GH) and a growth hormone binding protein (GHBP) are disclosed. The invention also encompasses a novel derivatization method for producing stable, long-lasting conjugate (hGH-GHBP) by site specific conjugation. The novel GH-GHBP conjugates have an extended half-life in circulation that facilitates therapeutic use of the protein. The GH-GHBP conjugates exhibit pharmacological properties such as increased functional in vivo half-life, improved renal filtration, improved protease protection and albumin binding.

  揭示了包括生长激素化合物（GH）和生长激素结合蛋白（GHBP）的新型生长激素共轭物。该发明还涵盖了一种用于通过位点特异性结合制备稳定、持久的共轭物（hGH-GHBP）的新型衍生化方法。新型GH-GHBP共轭物在循环中具有延长的半衰期，有助于蛋白质的治疗应用。GH-GHBP共轭物表现出诸如增加的体内功能半衰期、改善的肾脏过滤、改善的蛋白酶保护和结合白蛋白等药理特性。
• CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES
  申请人：Herrmann Andreas

  公开号：US20100226875A1

  公开（公告）日：2010-09-09

  The present invention relates to a dynamic mixture in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one O-substituted hydroxylamine or S-substituted thiohydroxylamine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide or fungicide aldehyde or ketone. This mixture is capable of releasing in a controlled and prolonged manner the aldehyde or ketone into the surrounding environment. Furthermore, the present invention concerns also the use of these dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles that include these mixtures.

  本发明涉及一种动态混合物，其为通过在水的存在下将至少一种O-取代羟胺或S-取代硫羟胺衍生物与至少一种香料、调味剂、驱虫剂或诱引剂、杀菌剂或杀真菌剂醛或酮反应而得到的动态混合物。该混合物能够以受控和延长的方式释放醛或酮进入周围环境。此外，本发明还涉及将这些动态混合物用作调香成分以及包括这些混合物的调香组合物或香气物品的用途。
• Valency platform molecules comprising aminooxy groups
  申请人：——

  公开号：US20040224366A1

  公开（公告）日：2004-11-11

  Molecules comprising aminooxy groups are provided, wherein the aminooxy groups provide attachment sites for the covalent attachment of other molecules. In one embodiment, polyoxyethylene molecules comprising aminooxy groups are provided that can be conjugated to wide variety of biologically active molecules including poly(amino acids). In another embodiment, valency platform molecules comprising aminooxy groups are provided. The aminooxy groups can be used to form covalent bonds with biological molecules such as poly(amino acids). The aminooxy groups can, for example, react with poly(amino acids) modified to contain carbonyl groups, such as glyoxyl groups, to form a conjugate of the valency platform molecule and the biologically active molecule via an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in the formation of conjugates, and they also can be readily synthesized to form a composition with very low polydispersity.

  提供了含有氨氧基团的分子，其中氨氧基团提供了其他分子的共价连接点。在一个实施例中，提供了含有氨氧基团的聚氧乙烯分子，可以与包括聚（氨基酸）在内的各种生物活性分子结合。在另一个实施例中，提供了含有氨氧基团的价平台分子。氨氧基团可以用于与生物分子（如聚（氨基酸））形成共价键。例如，氨氧基团可以与改性为含有羰基基团（如乙酰甘氨酸基团）的聚（氨基酸）反应，通过肟键形成价平台分子和生物活性分子的结合物。含有氨氧基团的价平台分子在形成结合物时具有优异的反应性，而且它们也可以容易地合成成具有非常低的多分散性的组合物。
• Therapeutic and diagnostic domain 1 beta2GP1 polypeptides and methods of using same
  申请人：Marquis M. David

  公开号：US20050004351A1

  公开（公告）日：2005-01-06

  The present invention provides domain 1 β 2 GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 β 2 GPI polypeptides and mimetics. Domain 1 of β 2 GPI has been shown to bind to anti-cardiolipin (β 2 GPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 β 2 GPI polypeptides may be used to detect β 2 GPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 β 2 GPI polypeptides.

  本发明提供了1区β2GPI多肽、编码这些多肽的多核苷酸、这些多肽的类似物以及使用1区β2GPI多肽和类似物的方法。已经证明β2GPI的1区能够结合抗心磷脂（β2GPI依赖性抗磷脂抗体），这些抗体与多种病理学如血栓形成和胎儿流产有关。1区β2GPI多肽可用于检测样品中的β2GPI依赖性抗磷脂抗体。本发明还提供了使用这些1区β2GPI多肽诱导耐受的方法。