(3,3-diphenyl-propyl)-methyl-amine; hydrochloride | 29768-15-8

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,3-diphenyl-propyl)-methyl-amine; hydrochloride
• 英文别名: (3,3-Diphenyl-propyl)-methyl-amin; Hydrochlorid；N-(methyl)-3,3-diphenylpropylamine hydrochloride；N-methyl-3,3-diphenyl-propylamine hydrochloride；N-methyl-3,3-diphenylpropylamine hydrochloride；N-methyl-3,3-diphenylpropan-1-amine;hydrochloride
• CAS: 29768-15-8
• 化学式: C₁₆H₁₉N*ClH
• 分子量: 261.794
• InChiKey: ZRSBFNZFGANOFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319

反应信息

• 作为反应物：
  描述：

  (3,3-diphenyl-propyl)-methyl-amine; hydrochloride 在 sodium tetrahydroborate 、 乙酸酐 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 5-O-[3-[3,3-diphenylpropyl(methyl)amino]-2,2-dimethylpropyl] 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  参考文献：
  名称：

  Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity

  摘要：

  A series of asymmetric 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates characterized by the presence of a 3,3-diphenyl-propylamino moiety in one of the ester groups were synthesized. They exhibited remarkable antihypertensive activity in spontaneously hypertensive rats as well as affinity for the 1,4-dihydropyridines binding site labelled by H-3-nitrendipine in the calcium channel. Introduction of this bulky and lipophilic amine confers to the whole series an elevated level of antihypertensive activity and a long duration of action, a structure-dependent modulation of the activity being found only in the subset characterized by the presence of a branched propylene bridge between the ester and the amino groups. The presence of the amino group is essential for oral activity. Out of this series, compound 9u (Rec 15/2375-lercanidipine) was selected for clinical development and obtained marketing authorization as an antihypertensive in several countries. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80015-9
• 作为产物：
  描述：

  3-(benzyl-methyl-amino)-1,1-diphenyl-propan-1-ol 在 PPA 作用下， 生成 (3,3-diphenyl-propyl)-methyl-amine; hydrochloride
  参考文献：
  名称：

  DE925468

  摘要：

  公开号：

文献信息

• Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing
  申请人：Alfa Farmaceutici, S.p.A.

  公开号：US04246201A1

  公开（公告）日：1981-01-20

  Compound of formula: ##STR1## wherein R represents hydrogen or an alkyl group having from 1 to 4 carbon atoms; R', R", R'" and R"", equal or different from each other represent hydrogen atoms or OH groups, with the limitation that when R', R", R'" and R"" are all hydrogen atoms R cannot be an hydrogen atom and their salts with organic and inorganic pharmaceutically acceptable salts. The process for the preparation of the compounds of the above general formula are disclosed. The compounds show a good pharmacological activity and can be used as antiulcer, antispastic spasmolytic drugs. The compounds can be administered as different pharmaceutical preparations containing an effective dose of the compound in combination or in admixture with excipients suitable for oral or parenteral administration or for topical use.

  化合物的化学式为：##STR1## 其中R代表氢或碳原子数为1至4的烷基基团；R'，R"，R'"和R""相等或不同，分别代表氢原子或羟基，但当R'，R"，R'"和R""均为氢原子时，R不能为氢原子，且它们与有机和无机药用可接受的盐的盐。公式所述化合物的制备方法已经公开。这些化合物具有良好的药理活性，可用作抗溃疡，抗痉挛药物。这些化合物可以作为不同的药物制剂，含有化合物的有效剂量，与适用于口服或注射或局部使用的赋形剂混合或组合使用。
• Process for polycyclic amines
  申请人：Aktiebolaget Leo

  公开号：US04249003A1

  公开（公告）日：1981-02-03

  This invention relates to a new method for the preparation of amines containing alkylene groups by using cyclic alkylene sulphuric esters, and novel intermediates for use in the method. The new method is useful for preparation of i.a. pharmaceuticals. The novel intermediates are useful i.a. as surfactants.

  本发明涉及一种使用环状烷基磺酸酯制备含有烷基的胺类化合物的新方法，以及用于该方法的新型中间体。该新方法对制备药物等具有实用价值，而新型中间体则对制备表面活性剂等具有实用价值。
• 一种合成乐卡地平中间体N-甲基-3，3-二苯基丙胺盐酸盐的方法
  申请人：大连万福制药有限公司

  公开号：CN115677512A

  公开（公告）日：2023-02-03

  一种合成乐卡地平中间体N‑甲基‑3，3‑二丙基苯胺的方法，其属于医药中间体合成的技术领域。在傅克烷基化反应时我们通过引用微流体技术负载Re2O7催化剂，以达到代替传统用三氯化铝催化反应的条件，优化了反应方案，使得反应的产率大幅度提高，同时降低了反应的危险性，反应催化剂循环使用也不会使生产成本提高。因为反应转化率的提高，所以不需要每步中间体的分离纯化，只需控制加料顺序就可以在一起直接反应。改善了反应中产生的污染物，减少了对环境的污染。优化后的反应方案，产率得到提高，成本降低，环境友好，符合绿色现代化生产要求。
• USE OF(S)-ENANTIOMERS OF 1,4-DIHYDROPYRIDINE DERIVATIVES FOR TREATING HEART FAILURE
  申请人：RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY

  公开号：EP0825862A1

  公开（公告）日：1998-03-04
• INTERMEDIATES FOR THE PREPARATION OF LERCANIDIPINE
  申请人：Motivan Ltd.

  公开号：EP1824824A1

  公开（公告）日：2007-08-29