(R)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropan-1-ol | 60856-64-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropan-1-ol
• 英文别名: 2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-methylpropan-1-ol
• CAS: 60856-64-6
• 化学式: C₉H₁₈O₃
• 分子量: 174.24
• InChiKey: URTBPPCZPJXWTK-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropan-1-ol 在 titanium(IV) isopropylate 叔丁基过氧化氢 、 (-)-diethyl tartrate 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Total synthesis of elfamycins: aurodox and efrotomycin. 1. Strategy and construction of key intermediates

  摘要：

  DOI：

  10.1021/ja00292a038
• 作为产物：
  描述：

  3R-(-)-dihydro-4,4-dimethyl-3-<(methoxymethyl)oxy>-2(3H)-furanone 在 lithium aluminium tetrahydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 36.0h， 生成 (R)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropan-1-ol
  参考文献：
  名称：

  Chiral synthetic block based on (R)-pantolactone

  摘要：

  DOI：

  10.1070/mc2003v013n03abeh001755

文献信息

• [EN] TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS<br/>[FR] COMPOSÉS TRIAZOLOPYRIDINE COMME INHIBITEURS DE LA PIM KINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2010022076A1

  公开（公告）日：2010-02-25

  Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

  公式（I）的化合物，其中A、B、R1、R1a、R2、R3、R4、R5、R6和R7的含义如规范中所述，是在治疗免疫细胞相关疾病和紊乱方面有用的受体酪氨酸激酶抑制剂，例如炎症性和自身免疫疾病。
• TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS
  申请人：Allen Shelley

  公开号：US20110144085A1

  公开（公告）日：2011-06-16

  Compounds of Formula (I), in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

  公式（I）的化合物，其中A、B、R1、R1a、R2、R3、R4、R5、R6和R7的含义如规范中所述，是受体酪氨酸激酶抑制剂，适用于治疗与免疫细胞相关的疾病和障碍，如炎症和自身免疫性疾病。
• Triazolopyridine compounds as PIM kinase inhibitors
  申请人：Allen Shelley

  公开号：US08575145B2

  公开（公告）日：2013-11-05

  Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

  公式(I)的化合物，其中A、B、R1、R1a、R2、R3、R4、R5、R6和R7的含义如规范中给出的那样，是受体酪氨酸激酶抑制剂，用于治疗与免疫细胞相关的疾病和障碍，如炎症和自身免疫性疾病。
• Chemoselective Catalytic Oxidation of 1,2-Diols to α-Hydroxy Acids Controlled by TEMPO–ClO₂ Charge-Transfer Complex
  作者：Keisuke Furukawa、Masatoshi Shibuya、Yoshihiko Yamamoto

  DOI：10.1021/acs.orglett.5b01003

  日期：2015.5.1

  Chemoselective catalytic oxidation from 1,2-diols to a-hydroxy acids in a cat. TEMPO/cat. NaOCl/NaClO2 system has been achieved. The use of a two-phase condition consisting of hydrophobic toluene and water suppresses the concomitant oxidative cleavage. A study of the mechanism suggests that the observed selectivity is derived from the precise solubility: control of diols and hydroxy acids as well as the active species Of TEMPO, Although the oxoammonium species TEMPO+Cl- is hydrophilic, the active species dissolves into the organic layer by the formation of the charge-transfer (CT) complex TEMPO-ClO2 under the reaction conditions.
• Bryostatins: The asymmetric synthesis of C1-C9 and C11-C16 fragments
  作者：J. De Brabander、K. Vanhessche、M. Vandewalle

  DOI：10.1016/0040-4039(91)85096-n

  日期：1991.6

  The fragments C1-C-9 19 and C-11-C-16 26 of the bryostatins are constructed in an enantioselective and highly diastereoselective fashion from respectively D-pantolactone (2) and L-erythrulose (3) as chiral templates.