3-氧代环戊烷甲腈 | 41171-91-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-氧代环戊烷甲腈
• 英文名称: 3-oxocyclopentane-1-carbonitrile
• 英文别名: 3-oxocyclopentanecarbonitrile；3-cyanocyclopentanone
• CAS: 41171-91-9
• 化学式: C₆H₇NO
• mdl: MFCD21184612
• 分子量: 109.128
• InChiKey: RJDDBRGASHENKL-UHFFFAOYSA-N

物化性质

• 沸点：
  250-270 °C(Press: 1 Torr)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  3-氧代环戊烷甲腈 在 copper(l) iodide 、 水 、 草酸 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 、 甲苯 、 苯 为溶剂， 反应 63.5h， 生成 trans-5,6-diphenylbicyclo<3.1.0>hexan-2-one
  参考文献：
  名称：

  General Theoretical Treatments of Solid-State Photochemical Rearrangements and a Variety of Contrasting Crystal versus Solution Photochemistry

  摘要：

  In continuing our investigations of control of excited state reactivity by inclusion in crystal lattices, we have encountered a variety of new examples of differing reactivity resulting from lattice restraints. Different theoretical treatments were tested and several proved applicable. Not only could the course of reactions imposed by the crystal lattice be predicted but also the ability to react versus lack of reactivity. For cyclohexenones with C-2 and C-5 substitution, either of two aryl groups at C-4 are available for migration; which one migrates depends on the lattice. One C-2 substituted and seven C-5 substituted cyclohexenones were investigated. Additionally some cyclopentenone photochemistry was investigated. Throughout, programming was developed to generate a ''mini crystal lattice'' having the appropriate space group symmetry and X-ray coordinates and with a central molecule surrounded by reactant molecules. Replacement of the central molecule with a transition state molecule provided a new ''mini-lattice''. Generally, the first diradical intermediate was used to simulate the reaction transition state. The mini-lattice was then subject to study. Overlap of the central, partially reacted species with the surrounding molecules provided one criterion. Molecular motion of the reactant excited state in forming the partially reacted species provided a test of least motion as a second criterion. A third test utilizing MM3 geometry optimization of the reacting species imbedded in the rigid mini-lattice, provided a measure of the increase in intra- and intermolecular energy of this molecule. A final approach determined the points of nearest molecule-lattice approach and mapped these in the form of a ''lock and key''; this has the advantage of indicating which interactions result in inhibition or lack thereof of a particular reaction route. Predicting ability to react proved important since reactivity falls into three categories: (I) no reaction in the lattice, (2) differing reactivity compared to solution, (3) the same behavior in solution. Perturbing an intermediate geometry toward that of the reactant and then determining the deformation energy provided a reactivity measure.

  DOI：

  10.1021/ja00124a008
• 作为产物：
  描述：

  3-亚甲基环丁基甲腈 在 双(乙腈)氯化钯(II) 、 亚硝酸特丁酯 、 水 作用下， 以 乙醇 为溶剂， 以34 %的产率得到3-氧代环戊烷甲腈
  参考文献：
  名称：

  亚甲基环丁烷的瓦克氧化：异常环境中的范围和选择性

  摘要：

  亚甲基环丁烷在温和的反应条件下经过瓦克氧化生成环戊酮。提出半频哪醇型重排负责中间 1,2-转移，这不仅解释了产物的形成，而且还使反应结果在位点、区域和对映选择性方面合理化。

  DOI：

  10.1002/anie.202215381

文献信息

• [EN] HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS D'AMIDES HÉTÉROCYCLIQUES UTILISÉS COMME ANTAGONISTES DU RÉCEPTEUR P2X7
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2014115072A1

  公开（公告）日：2014-07-31

  The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, n, m, p and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  本发明涉及式(I)的杂环酰胺衍生物，其中R1、R2、R3、R4、R5、n、m、p和X如描述中定义，及其制备方法和作为药物活性化合物用途。
• PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF
  申请人：Incyte Corporation

  公开号：US20180072720A1

  公开（公告）日：2018-03-15

  Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

  揭示了化合物的公式（I），使用这些化合物抑制HPK1活性的方法以及包含这些化合物的药物组合物。这些化合物在治疗、预防或改善与HPK1活性相关的疾病或紊乱方面是有用的，如癌症。
• Facile synthesis of 2-azaspiro[3.4]octane
  作者：Subbiah Ramesh、Ramadas Balakumar、John R. Rizzo、Tony Y. Zhang

  DOI：10.1039/c9ob00306a

  日期：——

  Our annulation strategy utilized for the synthesis of 2-azaspiro[3.4]octane is explained. Three successful routes for the synthesis were developed. One of the approaches involved annulation of the cyclopentane ring and the remaining two approaches involved annulation of the four membered ring. All three approaches employ readily available starting materials with conventional chemical transformations

  说明了我们用于合成2-azaspiro [3.4]辛烷的环空策略。开发了三种成功的合成途径。一种方法涉及环戊烷环的环空，其余两种方法涉及四元环的环空。所有这三种方法均采用具有常规化学转化和最小限度的色谱纯化的容易获得的起始原料，以提供标题化合物。还讨论了这三种方法的优缺点。
• [EN] PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE<br/>[FR] DÉRIVÉS DE PYRROLO[2,3-D]PYRIMIDINE UTILES POUR INHIBER LA JANUS KINASE
  申请人：PFIZER

  公开号：WO2016024185A1

  公开（公告）日：2016-02-18

  Described herein are pyrrolo2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing them, and therapeutic uses thereof.

  本文描述了吡咯2,3-d}嘧啶衍生物，它们作为Janus激酶（JAK）抑制剂的用途，含有它们的药物组合物，以及它们的治疗用途。
• Samarium diiodide-mediated pinacolization of diketones—II. Synthesis of polycyclic frameworks containing a cyclobutane-1,2-diol and a cyclopentane-1,2-diol
  作者：Olaf Nowitzki、Ira Münnich、Holger Stucke、H.M.R. Hoffmann

  DOI：10.1016/0040-4020(96)00688-6

  日期：1996.9

  The title reaction has been applied to the synthesis of a variety of polycyclic networks. Scope and limitations of the procedure are evaluated.

  标题反应已应用于多种多环网络的合成。评估程序的范围和局限性。