2Α,6Β,23-三羟基齐墩果酸 | 564-13-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 2Α,6Β,23-三羟基齐墩果酸
• 英文名称: terminolic acid
• 英文别名: (4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• CAS: 564-13-6
• 化学式: C₃₀H₄₈O₆
• 分子量: 504.708
• InChiKey: IDQVFXZQPGAVAM-GGVBUJAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2Α,6Β,23-三羟基齐墩果酸 在 氢溴酸 、 溶剂黄146 作用下， 生成 2α,3β,13,23-tetrahydroxy-18α-olean-5-en-28-oic acid-13-lactone
  参考文献：
  名称：

  860.硬木提取物的化学成分。第二十七部分。末端酸的结构

  摘要：

  DOI：

  10.1039/jr9560004469
• 作为产物：
  描述：

  chebuloside II 在 氢氧化钾 作用下， 反应 3.0h， 生成 2Α,6Β,23-三羟基齐墩果酸
  参考文献：
  名称：

  Triterpenoids and their glycosides from Terminalia chebula

  摘要：

  Two new triterpenoid glycosides, chebuloside I and II were isolated from the stem bark of Terminalia chebula and shown to be beta-D-galactopyranosyl 2alpha,3beta,23-trihydroxyolean-12-en-28-oate and beta-D-glucopyranosyl 2alpha,3beta,6beta,23-tetrahydroxyolean-12-en-28-oate, respectively, based on their spectral data and some chemical transformations.

  DOI：

  10.1016/0031-9422(93)85243-k

文献信息

• Triterpene acids from some Papua New Guinea Terminalia species
  作者：David J. Collins、Carmel A. Pilotti、Adrian F.A. Wallis

  DOI：10.1016/0031-9422(92)80031-9

  日期：1992.3

  Abstract The trihydroxylated triterpene acids arjunolic acid and asiatic acid were found in ether extracts of the woods of Terminalia brassii and of T. complanata. Asiatic acid has not previously been reported as a constituent of the genus Terminalia. A similar extract of T. impediens yielded the tetrahydroxy acid terminolic acid as the major constituent; this acid was also detected as a minor constituent

  摘要 三羟基化的三萜酸阿周酚酸和积雪草酸存在于榄仁树和T. complanata 木材的醚提取物中。积雪草酸以前没有被报道为榄仁树属的成分。T. impediens 的类似提取物产生了作为主要成分的四羟基酸terminolic acid；这种酸也被检测为 T. complanata 的次要成分。然而，正如最近报道的那样，Terminolic acid 在积雪草的糖苷组合中不存在。
• Method for preparing a centella asiatica extract rich in madecassoside and in terminoloside
  申请人：Loiseau Alain

  公开号：US20060106206A1

  公开（公告）日：2006-05-18

  The invention concerns a method for preparing an extract comprising a mixture of madecassoside, terminoloside and optionally asiaticoside, an extract of Centella asiatica comprising more than 75 wt % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract of Centella asiatica comprising more than 95 wt. % of a mixture of madecassoside and terminoloside relative to the extract total weight and their use for regulating inflammatory mechanisms.

  该发明涉及一种制备提取物的方法，包括一个混合物，其中包括积雪草苷、终端苷和可选的积雪草苷，一种积雪草提取物，其中包括相对于提取物的总重量超过75重量％的积雪草苷、终端苷和积雪草苷的混合物，一种积雪草提取物，其中包括相对于提取物的总重量超过95重量％的积雪草苷和终端苷的混合物，并且它们用于调节炎症机制。
• METHOD FOR PREPARING A CENTELLA ASIATICA EXTRACT RICH IN MADECASSOSIDE AND IN TERMINOLOSIDE
  申请人：Loiseau Alain

  公开号：US20120178706A1

  公开（公告）日：2012-07-12

  The invention concerns an extract of Centella asiatica comprising more than 75 wt. % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract of Centella asiatica comprising more than 95 wt. % of a mixture of madecassoside and terminoloside relative to the extract total weight and their use for regulating inflammatory mechanisms.

  本发明涉及一种以积雪草提取物为基础的混合物，其包含相对于提取物总重量超过75重量％的积雪草苷、终端苷和穿心莲苷的混合物，以及相对于提取物总重量超过95重量％的积雪草苷和终端苷的混合物，并且它们用于调节炎症机制。
• ACCELERATOR FOR INITIAL INSULIN SECRETION
  申请人：Use-Techno Corporation

  公开号：EP1674089A1

  公开（公告）日：2006-06-28

  The present invention provides an early insulin secretion stimulator consisting of a triterpene represented by the following general formula (1) and/or a triterpene represented by the following general formula (2). [where R1 represents COOH, etc., R11 and R12 represent CH2OH, etc., X1 represents hydrogen or OH and X11, X12, X21 and X22 represent OH, etc.]

  本发明提供了一种早期胰岛素分泌刺激剂，由以下通式（1）代表的三萜和/或以下通式（2）代表的三萜组成。 [其中 R1 代表 COOH 等，R11 和 R12 代表 CH2OH 等，X1 代表氢或 OH，X11、X12、X21 和 X22 代表 OH 等。］
• King et al., Journal of the Chemical Society, 1955, p. 1338,1340
  作者：King et al.

  DOI：——

  日期：——