2-溴水杨酸 | 1321-05-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-溴水杨酸
• 中文别名: 2-溴代水杨酸
• 英文名称: 2-Bromosalicylic acid
• 英文别名: 6-bromo-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid
• CAS: 1321-05-7
• 化学式: C₇H₇BrO₃
• 分子量: 219.03
• InChiKey: IWJWHLRGMLXGPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] COMPOSÉS INÉDITS
  申请人：GLAXO GROUP LTD

  公开号：WO2011038572A1

  公开（公告）日：2011-04-07

  The present invention discloses novel compounds inhibiting LRRK2 kinase activity, the preparation processes thereof, the compositions containing them, as well as the use in treating diseases characterized by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease.

  本发明公开了抑制LRRK2激酶活性的新化合物，其制备过程，含有它们的组合物，以及在治疗以LRRK2激酶活性为特征的疾病中的应用，特别是帕金森病和阿尔茨海默病。
• THROMBOPOIETIN MIMETICS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1294378A2

  公开（公告）日：2003-03-26
• EP1294378A4
  申请人：——

  公开号：EP1294378A4

  公开（公告）日：2004-01-28
• NOVEL COMPOUNDS
  申请人：Glaxo Group Limited

  公开号：EP2483254A1

  公开（公告）日：2012-08-08
• NICOTINE SALTS, CO-CRYSTALS, AND SALT CO-CRYSTAL COMPLEXES
  申请人：R.J. Reynolds Tobacco Company

  公开号：US20160185750A1

  公开（公告）日：2016-06-30

  The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.