3,8-二甲基-7-癸烯-1-基三氢二磷酸酯 | 37247-98-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3,8-二甲基-7-癸烯-1-基三氢二磷酸酯
• 英文名称: Dolichyl diphosphate
• 英文别名: [(6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraenyl] phosphono hydrogen phosphate
• CAS: 37247-98-6
• 化学式: C₂₅H₄₆O₇P₂
• 分子量: 520.6
• InChiKey: MXGLYEVGJRXBTP-QOLULZROSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• BETA-NICOTINATE ESTER NUCLEOTIDES AND PROCESS FOR PREPARING SAME
  申请人：Cornell University

  公开号：US20200031860A1

  公开（公告）日：2020-01-30

  The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.

  本发明提供了一个式子为（I）的化合物：其中R如本文所述。本发明还提供了一种制备该化合物的方法。
• [EN] SYNTHESES, ACTIVITIES, AND METHODS OF USE OF DIHYDRONICOTINAMIDE RIBOSIDE DERIVATIVES<br/>[FR] SYNTHÈSES, ACTIVITÉS ET PROCÉDÉS D'UTILISATION DE DÉRIVÉS DU DIHYDRONICOTINAMIDE RIBOSIDE
  申请人：UNIV CORNELL

  公开号：WO2017011788A1

  公开（公告）日：2017-01-19

  Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.

  本发明涉及一种化合物，其化学式为(I)，其中R1、R2、R3等定义如下。本发明还涉及一种增加哺乳动物细胞NAD+产量和改善线粒体细胞密度的方法，包括将该化合物或其盐施用于细胞。
• Compositions and methods for treatment of neoplastic disease
  申请人：——

  公开号：US20020177551A1

  公开（公告）日：2002-11-28

  The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides, nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are tumoricidal T cells and NKT cells devoid of inhitory receptors or inhibitory signaling motifs which are hyperresponsive to the the above compositions and lipid-based tumor associated antigens that can be administered for adoptive immunotherapy of cancer and infectious diseases.

  本发明涉及一种用于治疗宿主体内肿瘤或肿瘤性疾病的组合物和方法。该方法采用包含超抗原多肽、具有其他结构的核酸和优先结合于肿瘤细胞并能够诱导细胞凋亡的结构的共轭物。还提供了超抗原-糖脂共轭物和负载于抗原呈递细胞上的囊泡，以激活T细胞和NKT细胞。基于细胞的疫苗包括肿瘤细胞，这些肿瘤细胞被改造以表达超抗原和糖脂产物，当这些细胞被引入哺乳动物体内时，这些细胞能够引起有效的抗肿瘤免疫反应。这些组合物包括肿瘤细胞、肿瘤细胞和辅助细胞的杂交细胞，优选为树突状细胞。还提供了无抑制性受体或抑制性信号基序的肿瘤细胞杀伤T细胞和NKT细胞，这些细胞对上述组合物和基于脂质的肿瘤相关抗原具有高度反应性，可用于癌症和传染病的免疫治疗。
• NICOTYL RIBOSIDE COMPOSITIONS AND METHODS OF USE
  申请人：SAUVE Anthony Andrew

  公开号：US20120172584A1

  公开（公告）日：2012-07-05

  The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

  本发明涉及烟酰胺核苷酸和烟酰胺核苷酸衍生物的组成物及其使用方法。在某些实施例中，本发明涉及制备烟酰胺核苷酰的方法。在某些实施例中，本发明涉及含有烟酰胺核苷酰的药物组合物和营养补充剂。在进一步的实施例中，本发明涉及使用烟酰胺核苷酰和烟酰胺核苷酸衍生物的方法，促进细胞和组织内烟酰胺腺嘌呤二核苷酸（NAD +）水平的增加，以改善细胞和组织的存活。
• NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE
  申请人：Cornell University

  公开号：US20150072950A1

  公开（公告）日：2015-03-12

  The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

  本发明涉及烟酰胺核苷酸和烟酰胺核苷酸衍生物的组合物及其使用方法。在某些实施例中，本发明涉及制备烟酰胺核苷酰组的方法。在某些实施例中，本发明涉及含有烟酰胺核苷酰的药物组合物和营养补充剂。此外，在进一步的实施例中，本发明涉及使用烟酰胺核苷酸和烟酰胺核苷酸衍生物的方法，以促进细胞和组织内烟酰胺腺嘌呤二核苷酸（NAD +）水平的增加，从而改善细胞和组织的存活。