(R)-(+)-4-(1,5-dimethyl-1-vinyl-4-hexenyl)-3-cyclohexenone | 917892-89-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (R)-(+)-4-(1,5-dimethyl-1-vinyl-4-hexenyl)-3-cyclohexenone
• 英文别名: 4-[(3R)-3,7-Dimethylocta-1,6-dien-3-yl]cyclohex-3-en-1-one；4-[(3R)-3,7-dimethylocta-1,6-dien-3-yl]cyclohex-3-en-1-one
• CAS: 917892-89-8
• 化学式: C₁₆H₂₄O
• 分子量: 232.366
• InChiKey: VIHPQEWTKZTYKH-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-(+)-4-(1,5-dimethyl-1-vinyl-4-hexenyl)-3-cyclohexenone 在 sodium carbonate 、 palladium dichloride 作用下， 以 叔丁醇 为溶剂， 反应 6.0h， 以74%的产率得到(R)-(-)-4-(1,5-dimethyl-1-vinyl-4-hexenyl)phenol
  参考文献：
  名称：

  A short and efficient synthesis of (R)-(−)-sporochnol A

  摘要：

  A short and efficient synthesis of (R)-(-)-sporochnol A in five steps and 9% overall yield has been developed. The sequence uses as starting material the easily available enantiopure monoketal derived from 1,4-cyclohexanedione and (R,R)-hydrobenzoin that serves as a chiral auxiliary. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.09.013
• 作为产物：
  描述：

  (2R,3R,1'R)-(+)-8-(1,5-dimethyl-1-vinyl-4-hexenyl)-2,3-diphenyl-1,4-dioxaspiro[4.5]decan-8-ol 在 吡啶 、 氯化亚砜 、 montmorillonite K-10 、 水 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 7.25h， 生成 (R)-(+)-4-(1,5-dimethyl-1-vinyl-4-hexenyl)-3-cyclohexenone
  参考文献：
  名称：

  A short and efficient synthesis of (R)-(−)-sporochnol A

  摘要：

  A short and efficient synthesis of (R)-(-)-sporochnol A in five steps and 9% overall yield has been developed. The sequence uses as starting material the easily available enantiopure monoketal derived from 1,4-cyclohexanedione and (R,R)-hydrobenzoin that serves as a chiral auxiliary. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.09.013

文献信息

• A short and efficient synthesis of (R)-(−)-sporochnol A
  作者：Ramón Alibés、Félix Busqué、Gisela G. Bardají、Pedro de March、Marta Figueredo、Josep Font

  DOI：10.1016/j.tetasy.2006.09.013

  日期：2006.10

  A short and efficient synthesis of (R)-(-)-sporochnol A in five steps and 9% overall yield has been developed. The sequence uses as starting material the easily available enantiopure monoketal derived from 1,4-cyclohexanedione and (R,R)-hydrobenzoin that serves as a chiral auxiliary. (c) 2006 Elsevier Ltd. All rights reserved.