5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)-amino>ethyl>-1-methyl-1H-indole-7-carboxamide | 101544-37-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)-amino>ethyl>-1-methyl-1H-indole-7-carboxamide
• 英文别名: 5-[1-Hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]-1-methylindole-7-carboxamide
• CAS: 101544-37-0
• 化学式: C₂₂H₂₇N₃O₂
• 分子量: 365.475
• InChiKey: IIVGKARVLHONDS-UHFFFAOYSA-N

物化性质

• 沸点：
  623.3±55.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  80.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-乙酰基-5-(氯乙酰基)二氢吲哚 在 platinum(IV) oxide 、 palladium on activated charcoal 吡啶 、 盐酸 、 potassium cyanide 、 manganese(IV) oxide 、 sodium hydroxide 、 sodium tetrahydroborate 、 tetrafluoroboric acid 、 氢气 、 双氧水 、 硝酸 、 sodium hydride 、 溶剂黄146 、 锌 、 sodium nitrite 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 溶剂黄146 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 29.58h， 生成 5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)-amino>ethyl>-1-methyl-1H-indole-7-carboxamide
  参考文献：
  名称：

  Indole-phenol-bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analog of labetalol

  摘要：

  The synthesis of 5-[hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-1H-indole-7- carboxamide, 5, a pyrrolo analogue of labetalol, is described. Compound 5 was found to reduce blood pressure in spontaneously hypertensive rats with an ED50 of 5 mg/kg po, without causing any decrease in heart rate. Isolated tissue studies with 5 shows that it is a nonselective beta-adrenoceptor antagonist and that it is a weaker alpha-adrenoceptor antagonist with a relative selectivity for alpha 1-receptors. Additionally, the compound displayed significant beta-adrenoceptor intrinsic sympathomimetic activity. Evidence is presented that the beta-adrenoceptor antagonist and agonist properties of 5 are mediated via hydrogen-bond formation with the receptor.

  DOI：

  10.1021/jm00156a019

文献信息

• Indole-phenol-bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analog of labetalol
  作者：Andre A. Asselin、Leslie G. Humber、Danilo Crosilla、George Oshiro、Alexandra Wojdan、David Grimes、Richard J. Heaslip、Thomas J. Rimele、Chia Cheng Shaw

  DOI：10.1021/jm00156a019

  日期：1986.6

  The synthesis of 5-[hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-1H-indole-7- carboxamide, 5, a pyrrolo analogue of labetalol, is described. Compound 5 was found to reduce blood pressure in spontaneously hypertensive rats with an ED50 of 5 mg/kg po, without causing any decrease in heart rate. Isolated tissue studies with 5 shows that it is a nonselective beta-adrenoceptor antagonist and that it is a weaker alpha-adrenoceptor antagonist with a relative selectivity for alpha 1-receptors. Additionally, the compound displayed significant beta-adrenoceptor intrinsic sympathomimetic activity. Evidence is presented that the beta-adrenoceptor antagonist and agonist properties of 5 are mediated via hydrogen-bond formation with the receptor.