5-(4-aminosulfonylphenyl)-(4-fluorophenyl)-3-pivaloylmethoxy-pyrazole | 329076-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-aminosulfonylphenyl)-(4-fluorophenyl)-3-pivaloylmethoxy-pyrazole
• 英文别名: 5-(4-(aminosulphonyl)phenyl)-4-(4-fluorophenyl)-3-trimethylacetyl-methoxypyrazole；5-(4-Aminosulphonylphenyl)-4-(4-fluorophenyl)-3-trimethylacetylmethoxypyrazole；4-[3-(3,3-dimethyl-2-oxobutoxy)-4-(4-fluorophenyl)-1H-pyrazol-5-yl]benzenesulfonamide
• CAS: 329076-82-6
• 化学式: C₂₁H₂₂FN₃O₄S
• 分子量: 431.488
• InChiKey: FCVAUXWURIECQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(4-aminosulfonylphenyl)-(4-fluorophenyl)-3-pivaloylmethoxy-pyrazole 在 对甲苯磺酸 作用下， 以 水 、 溶剂黄146 、 甲苯 为溶剂， 反应 4.0h， 以80%的产率得到3-(Tert-butyl)-7-(4-fluorophenyl)-6-(4-(aminosulphonyl)phenyl)pyrazolo[5,1-b][1,3]-oxazole
  参考文献：
  名称：

  SULFONYLPHENYLPYRAZOLE COMPOUNDS USEFUL AS COX-2 INHIBITORS

  摘要：

  公开号：

  EP1206474B1
• 作为产物：
  描述：

  对羧基苯磺酰胺 在 草酰氯 、 potassium carbonate 、 一水合肼 、 溶剂黄146 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.83h， 生成 5-(4-aminosulfonylphenyl)-(4-fluorophenyl)-3-pivaloylmethoxy-pyrazole
  参考文献：
  名称：

  Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors

  摘要：

  4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolo-oxazines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2 inhibitors. Compounds 11b,c were successfully synthesized with use of pyridinium p-toluenesulfonate mediated cyclization of the ketal intermediate. Diaryl-pyrazolo-benzooxazepine analogues were synthesized by using Cu-mediated cyclization of the O-alkylated arylbromide intermediate. Arylsulfonamides were synthesized efficiently on a large scale with 4-[4-(4-fluorophenyl)-5-hydroxy-2H-pyrazol-3-yl]benzenesulfonamide 31 template readily synthesized from commercially available 4-sulfamoyl benzoic acid 29. The structure of a representative compound from each class was confirmed by X-ray crystallography. Selected compounds tested for inhibitory activity against COX-1 and COX-2 enzymes showed good selectivity for COX-2 versus COX-1 enzyme.

  DOI：

  10.1021/jo049264k

文献信息

• SULFONYLPHENYLPYRAZOLE COMPOUNDS USEFUL AS COX-2 INHIBITORS
  申请人：ABBOTT LABORATORIES

  公开号：EP1206474B1

  公开（公告）日：2004-05-26
• US6472416B1
  申请人：——

  公开号：US6472416B1

  公开（公告）日：2002-10-29
• [EN] SULFONYLPHENYLPYRAZOLE COMPOUNDS USEFUL AS COX-2 INHIBITORS<br/>[FR] COMPOSES SULFONYLPHENYLPYRAZOLES UTILES EN TANT QU'INHIBITEURS DE COX-2
  申请人：ABBOTT LAB

  公开号：WO2001016138A1

  公开（公告）日：2001-03-08

  The present invention encompasses novel sulfonylphenylpyrazole compounds useful in the treatment of cyclooxygenase-2 mediated diseases.
• Synthesis of 4,5-Diaryl-1<i>H</i>-pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors
  作者：Meena V. Patel、Randy Bell、Sandra Majest、Rodger Henry、Teodozyj Kolasa

  DOI：10.1021/jo049264k

  日期：2004.10.1

  4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolo-oxazines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2 inhibitors. Compounds 11b,c were successfully synthesized with use of pyridinium p-toluenesulfonate mediated cyclization of the ketal intermediate. Diaryl-pyrazolo-benzooxazepine analogues were synthesized by using Cu-mediated cyclization of the O-alkylated arylbromide intermediate. Arylsulfonamides were synthesized efficiently on a large scale with 4-[4-(4-fluorophenyl)-5-hydroxy-2H-pyrazol-3-yl]benzenesulfonamide 31 template readily synthesized from commercially available 4-sulfamoyl benzoic acid 29. The structure of a representative compound from each class was confirmed by X-ray crystallography. Selected compounds tested for inhibitory activity against COX-1 and COX-2 enzymes showed good selectivity for COX-2 versus COX-1 enzyme.