2-Amino-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile | 609343-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Amino-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile
• 英文别名: 2-Amino-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile；2-amino-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile
• CAS: 609343-61-5
• 化学式: C₁₄H₁₅N₃O₃
• 分子量: 273.291
• InChiKey: YCZMGUJSMYLTQK-UHFFFAOYSA-N

物化性质

• 沸点：
  479.0±45.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,4-二氯-5-甲氧基苯胺 、 N,N-二甲基甲酰胺二甲基缩醛 、 2-Amino-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile 在 溶剂黄146 作用下， 生成 (2,4-Dichloro-5-methoxy-phenyl)-[7-methoxy-8-(2-methoxy-ethoxy)-pyrimido[4,5-b]quinolin-4-yl]-amine
  参考文献：
  名称：

  Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines

  摘要：

  4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b] quinolines are much less effective Src inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00628-0
• 作为产物：
  描述：

  3-methoxy-4-(2-methoxyethoxy)benzaldehyde 在 硝酸 、 β-丙氨酸 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 生成 2-Amino-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile
  参考文献：
  名称：

  Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines

  摘要：

  4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b] quinolines are much less effective Src inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00628-0

文献信息

• Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines
  作者：Diane H. Boschelli、Dennis Powell、Jennifer M. Golas、Frank Boschelli

  DOI：10.1016/s0960-894x(03)00628-0

  日期：2003.9

  4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b] quinolines are much less effective Src inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.