Methyl 2-[(2-formylphenoxy)methyl]benzoate | 1209456-75-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-[(2-formylphenoxy)methyl]benzoate
• 英文别名: methyl 2-[(2-formylphenoxy)methyl]benzoate
• CAS: 1209456-75-6
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: FLJMUKHPLYLCCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 2-[(2-formylphenoxy)methyl]benzoate 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 以90%的产率得到2-[(2-formylphenoxy)methyl]benzoic acid
  参考文献：
  名称：

  A convenient synthesis of heterocyclic compounds containing 11-oxo-6,11,12,13-tetrahydrodibenzo[b,g][1,5]oxazonine fragment

  摘要：

  A convenient synthesis of rare diaryl-fused nine-membered heterocyclic scaffold using a novel modification of four-component Ugi condensation based on the usage of aromatic aldehyde-acid as bifunctional component is described.

  DOI：

  10.1016/j.mencom.2009.09.020
• 作为产物：
  描述：

  2-溴甲基苯甲酸甲酯 、 水杨醛 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以75%的产率得到Methyl 2-[(2-formylphenoxy)methyl]benzoate
  参考文献：
  名称：

  A convenient synthesis of heterocyclic compounds containing 11-oxo-6,11,12,13-tetrahydrodibenzo[b,g][1,5]oxazonine fragment

  摘要：

  A convenient synthesis of rare diaryl-fused nine-membered heterocyclic scaffold using a novel modification of four-component Ugi condensation based on the usage of aromatic aldehyde-acid as bifunctional component is described.

  DOI：

  10.1016/j.mencom.2009.09.020

文献信息

• Small Molecule Inhibitors of Ebola and Lassa Fever Viruses
  申请人：Cunningham James

  公开号：US20140329834A1

  公开（公告）日：2014-11-06

  The present invention relates to compositions and methods for the treatment of infection by enveloped viruses, such as Ebola and Lassa fever viruses.

  本发明涉及用于治疗被包膜病毒感染，如埃博拉和拉沙热病毒的组合物和方法。
• US9452992B2
  申请人：——

  公开号：US9452992B2

  公开（公告）日：2016-09-27
• [EN] SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DES VIRUS ÉBOLA ET DE LA FIÈVRE DE LASSA
  申请人：HARVARD COLLEGE

  公开号：WO2013022550A2

  公开（公告）日：2013-02-14

  The present invention relates to compositions and methods for the treatment of infection by enveloped viruses, such as Ebola and Lassa fever viruses.
• A convenient synthesis of heterocyclic compounds containing 11-oxo-6,11,12,13-tetrahydrodibenzo[b,g][1,5]oxazonine fragment
  作者：Victor V. Potapov、Nataliya A. Fetisova、Alexandr V. Nikitina、Alexandre V. Ivachtchenko

  DOI：10.1016/j.mencom.2009.09.020

  日期：2009.9

  A convenient synthesis of rare diaryl-fused nine-membered heterocyclic scaffold using a novel modification of four-component Ugi condensation based on the usage of aromatic aldehyde-acid as bifunctional component is described.