6β,7β-diacetoxy-13-hydroxy-labda-8,14-diene | 260792-29-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 6β,7β-diacetoxy-13-hydroxy-labda-8,14-diene
• 英文别名: (13R)-6β,7β-diacetoxy-labda-8,14-dien-13-ol；6I(2),7I(2)-Diacetoxy-13-hydroxylabda-8,14-diene；[(1S,2R,4aS,8aS)-2-acetyloxy-4-[(3R)-3-hydroxy-3-methylpent-4-enyl]-3,4a,8,8-tetramethyl-1,2,5,6,7,8a-hexahydronaphthalen-1-yl] acetate
• CAS: 260792-29-8
• 化学式: C₂₄H₃₈O₅
• 分子量: 406.563
• InChiKey: JVKGUKYXQMTNOK-DXSQJRSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (13R)-labda-8,14-diene-6β,7β,13-triol 、 乙酸酐 在 吡啶 作用下， 反应 144.0h， 以96%的产率得到6β,7β-diacetoxy-13-hydroxy-labda-8,14-diene
  参考文献：
  名称：

  Synthetic studies to highly functionalised B ring labdanes

  摘要：

  Several 6,7-dioxygenated (cis or trans) labdanes have been synthesised starting front sclareol. A new strategy that allows the obtention of diols alpha-cis as well as beta-cis of trans is described. In particular, the syntheses of three natural highly functionalised labdanes in the B rings of 2, 3 and 4 with different side chains are reported. The syntheses have permitted to Correct the proposed Structure for one of them. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.083

文献信息

• Synthetic studies to highly functionalised B ring labdanes
  作者：I.S. Marcos、L. Castañeda、P. Basabe、D. Díez、J.G. Urones

  DOI：10.1016/j.tet.2008.06.083

  日期：2008.9

  Several 6,7-dioxygenated (cis or trans) labdanes have been synthesised starting front sclareol. A new strategy that allows the obtention of diols alpha-cis as well as beta-cis of trans is described. In particular, the syntheses of three natural highly functionalised labdanes in the B rings of 2, 3 and 4 with different side chains are reported. The syntheses have permitted to Correct the proposed Structure for one of them. (C) 2008 Elsevier Ltd. All rights reserved.