2-羟基-1,2,3-丙烷三羧酸钾钠盐水合物 | 55049-48-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-羟基-1,2,3-丙烷三羧酸钾钠盐水合物
• 中文别名: 2-羟基-1,2,3-丙烷三羧酸钾钠盐水合物(5:6:6:?)
• 英文名称: Uralyt-U
• 英文别名: tripotassium;trisodium;2-hydroxypropane-1,2,3-tricarboxylate;hydrate
• CAS: 55049-48-4
• 化学式: C12H12K3Na3O15
• 分子量: 582.48
• InChiKey: IYKMDRMCUIFHRA-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  -29.31
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  282
• 氢给体数：
  3
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  2-羟基-1,2,3-丙烷三羧酸钾钠盐水合物 、 水 在 水 作用下， 以to give the title compound as a yellow solid (7.72 g, 82% yield)的产率得到葡萄糖
  参考文献：
  名称：

  Novel bisphosphonates and uses thereof

  摘要：

  糖苷和正酯基糖苷衍生物的双磷酸盐化合物可用于治疗和/或预防恶性高钙血症、佩吉特病、骨质疏松症、骨骼和软组织的转移性癌症以及牙周病，其具有明显增强的肠道吸收和生物利用度。

  公开号：

  US20020002140A1

文献信息

• Methods and compositions for inducing resistance to bacterial infections
  申请人：Stanley Drug Products, Inc.

  公开号：US03995051A1

  公开（公告）日：1976-11-30

  A variety of substances are reported which alter host resistance to cocci and bacilli bacterial infections. Nevertheless, because of the extreme difficulty of total eradication, and the frequent reappearance of the same strains, even after their apparently successful elimination, there is a continuing need for drugs for the treatment of coccic infections. Certain guanidinoacylhistidines are effective in inducing resistance to infections due to cocci and bacilli.

  报道了多种物质可以改变宿主对球菌和杆菌细菌感染的抵抗力。然而，由于完全消灭的极度困难以及即使在看似成功消除后，相同菌株的频繁重新出现，治疗球菌感染的药物仍然是必需的。某些鸟氨酰组氨酸可以有效地诱导对球菌和杆菌感染的抵抗力。
• Processes for preparing 2'-deoxy-2'-fluorocoformycin and stereoisomers
  申请人：Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

  公开号：US05773607A1

  公开（公告）日：1998-06-30

  2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin are synthesized in this invention through a multi-stage process via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.- and -.beta.-D-ribofuranosyl bromides. Further, according to this invention, 2'-deoxy-2'-epi-2'-fluorocoformycin and 2'-deoxy-8,2'-diepi-2'-fluorocoformycin are synthesized by a multi-stage process starting from 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.-D-arabinofuranosyl bromide. These four 2'-fluoro derivatives of coformycin are novel compounds and have high enzyme-inhibitory activities against adenosine deaminase. In particular, these novel compounds are useful substances which exhibit therapeutic effects on acute lymphocytic leukemias due to their high enzyme-inhibitory activities above-mentioned. In addition, a variety of intermediates are obtained as novel compounds which are useful for the synthesis of the aforesaid novel 2'-fluoro derivatives of coformycin.

  本发明通过经过多阶段的过程，通过3,5-二-O-苯甲酰基-2-脱氧-2-氟-.alpha.-和-.beta.-D-核糖溴化物合成了2'-脱氧-2'-氟可酶霉素和2'-脱氧-8-表-2'-氟可酶霉素。此外，根据本发明，从3,5-二-O-苯甲酰基-2-脱氧-2-氟-.alpha.-D-阿拉伯核糖溴化物开始，通过多阶段过程合成了2'-脱氧-2'-表-2'-氟可酶霉素和2'-脱氧-8,2'-双表-2'-氟可酶霉素。这四种2'-氟可酶霉素衍生物是新化合物，并且对腺苷脱氨酶具有高的酶抑制活性。特别是，这些新化合物是有用的物质，因为它们具有上述高酶抑制活性，对急性淋巴细胞白血病具有治疗作用。此外，还获得了多种中间体作为新化合物，这些中间体对于合成上述新的2'-氟可酶霉素衍生物是有用的。
• 2'-deoxy-2'-epi-2'-fluorocoformycin
  申请人：Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

  公开号：US05886167A1

  公开（公告）日：1999-03-23

  2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin are synthesized in this invention through a multi-stage process via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.- and -.beta.-D-ribofuranosyl bromides. Further, according to this invention, 2'-deoxy-2'-epi-2'-fluorocoformycin and 2'-deoxy-8,2'-diepi-2'-fluorocoformycin are synthesized by a multi-stage process starting from 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.-D-arabinofuranosyl bromide. These four 2'-fluoro derivatives of coformycin are novel compounds and have high enzyme-inhibitory activities against adenosine deaminase. In particular, these novel compounds are useful substances which exhibit therapeutic effects on acute lymphocytic leukemias due to their high enzyme-inhibitory activities above-mentioned. In addition, a variety of intermediates are obtained as novel compounds which are useful for the synthesis of the aforesaid novel 2'-fluoro derivatives of coformycin.

  本发明通过经过多阶段的过程，通过3,5-二-O-苯甲酰基-2-脱氧-2-氟-α-和β-D-核糖溴化物合成了2'-脱氧-2'-氟可酶霉素和2'-脱氧-8-表-2'-氟可酶霉素。此外，根据本发明，通过从3,5-二-O-苯甲酰基-2-脱氧-2-氟-α-D-阿拉伯核糖溴化物开始的多阶段过程，合成了2'-脱氧-2'-表-2'-氟可酶霉素和2'-脱氧-8,2'-二表-2'-氟可酶霉素。这四种2'-氟可酶霉素衍生物是新化合物，并且对腺苷脱氨酶具有高酶抑制活性。特别是，由于其上述高酶抑制活性，这些新化合物是具有治疗急性淋巴细胞白血病的有用物质。此外，还获得了多种中间体作为新化合物，这些中间体对合成上述新的2'-氟可酶霉素衍生物是有用的。
• Novel bisphosphonates and uses thereof
  申请人：——

  公开号：US20020002140A1

  公开（公告）日：2002-01-03

  Glycosides and orthoester glyco side derivatives of bisphosphonate compounds useful for treating and/or preventing hypercalcaemia of malignancy, Paget's disease, osteoporosis, metastatic cancer in bone and soft tissue and periodontal disease have markedly enhanced intestinal absorption and enhanced bioavailability.

  糖苷和正酯基糖苷衍生物的双磷酸盐化合物可用于治疗和/或预防恶性高钙血症、佩吉特病、骨质疏松症、骨骼和软组织的转移性癌症以及牙周病，其具有明显增强的肠道吸收和生物利用度。