(4,8-anhydro-2,3-di-O-benzyl-6,7-dideoxy-8S-C-phenyl-β-D-manno-octopyranosyl)-(1→3)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose | 1421832-86-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4,8-anhydro-2,3-di-O-benzyl-6,7-dideoxy-8S-C-phenyl-β-D-manno-octopyranosyl)-(1→3)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose
• 英文别名: (2S,3S,4S,4aR,6S,8aR)-2-[[(3aR,5R,6S,6aR)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl]oxy]-6-phenyl-3,4-bis(phenylmethoxy)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran
• CAS: 1421832-86-1
• 化学式: C₄₀H₄₈O₁₀
• 分子量: 688.815
• InChiKey: MPNBMGQQLZHVAT-TVILBIMKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  50
• 可旋转键数：
  10
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  92.3
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  S-phenyl 2,3-di-O-benzyl-α-D-thiomannopyranoside 在 吡啶 、 甲醇 、 4-二甲氨基吡啶 、 Stryker's reagent 、 1-(苯基亚硫酰基)哌啶 、 水 、 sodium methylate 、 戴斯-马丁氧化剂 、 三氟乙酸 、 三氟乙酸酐 、 2,4,6-三叔丁基嘧啶 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 苯 为溶剂， 反应 267.5h， 生成 (4,8-anhydro-2,3-di-O-benzyl-6,7-dideoxy-8S-C-phenyl-α-D-manno-octopyranosyl)-(1→3)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 、 (4,8-anhydro-2,3-di-O-benzyl-6,7-dideoxy-8S-C-phenyl-β-D-manno-octopyranosyl)-(1→3)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose
  参考文献：
  名称：

  Influence of O6 in Mannosylations Using Benzylidene Protected Donors: Stereoelectronic or Conformational Effects?

  摘要：

  The stereoselective synthesis of beta-mannosides and the underlying reaction mechanism have been thoroughly studied, and especially the benzylidene-protected mannosides have gained a lot of attention since the corresponding mannosyl triflates often give excellent selectivity. The hypothesis for the enhanced stereoselectivity has been that the benzylidene locks the molecule in a less reactive conformation with the O6 trans to the ring oxygen (O5), which would stabilize the formed alpha-triflate and subsequent give beta-selectivity. In this work, the hypothesis is challenged by using the carbon analogue (C7) of the benzylidene-protected mannosyl donor, which is investigated in terms of diastereoselectivity and reactivity and by low-temperature NMR In terms of diastereoselectivity, the C-7-analogue behaves similarly to the benzylidene-protected donor, but its low-temperature NMR reveals the formation of several reactive intermediate. One of the intermediates was found to be the beta-oxosulfonium ion. The reactivity of the donor was found to be in between that of the "torsional" disarmed and an armed donor.

  DOI：

  10.1021/jo302455d