2-溴乙胺盐酸盐 | 58861-74-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 中文名称: 2-溴乙胺盐酸盐
• 英文名称: 2-bromoethylamine hydrochloride
• 英文别名: 2-bromoethanamine hydrochloride；2-bromoethan-1-amine hydrochloride；2-bromoethanamine;hydrochloride
• CAS: 58861-74-8
• 化学式: C₂H₆BrN*ClH
• 分子量: 160.441
• InChiKey: OLYBTQCLJOBELT-UHFFFAOYSA-N

物化性质

• 熔点：
  168-170 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-溴乙胺盐酸盐 在 disodium telluride 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.0h， 以70%的产率得到bis(2-aminoethyl)telluride
  参考文献：
  名称：

  A facile access to chalcogen and dichalcogen bearing dialkylamines and diols

  摘要：

  A highly practical procedure for the preparation of novel classes of chalcogen bearing diamines [{H2N(CH2)n}E] and diols [{HO(CH2)n}(2)E] (n = 2 or 3 and E = Se or Te) by the reaction of disodiumchalcogenide and haloalkylamines or haloalcohols is presented. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.12.035
• 作为产物：
  描述：

  2-溴乙酰胺 在 [(η⁶-p-cymene){(IMes)P}RuCl] 、 频那醇硼烷 、 盐酸 作用下， 以 水 为溶剂， 反应 26.0h， 以69%的产率得到2-溴乙胺盐酸盐
  参考文献：
  名称：

  N-杂环卡宾-膦基配合物作为硼氢化催化剂

  摘要：

  N-杂环卡宾-膦基加合物 (NHC)PSiMe 3和 (NHC)PH 与双核钌和锇配合物 [(η 6 - p -cymene)MCl 2 ] 2 (M = Ru, Os) 的反应得到半夹心配合物[(η 6 - p -伞花烃){(NHC)P}MCl]和[(η 6 - p -伞花烃){(NHC)PH}MCl 2] 分别具有两腿和三腿钢琴凳几何形状（NHC = IDipp，IMes；IDipp = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene；IMes = 1,3-bis(2 ,4,6-三甲基苯基）咪唑啉-2-亚基）。该配合物最初作为苯甲腈硼氢化的预催化剂进行了测试，最活跃的物种，钌配合物 [(η 6 - p -cymene){(IMes)P}RuCl]，被进一步用于广泛的硼氢化反应。在相对温和的反应条件（60–80 °C，3–5 mol%

  DOI：

  10.1021/acs.joc.1c02377

文献信息

• BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1422228A1

  公开（公告）日：2004-05-26

  The present invention provides a novel benzazepine derivative represented by formula : wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula -W1-X2-W2- (W1 and W2 are independently S(O)m1 (m1 is 0, 1 or 2), etc., and X2 is an optionally substituted alkylene groupetc. ), a preparation method and use thereof.

  本发明提供了一种新型的苯并氮杂环衍生物，其由以下公式表示： 其中，R1是一个5-或6-成员的芳香环，R2是低级烷基团等，Y是可选地取代的亚氨基，环A和环B是独立地选自一个可选地取代的芳香环，W是公式-W1-X2-W2-（W1和W2是独立地为S(O)m1（m1是0、1或2）等，X2是一个可选地取代的亚烷基团等），其制备方法及其用途。
• Synthesis of 5-methyl-4-oxo-quinolinecarboxylic acids
  作者：Susan E. Hagen、John M. Domagala

  DOI：10.1002/jhet.5570270616

  日期：1990.9

  A series of 5-methyl-4-oxo-3-quinolinecarboxylic acids was prepared in which the eight-position was substituted with fluorine, chlorine, methyl, or hydrogen. These quinolones were synthesized from the appropriate 2-methyl-3,4,6-trifluorobenzoic acids which were derived from oxazolines 8 and 16. The oxazoline moiety served as both an ortho-director (where feasible) and a protecting group; a trimethylsilyl

  制备了一系列5-甲基-4-氧代-3-喹啉羧酸，其中八个位置被氟，氯，甲基或氢取代。这些喹诺酮是由衍生自恶唑啉8和16的合适的2-甲基-3,4,6-三氟苯甲酸合成的。恶唑啉部分既是邻位导向基团（在可行的情况下）又是保护基团；三甲基甲硅烷基部分被用来封闭分子中最酸性的位点。
• [EN] OXAZOLE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS OXAZOLE ANTAGONISTES DES RÉCEPTEURS D'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2015018029A1

  公开（公告）日：2015-02-12

  The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及氧唑化合物，其为促进睡眠的受体拮抗剂。本发明还涉及所述氧唑化合物在潜在治疗或预防涉及促进睡眠的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及促进睡眠的疾病中的用途。
• [EN] OXAZOLE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR D'OREXINE À BASE D'OXAZOLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2015020930A1

  公开（公告）日：2015-02-12

  The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及氧唑化合物，其为促进素受体的拮抗剂。本发明还涉及所述氧唑化合物在潜在的治疗或预防涉及促进素受体的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及促进素受体的疾病中的用途。
• Discovery of small molecule antagonists of TRPV1
  作者：Harshad K Rami、Mervyn Thompson、Paul Wyman、Jeffrey C Jerman、Julie Egerton、Stephen Brough、Alexander J Stevens、Andrew D Randall、Darren Smart、Martin J Gunthorpe、John B Davis

  DOI：10.1016/j.bmcl.2004.05.028

  日期：2004.7

  Small molecule antagonists of the vanilloid receptor 1 (TRPV1, also known as VR1) are disclosed. Ureas such as 5 (SB-452533) were used to explore the structure activity relationship with several potent analogues identified. Pharmacological studies using electrophysiological and FLIPR Ca(2+) based assays showed compound 5 was an antagonist versus capsaicin, noxious heat and acid mediated activation

  公开了类香草素受体1（TRPV1，也称为VR1）的小分子拮抗剂。使用尿素（例如5（SB-452533））探索与几种确定的有效类似物的结构活性关系。使用基于电生理和FLIPR Ca（2+）的分析的药理研究表明，化合物5是辣椒素，有毒热量和酸介导的TRPV1活化剂的拮抗剂。对5的季盐的研究支持了一种作用方式，其中该系列化合物通过TRPV1受体上的细胞外可及结合位点引起抑制作用。