4-Bromo-3-methyl-1H-pyrrole-2-carboxylic acid | 1092286-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-Bromo-3-methyl-1H-pyrrole-2-carboxylic acid
• CAS: 1092286-06-0
• 化学式: C₆H₆BrNO₂
• 分子量: 204.02
• InChiKey: LIKZINJLVUQUOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Pyrrolo[1,2-a]quinoxaline derivatives as Adenosine A3 receptor modulators and uses thereof
  申请人：Faust Pharmaceuticals

  公开号：EP1798233A1

  公开（公告）日：2007-06-20

  The present invention provides new compounds of formula (I) displaying high affinity for adenosine A3 receptors. It also provides modulators of adenosine A3 receptors. It further provides compounds for the treatment and/or prophylaxis of conditions and diseases where adenosine A3 receptor plays a role. Pharmaceutical compositions for the treatment and/or prophylaxis of conditions and diseases where adenosine A3 receptors play a role are also described.

  本发明提供了具有高亲和力的式（I）新化合物，用于腺苷A3受体。它还提供了腺苷A3受体的调节剂。此外，还提供了用于治疗和/或预防腺苷A3受体在疾病和病症中发挥作用的化合物。还描述了用于治疗和/或预防腺苷A3受体在疾病和病症中发挥作用的药物组合物。
• PYRROLO[1,2-A]QUINOXALINE DERIVATIVES AS ADENOSINE A3 RECEPTOR MODULATORS AND USES THEREOF
  申请人：Schann Stephan

  公开号：US20090093476A1

  公开（公告）日：2009-04-09

  The present invention provides new compounds displaying high affinity for adenosine A 3 receptors. It also provides modulators of adenosine A 3 receptors. It further provides compounds for the treatment and/or prophylaxis of conditions and diseases where adenosine A 3 receptor plays a role. Pharmaceutical compositions for the treatment and/or prophylaxis of conditions and diseases where adenosine A 3 receptors play a role are also described.

  本发明提供了一种新的化合物，具有高亲和力的腺苷A3受体。它还提供了腺苷A3受体的调节剂。此外，它还提供了用于治疗和/或预防腺苷A3受体在疾病和病症中发挥作用的化合物。还描述了用于治疗和/或预防腺苷A3受体在疾病和病症中发挥作用的药物组合物。
• PYRROLO Ýl,2-A¨QUINOXALINE DERIVATIVES AS ADENOSINE A3 RECEPTOR MODULATORS AND USES THEREOF
  申请人：Faust Pharmaceuticals

  公开号：EP1973916A1

  公开（公告）日：2008-10-01
• INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES
  申请人：North Carolina State University

  公开号：EP2053920A1

  公开（公告）日：2009-05-06
• INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES
  申请人：North Carolina State University

  公开号：EP2224809A1

  公开（公告）日：2010-09-08