生育三稀酚 | 6829-55-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 生育三稀酚
• 英文名称: Alpha tocotrienol
• 英文别名: 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol
• CAS: 6829-55-6
• 化学式: C₂₆H₃₈O₂
• 分子量: 382.6
• InChiKey: GJJVAFUKOBZPCB-UHFFFAOYSA-N

物化性质

• 沸点：
  507.5±39.0 °C(Predicted)
• 密度：
  0.973±0.06 g/cm3(Predicted)
• LogP：
  9.380 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Silicon-based tocopherol derivatives
  申请人：Arkles C. Barry

  公开号：US20070253925A1

  公开（公告）日：2007-11-01

  Silicon-based tocopherol derivatives are provided, as well as methods for making the same, in which the derivatives have a tocopherol molecule having a silicon-based group. The derivatives are useful in cosmetic compositions, have antioxidant properties, enhance solubility and compatibility in cosmetic formulations having silicon-based materials within the compositions.

  提供了基于硅的生育酚衍生物，以及制备这些衍生物的方法，其中衍生物具有具有基于硅的基团的生育酚分子。这些衍生物在化妆品配方中很有用，具有抗氧化性能，在含有基于硅的材料的化妆品配方中增强了溶解性和相容性。
• Pharmaceutical composition and dosage forms for administration of hydrophobic drugs
  申请人：Lipocine, Inc.

  公开号：EP2246049A2

  公开（公告）日：2010-11-03

  Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, preferably a vitamin E substance; and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.

  提供了用于服用疏水性药物，特别是类固醇的药物组合物和剂型。这些药物组合物包括治疗有效量的疏水性药物，最好是类固醇；增溶剂，最好是维生素 E 物质；以及表面活性剂。疏水性药物和维生素 E 物质之间的协同作用使药物制剂中活性剂和增溶剂的分散性得到改善。由于分散性得到改善，药物组合物在服用时的生物利用度也得到了提高。此外，还提供了改善病人服用疏水性药物生物利用度的方法。
• Methods for preparing botanical extracts
  申请人：Signum Biosciences, Inc.

  公开号：US10912812B2

  公开（公告）日：2021-02-09

  Method of preparing a botanical extract that includes contacting a raw botanical with a solvent having a dielectric constant ranging from about 2.3 to about 25 and allowing the mixture to reside for a sufficient time to obtain a crude extract; filtering out remaining raw botanical and evaporating the solvent from the crude extract under reduced pressure to obtain a dried crude extract; washing the dried crude extract with a polar solvent having a dielectric constant of no less than 30, heating the resulting mixture, and allowing to cool to ambient; collecting a filtrate from the above cooled mixture; washing the collected filtrate with a non-polar solvent having a dielectric constant of no more than 2.0; and filtering and drying the mixture to obtain the botanical extract.

  制备植物提取物的方法，包括将植物原料与介电常数介于约2.3至约25的溶剂接触，并使混合物停留足够的时间，以获得粗提取物；过滤掉剩余的植物原料，并在减压下蒸发粗提取物中的溶剂，以获得干燥的粗提取物；用介电常数不小于30的极性溶剂洗涤干燥的粗提取物，加热所得混合物，并使其冷却至环境温度；从上述冷却的混合物中收集滤液；用介电常数不大于2.0的非极性溶剂洗涤收集的滤液；过滤并干燥混合物，以获得植物提取物。0 的非极性溶剂洗涤；过滤并干燥混合物，得到植物提取物。
• Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
  申请人：——

  公开号：US20030236236A1

  公开（公告）日：2003-12-25

  Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, preferably a vitamin E substance; and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharamaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.

  提供了用于服用疏水性药物，特别是类固醇的药物组合物和剂型。这些药物组合物包括治疗有效量的疏水性药物，最好是类固醇；增溶剂，最好是维生素 E 物质；以及表面活性剂。疏水性药物和维生素 E 物质之间的协同作用使药物制剂中活性剂和增溶剂的分散性得到改善。由于分散性得到改善，药物组合物在服用时的生物利用度也得到了提高。此外，还提供了提高病人服用疏水性药物生物利用度的方法。
• Compositions and methods for enhancing cognitive function
  申请人：Stock B. Jeffry

  公开号：US20060171938A1

  公开（公告）日：2006-08-03

  The invention encompasses novel compositions containing a methylation modifying compound isolated from botanical raw materials, including a fruit of the genus Coffea , and microbial raw materials, methods of making such compositions, and methods of treating or preventing human disease using such compositions. The methylation modifying compound in botanical extracts of the present invention can dramatically increase the level of methylation of PP2A, thus increasing cognitive function, particularly in persons suffering from or prone to developing Alzheimer's disease.

  本发明包含新型组合物，其中含有一种从植物原料中分离出来的甲基化修饰化合物，植物原料包括 咖啡 和微生物原料中分离出来的一种甲基化修饰化合物的新型组合物、制造这种组合物的方法以及使用这种组合物治疗或预防人类疾病的方法。本发明植物提取物中的甲基化修饰化合物可显著提高 PP2A 的甲基化水平，从而增强认知功能，尤其是对患有或易患阿尔茨海默氏症的人。