methyl (S)-3-(tert-butyldimethylsiloxy)-2-(methoxymethoxy)propionate | 518027-30-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (S)-3-(tert-butyldimethylsiloxy)-2-(methoxymethoxy)propionate
• 英文别名: methyl (2S)-3-[tert-butyl(dimethyl)silyl]oxy-2-(methoxymethoxy)propanoate
• CAS: 518027-30-0
• 化学式: C₁₂H₂₆O₅Si
• 分子量: 278.421
• InChiKey: VOIATFLUBUNEDC-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.17
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl (S)-3-(tert-butyldimethylsiloxy)-2-(methoxymethoxy)propionate 在 重铬酸吡啶 、 正丁基锂 、 四丁基氟化铵 、 二异丁基氢化铝 、 1-羟基苯并三唑 、 对甲苯磺酸 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 5.17h， 生成 (2S,3R,2'R,3'Z)-2-N-(2'-methoxymethoxy-3'-octadecenoyl)-[2-amino-octadecan-1,3-diol]
  参考文献：
  名称：

  Total Syntheses of Symbioramide Derivatives from l-Serine and Their Antileukemic Activities

  摘要：

  Naturally occurring symbioramide, (2S,3R,2'R,3'E)-N-(2'-hydroxy-3'-octadecenoyl)-dihydrosphingosine la, was synthesized from D-erythro-dihydrosphingosine (amino part, 2) and (2R,3E)-2-hydroxy-3-octadecenoic acid (acid part, 3a), both of which were prepared from L-serine. Its diastereomer, (2S,3R,2'S,3'E)-1b, having an enantiomer of the unnatural-type acid part that was prepared from D-mannitol, and its corresponding (Z)-isomers, (2S,3R,2R,3'Z)-1c and (2S,3R,2'S,3'Z)-1d, were also prepared. The antileukemic activities of 1a-d against HL-60 and L-1210 cells were appreciated by a MTT assay. None of the four symbioramide derivatives showed antileukemic activities in HL-60 cells. In L-1210 cells, all the symbioramide derivatives showed moderate antileukemic activities. Compound 1d had the most effective activity against L-1210 cells among the four derivatives. The data suggest that unnatural types of (2'S)-isomers of acid parts are more active than those of (2R)-isomers.

  DOI：

  10.1021/jo0206824
• 作为产物：
  描述：

  氯甲基甲基醚 、 methyl (S)-3-O-(tert-butyldimethylsilyl)glycerate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以84%的产率得到methyl (S)-3-(tert-butyldimethylsiloxy)-2-(methoxymethoxy)propionate
  参考文献：
  名称：

  Total Syntheses of Symbioramide Derivatives from l-Serine and Their Antileukemic Activities

  摘要：

  Naturally occurring symbioramide, (2S,3R,2'R,3'E)-N-(2'-hydroxy-3'-octadecenoyl)-dihydrosphingosine la, was synthesized from D-erythro-dihydrosphingosine (amino part, 2) and (2R,3E)-2-hydroxy-3-octadecenoic acid (acid part, 3a), both of which were prepared from L-serine. Its diastereomer, (2S,3R,2'S,3'E)-1b, having an enantiomer of the unnatural-type acid part that was prepared from D-mannitol, and its corresponding (Z)-isomers, (2S,3R,2R,3'Z)-1c and (2S,3R,2'S,3'Z)-1d, were also prepared. The antileukemic activities of 1a-d against HL-60 and L-1210 cells were appreciated by a MTT assay. None of the four symbioramide derivatives showed antileukemic activities in HL-60 cells. In L-1210 cells, all the symbioramide derivatives showed moderate antileukemic activities. Compound 1d had the most effective activity against L-1210 cells among the four derivatives. The data suggest that unnatural types of (2'S)-isomers of acid parts are more active than those of (2R)-isomers.

  DOI：

  10.1021/jo0206824

文献信息

• Total Syntheses of Symbioramide Derivatives from <scp>l</scp>-Serine and Their Antileukemic Activities
  作者：Hideki Azuma、Ryoko Takao、Hayato Niiro、Keiji Shikata、Seizo Tamagaki、Taro Tachibana、Kenji Ogino

  DOI：10.1021/jo0206824

  日期：2003.4.1

  Naturally occurring symbioramide, (2S,3R,2'R,3'E)-N-(2'-hydroxy-3'-octadecenoyl)-dihydrosphingosine la, was synthesized from D-erythro-dihydrosphingosine (amino part, 2) and (2R,3E)-2-hydroxy-3-octadecenoic acid (acid part, 3a), both of which were prepared from L-serine. Its diastereomer, (2S,3R,2'S,3'E)-1b, having an enantiomer of the unnatural-type acid part that was prepared from D-mannitol, and its corresponding (Z)-isomers, (2S,3R,2R,3'Z)-1c and (2S,3R,2'S,3'Z)-1d, were also prepared. The antileukemic activities of 1a-d against HL-60 and L-1210 cells were appreciated by a MTT assay. None of the four symbioramide derivatives showed antileukemic activities in HL-60 cells. In L-1210 cells, all the symbioramide derivatives showed moderate antileukemic activities. Compound 1d had the most effective activity against L-1210 cells among the four derivatives. The data suggest that unnatural types of (2'S)-isomers of acid parts are more active than those of (2R)-isomers.