2-萘基-Α-L-岩藻糖 | 63503-05-9

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-萘基-Α-L-岩藻糖
• 中文别名: 2-萘基-Alpha-L-岩藻糖
• 英文名称: Naphthyl-alpha-L-fucoside
• 英文别名: (2S,3S,4R,5S,6S)-2-methyl-6-naphthalen-2-yloxyoxane-3,4,5-triol
• CAS: 63503-05-9
• 化学式: C₁₆H₁₈O₅
• 分子量: 290.31
• InChiKey: HFJUQSUBZOKELZ-FITDYDNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NOVEL STRAIN HAVING PROPHYLACTIC OR THERAPEUTIC EFFECT ON CANCER
  申请人：Genome and Company

  公开号：EP3792343A1

  公开（公告）日：2021-03-17

  The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention has effects of inhibiting the proliferation of cancer cells, decreasing the mobility of cancer cells, inhibiting the neoangiogenesis, and increasing the anticancer immune response as well as reducing the expression of inflammatory factors, thereby having effects of preventing or treating cancers or inflammatory diseases. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. In addition, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect.

  本发明涉及一种新型双歧杆菌 MG731 菌株和一种预防或治疗癌症的组合物。具体来说，本发明的双歧杆菌 MG731 菌株具有抑制癌细胞增殖、降低癌细胞流动性、抑制新血管生成、增加抗癌免疫反应以及减少炎症因子表达的作用，从而具有预防或治疗癌症或炎症性疾病的效果。此外，本发明的双歧杆菌 MG731 菌株与抗癌化疗药物或抗癌免疫治疗药物联合使用时，抗癌效果更好。此外，本发明还涉及一种新型乳球菌 GEN3033 菌株和一种预防或治疗癌症的组合物。具体而言，本发明的乳球菌 GEN3033 菌株具有直接抑制癌细胞增殖和增强免疫力的作用，从而具有预防或治疗癌症的效果。特别是，该菌株在肠道中生长时，通过分泌具有抗癌作用的代谢物，具有极佳的抗癌效果。此外，当与抗癌化疗剂或抗癌免疫治疗剂联合使用时，本发明的乳球菌 GEN3033 菌株表现出更好的抗癌效果。
• Biological indicator
  申请人：American Sterilizer Company

  公开号：US10011843B2

  公开（公告）日：2018-07-03

  This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

  本发明涉及一种生物指示剂，其成分包括：由形成孢子的细菌组成的宿主生物；产生指示剂酶的报告基因；调控基因；以及将报告基因和调控基因插入宿主生物的载体；宿主生物的基因组中含有转座遗传因子，用于在调控基因中插入插入序列；插入序列包括转座酶、一对末端倒置重复序列和至少一个用于表达转座酶的开放阅读框。载体可被宿主生物吸收。插入序列可插入调控基因中。宿主生物可进行孢子繁殖以形成生物指示剂。本发明公开了一种使用生物指示剂的工艺和装置。
• Method for detecting Escherichia coli in a sample
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10023898B2

  公开（公告）日：2018-07-17

  A method of detecting Listeria monocytogenes. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system. The selective culture medium facilitates the growth of Listeria microorganisms. When a Listeria microorganism is detected in a sample contacted with the culture medium, the detection article is contacted with the culture medium to detect Listeria monocytogenes.

  一种检测李斯特菌的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。选择性培养基有利于李斯特菌微生物的生长。当在与培养基接触的样品中检测到李斯特菌微生物时，检测物品与培养基接触以检测单增李斯特菌。
• Method for detecting a Shigella or Cronobacter microorganism
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10619181B2

  公开（公告）日：2020-04-14

  A method of detecting a Shigella or Cronobacter microorganism. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system.

  一种检测志贺氏菌或克罗诺斯菌微生物的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。
• Rapid read-out biological indicator
  申请人：Minnesota Mining and Manufacturing Company to 3M Innovative Properties Company

  公开号：US20030077688A1

  公开（公告）日：2003-04-24

  A rapid method of determining the efficacy of a sterilization cycle, and an indicator adapted to perform such method, comprising subjecting to the sterilization cycle a source of active enzyme having activity which correlates with the viability of a microorganism commonly used to monitor sterilization, and incubating the enzyme source, following the completion of the sterilization cycle, with an effective amount of a substrate system capable of reacting with any residual active enzyme to produce a detectable enzyme-modified product.

  一种快速确定灭菌周期功效的方法，以及一种适用于执行该方法的指示剂，包括将活性酶源置于灭菌周期中，该酶源的活性与通常用于监测灭菌的微生物的活力相关；在灭菌周期完成后，将酶源与有效量的底物系统孵育，该底物系统能够与任何残留的活性酶发生反应，产生可检测的酶修饰产物。