2-甲氧基-4-吡啶醇 | 66080-45-3

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-甲氧基-4-吡啶醇
• 中文别名: 2-甲氧基-4-羟基吡啶；2-甲氧基吡啶-4-醇
• 英文名称: 2-methoxypyridin-4-ol
• 英文别名: 2-methoxy-1H-pyridin-4-one
• CAS: 66080-45-3
• 化学式: C₆H₇NO₂
• 分子量: 125.127
• InChiKey: LRNDOTVCAIEGPH-UHFFFAOYSA-N

物化性质

• 密度：
  1.190

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Methoxy-4-pyridinol
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Methoxy-4-pyridinol
CAS number: 66080-45-3

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H7NO2
Molecular weight: 125.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-甲氧基-4-吡啶醇 在 锰 、 bis(triphenylphosphine)nickel(II) chloride 、 硫酰氟 、 新铜试剂 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 44.0h， 生成 2-甲氧基异烟酸甲酯
  参考文献：
  名称：

  使用二氧化碳的镍催化芳基和杂芳基氟代硫酸盐的羧化反应

  摘要：

  利用CO 2作为C1合成子来构建羧酸的有效且实用的方法的开发非常重要。描述了用CO 2进行镍催化的芳基氟代硫酸盐和杂芳基氟代硫酸盐的羧化，在温和条件下提供芳烃羧酸，具有良好的产率或优异的产率。另外，开发了一种单锅酚氟代硫酸化/羧化。

  DOI：

  10.1021/acs.orglett.9b00836
• 作为产物：
  描述：

  4-苄氧基-2(1H)-吡啶酮 在 palladium 10% on activated carbon 、 氢气 、 silver carbonate 作用下， 以 乙醇 、 氯仿 为溶剂， 30.0~40.0 ℃ 、206.85 kPa 条件下， 反应 15.0h， 生成 2-甲氧基-4-吡啶醇
  参考文献：
  名称：

  MODIFIED COMPOUND OF ANDROGRAPHOLIDE

  摘要：

  本公开披露了穿心莲内酯的修改化合物，特别是公开了公式(I)和(II)所示的化合物或其药用可接受的盐。

  公开号：

  US20180346438A1

文献信息

• [EN] LINEAR GLYCOSIDASE INHIBITORS<br/>[FR] INHIBITEURS LINÉAIRES DE LA GLYCOSIDASE
  申请人：ASCENEURON S A

  公开号：WO2019037860A1

  公开（公告）日：2019-02-28

  Compounds of formula (I) wherein A, R, W, Q, L, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

  式（I）中A、R、W、Q、L、n和m的含义如权利要求所述，可用于治疗tau病和阿尔茨海默病。
• 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE
  申请人：Horiuchi Yoshihiro

  公开号：US20120225876A1

  公开（公告）日：2012-09-06

  Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R 1a and R 1b may be the same or different and each independently represents a C 1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X 1 represents a hydroxyl group or an aminocarbonyl group; Z 1 represents a single bond or the like; and R 2 represents an optionally substituted C 1-6 alkyl group, an optionally substituted C 6-10 aryl group or the like.)

  公开了一种由公式(1)表示的化合物或其药理可接受的盐(在公式中，A代表由公式(A-1)表示的基团；R1a和R1b可以相同或不同，每个独立地表示一个可以由一个到三个卤素原子取代的C1-6烷基；m和n各自独立地表示0-5之间的整数；X1代表羟基或氨基甲酰基；Z1代表单键等；R2代表一个可选地取代的C1-6烷基，一个可选地取代的C6-10芳基等)。
• [EN] DIHYDROCYCLOPENTA-ISOQUINOLINE-SULFONAMIDE DERIVATIVES COMPOUNDS<br/>[FR] COMPOSÉS DÉRIVÉS DE DIHYDROCYCLOPENTA-ISOQUINOLINE-SULFONAMIDE
  申请人：UCB BIOPHARMA SRL

  公开号：WO2021130259A1

  公开（公告）日：2021-07-01

  The present invention relates to dihydrocyclopenta-isoquinoline-sulfonamide derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular disorders caused by the interaction of IgE with the FcεRI receptor.

  本发明涉及式(I)的二氢环戊基异喹啉磺胺衍生物，以及制备它们的方法、含有它们的药物组合物以及它们在治疗由IgE引起的疾病（如过敏反应、非过敏性肥大细胞反应或某些自身免疫反应）中的用途，特别是由IgE与FcεRI受体相互作用引起的疾病。
• Structure–Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930
  作者：Tsuyoshi Shinozuka、Tomoharu Tsukada、Kunihiko Fujii、Eri Tokumaru、Yumi Matsui、Satoko Wakimoto、Tsuneaki Ogata、Kazushi Araki、Ryoko Sawamura、Nobuaki Watanabe、Makoto Mori、Jun Tanaka

  DOI：10.1021/acsmedchemlett.8b00645

  日期：2019.3.14

  Derivatization efforts were continued to discover backups for a potent selective PPARγ modulator, DS-6930. In this Letter, the replacement of 2-pyridine ring in DS-6930 with 3- or 4-pyridyl group is reported. As the introduction of substituents on the pyridine ring did not provide potent partial agonists, modifications of benzimidazole ring were explored to discover potent intermediate agonists. 4′-Alkoxy

  继续进行衍生化工作，以发现有效的选择性PPARγ调节剂DS-6930的后备材料。在这封信中，报道了DS-6930中的2-吡啶环被3-或4-吡啶基取代。由于在吡啶环上引入取代基不提供有效的部分激动剂，因此对苯并咪唑环的修饰进行了探索以发现有效的中间激动剂。4'-烷氧基取代的苯并咪唑在体内没有显示出有效的功效，而7'-氟苯并咪唑3g（DS19161384）被发现可导致血浆葡萄糖大量降低，并具有出色的DMPK谱。
• Efficient Synthesis of N-Alkylated 4-Pyridones by Copper-Catalyzed Intermolecular Asymmetric Propargylic Amination
  作者：Wen Shao、Ye Wang、Ze-Peng Yang、Xiao Zhang、Shu-Li You

  DOI：10.1002/asia.201800373

  日期：2018.5.4

  Copper‐catalyzed intermolecular asymmetric propargylic amination with 4‐hydroxypyridines has been realized for the first time. In the presence of Cu complex derived from Pybox ligand, the N‐propargylated 4‐pyridones were obtained under mild reaction conditions with up to 99 % yield and 95 % ee. The Pybox ligand bearing a 4‐F‐phenyl substituent plays a key role for the high enantioselectivity. The products

  首次实现了铜催化的4-羟基吡啶分子间不对称炔丙基胺化反应。在存在源自Pybox配体的Cu络合物的情况下，在温和的反应条件下可获得N炔丙基化的4-吡啶酮，收率高达99％，ee高达95％。带有4-F-苯基取代基的Pybox配体对于高对映选择性起着关键作用。该产物可以容易地转化为喹oli嗪生物碱的核心结构。