(1-Propyl-cyclopentyl)-methanol | 98954-95-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1-Propyl-cyclopentyl)-methanol
• 英文别名: (1-Propylcyclopentyl)methanol
• CAS: 98954-95-1
• 化学式: C₉H₁₈O
• 分子量: 142.241
• InChiKey: FFBMOKAYEAYECD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1-Propyl-cyclopentyl)-methanol 在 2,6-二甲基吡啶 、 草酰氯 、 偶氮二异丁腈 、 三正丁基氢锡 、 magnesium 、 二甲基亚砜 、 三乙胺 、 mercury dichloride 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 5.01h， 生成 (E)-1-iodo-4-(tert-butyldimethylsiloxy)-5,5-tetramethylene-1-octene
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8
• 作为产物：
  描述：

  环戊酸 在 lithium aluminium tetrahydride 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 15.5h， 生成 (1-Propyl-cyclopentyl)-methanol
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8

文献信息

• Preparation of Sunstituted 4-Pentenals
  作者：Kent C. Brannock

  DOI：10.1021/ja01522a057

  日期：1959.7
• [EN] PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS<br/>[FR] PYRAZOLOPYRIMIDINES ET HÉTÉROCYCLES ASSOCIÉS COMME INHIBITEURS DE CK2
  申请人：CYLENE PHARMACEUTICALS INC

  公开号：WO2012170827A2

  公开（公告）日：2012-12-13

  The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula:
• Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives
  作者：Kousuke Tani、Atsushi Naganawa、Akiharu Ishida、Kenji Sagawa、Hiroyuki Harada、Mikio Ogawa、Takayuki Maruyama、Shuichi Ohuchida、Hisao Nakai、Kigen Kondo、Masaaki Toda

  DOI：10.1016/s0968-0896(01)00369-8

  日期：2002.4

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.